Early NFL Week 13 Predictions and Picks Against the Spread: Picks Include Patrick Mahomes, C.J. Stroud, Tua Tagovailoa, and Others

The NFL betting lines for next week are up, so it's time to give our initial picks. Here are our early NFL Week 13 predictions and picks against the spread.

Of all the NFL Week 13 matchups, the most anticipated game will easily be the NFC Championship rematch between the San Francisco 49ers and the Philadelphia Eagles. When the NFL betting lines came out for next week, many people were surprised to see the Eagles as home underdogs. Will Philly continue to find ways to win, or will the 49ers get revenge for last season? Find out where I’m leaning in my early NFL Week 13 predictions and picks against the spread.

NFL Week 13 Predictions and Picks

All odds are from FanDuel Sportsbook.

Seattle Seahawks vs. Dallas Cowboys Odds

  • Spread
    Cowboys -9
  • Moneyline
    Seahawks +350, Cowboys -450
  • Total
    46.5

Taking the Cowboys here would feel like buying too high on them and selling too low on Seattle.

MORE: PFN’s FREE NFL Playoff Predictor

The Cowboys are clearly the better team, and they’ve dominated at home, but getting nearly 10 points seems like too much value to pass up with Seattle. Dallas’ dominance in recent weeks makes me nervous here though.

Pick: Seahawks +9.5

Los Angeles Chargers vs. New England Patriots Odds

  • Spread
    Chargers -6
  • Moneyline
    Chargers -255, Patriots +210
  • Total
    39.5

It would be peak Chargers to lose to the 2023 Patriots, but even the biggest Brandon Staley hater would be surprised by that. The Patriots have scored 13 points over their last two games — this feels like an easy under play no matter who is playing quarterback.

Pick: Under 39.5

Arizona Cardinals vs. Pittsburgh Steelers Odds

  • Spread
    Steelers -5.5
  • Moneyline
    Cardinals +210, Steelers -255
  • Total
    39.5

To the surprise of almost nobody, the Steelers’ offense had its best performance of the season on Sunday in its first game without Matt Canada calling plays.

After a comeback win in Kyler Murray’s 2023 debut, it appears the Cardinals have fallen back to reality, but is this too many points for the Steelers? It may be, but I’m going to wait it out before taking the Cardinals to get points.

Pick: Lean Cardinals +5.5

Denver Broncos vs. Houston Texans Odds

  • Spread
    Texans -3.5
  • Moneyline
    Broncos +152, Texans -180
  • Total
    46.5

This Broncos defense has been on a roll, but playing against C.J. Stroud on the road will be far more challenging than Dorian Thompson-Robinson at home. I like this as a bounce-back spot for the Texans next week, as I don’t think Russell Wilson and Company will be able to pick apart their defense like Trevor Lawrence and the Jacksonville Jaguars did on Sunday.

Pick: Texans -3.5

Detroit Lions vs. New Orleans Saints Odds

  • Spread
    Lions -4.5
  • Moneyline
    Lions -198, Saints +166
  • Total
    45.5

Both teams are coming off brutal losses to division rivals, but the Saints suffered a ton of injuries on Sunday. They also out-gained the Atlanta Falcons by 48 yards but were 0-5 in the red zone.

MORE: NFL Against the Spread Standings

The Saints are very banged up, especially on offense, which has me liking the Lions here in a bounce-back spot, especially with their rest advantage. If the Saints have positive injury news this week, I might be swayed.

Pick: Lean Lions -4.5

Indianapolis Colts vs. Tennessee Titans Odds

  • Spread
    Colts -2
  • Moneyline
    Colts -126, Titans +108
  • Total
    42.5

The Colts are a very surprising 6-5, but I’m not so sure if I’m ready to lay points with them as a road favorite, even at just 1.5. At the same time, it’s hard to hop on the Titans’ bandwagon because they beat the Panthers by one score at home. This is going to be a pass for me for the time being.

Atlanta Falcons vs. New York Jets Odds

  • Spread
    Falcons -2.5
  • Moneyline
    Falcons -146, Jets +124
  • Total
    34

Until the Jets show signs of life offensively, I’m going to have a difficult time wanting to put any money on them. Even if their defense has been performing up to expectations as of late, I don’t trust Desmond Ridder against them on the road. Considering I also don’t trust Tim Boyle and this Jets offense to put up points, I’ll take the under on a very low total here.

Pick: Under 34

Miami Dolphins vs. Washington Commanders Odds

  • Spread
    Dolphins -9.5
  • Moneyline
    Dolphins -480, Commanders +370
  • Total
    49.5

This Commanders defense now might be the worst in the NFL, although we could see them come out motivated following the firing of DC Jack Del Rio — or they’re just really bad.

Mike McDaniel should have his way with them, and I expect Tua Tagovailoa and Tyreek Hill to put up big numbers. This could be another Miami beatdown of a bad football team.

Pick: Dolphins -9.5

Carolina Panthers vs. Tampa Bay Buccaneers Odds

  • Spread
    Buccaneers -5.5
  • Moneyline
    Panthers +198, Buccaneers -240
  • Total
    37.5

Any team playing against the Panthers is going to be a bit overvalued, but they have still only covered one game this season, so I have no interest in wanting to back Carolina. This is going to be a really popular teaser spot or moneyline-parlay leg, but for the time being, I don’t have a good feel for this game.

San Francisco 49ers vs. Philadelphia Eagles Odds

  • Spread
    49ers -2.5
  • Moneyline
    49ers -146, Eagles +124
  • Total
    46.5

It’s surprising to see the 10-1 Eagles as home underdogs, but the 49ers have been that good. This is also a similar spot for them as it was for the Eagles against the Kansas City Chiefs just two weeks ago — a revenge game against the team that eliminated them in the postseason last year. Not to mention, the 49ers feel they didn’t get a fair shot in the game when both of their quarterbacks suffered injuries.

MORE: NFL Team Over/Under Standings

I expect the 49ers to come out extra motivated here, and despite having two fewer wins, they could be considered the better team.

Pick: 49ers -2.5

Cleveland Browns vs. Los Angeles Rams Odds

  • Spread
    Rams -4.5
  • Moneyline
    Browns +162, Rams -194
  • Total
    39.5

Myles Garrett’s health is a huge question mark for this one, as this Browns’ pass rush could’ve caused a ton of problems for Matthew Stafford. But Garrett’s absence would be a massive loss for Cleveland, and it could take away a huge advantage for the NFL’s best defense. Without him, I’m not sure they can keep this a close game behind Dorian Thompson-Robinson.

Pick: Lean Rams -4.5

Kansas City Chiefs vs. Green Bay Packers Odds

  • Spread
    Chiefs -6.5
  • Moneyline
    Chiefs -290, Packers +235
  • Total
    42.5

Jordan Love has been playing really good football lately, but playing against this Chiefs defense will easily be his biggest test to date. The Chiefs on Sunday proved that their lackluster offensive performance against the Eagles was an anomaly and that they’re still capable of putting up a ton of points. Isiah Pacheco should have his way with this Packers run defense as well.

Pick: Chiefs -6.5

Cincinnati Bengals vs. Jacksonville Jaguars

  • Spread
    Jaguars -7.5
  • Moneyline
    Bengals +315, Jaguars -400
  • Total
    38.5

This Jaguars offense is in a groove right now, and they get to face a Bengals defense that has been overrated all season long and just became the first team to surrender 400+ yards of offense to the Steelers since 2020. Meanwhile, Jake Browning showed flashes against the Steelers on Sunday, and if Tee Higgins returns, that should give this offense a much-needed boost. A rare prime-time over for me (for now).

Pick: Over 38.5

Our Betting Lines page has the freshest lines and promos to get BANG for your buck. PFN’s FREE Parlay Calculator and Betting Odds Calculator are also available for your betting process! New to sports betting? Check out our guide on How to Bet on the NFL. Visit our Sports Betting Legal Tracker on how to bet legally in the U.S.

Listen to the PFN Betting Podcast

Listen to the PFN Betting Podcast! Click the embedded player below to listen, or you can find the PFN Betting Podcast on iTunes, Spotify, and all major podcast platforms. Be sure to subscribe and leave us a five-star review!

Join the Conversation!

Related Articles