As the NFL heads into Week 10, several teams are dealing with some major injury questions. The 2025 NFL season is now just entering November, so teams are facing crunch time for healthy bodies.
For NFL fans and fantasy managers, the injury list is critical for understanding who might be out or limited in the upcoming games. Here’s a breakdown of the notable injuries and what you need to know about them heading in.
Week 10 NFL Injury Report
Bucky Irving and Chris Godwin, WRs, Tampa Bay Buccaneers
Update 11/7: WRs Bucky Irving, who has been dealing with foot and shoulder injuries and Chris Godwin, who has been dealing with a fibula injury, will not play in Week 10 against the New England Patriots.
Update 11/6: WRs Bucky Irving and Chris Godwin did not practice on Thursday.
On Wednesday, neither wide receiver Bucky Irving nor fellow WR Chris Godwin was seen on the practice field for the Buccaneers.
ESPN NFL Insider Adam Schefter reported on their absences in a post on X.
Buccaneers RB Bucky Irving and WR Chris Godwin were not spotted at practice today, raising questions about the availability of both for Sunday’s game against the Patriots.
— Adam Schefter (@AdamSchefter) November 5, 2025
Tampa Bay has a big game coming up on Sunday against Drake Maye and the New England Patriots. Without two of his key receivers on the field, Tampa Bay quarterback Baker Mayfield will have to turn to others.
According to Bucs Gameday editor River Wells, Buccaneers head coach Todd Bowles said on Wednesday that “Bucky Irving and Chris Godwin are ‘coming along’ and working on rehab in the morning – he says that it’s ‘possible’ they return to practice but that ‘we’ll see what tomorrow brings.'”
In the PFSN NFL Offense Impact metrics, Tampa Bay has an Offense Impact Score of 71.4 and grades out at C-. If the Bucs can get Irving and Godwin back soon, then those numbers might improve.
James Cook, RB, Buffalo Bills
Update 11/6: Bills RB James Cook told Kay Adams of the “Up & Adams Show” on Thursday that “I’m ready to go. I’ll be out there when it’s time to play on Sunday.”
Bills running back James Cook was out of practice on Wednesday due to foot and ankle injuries. Whether he will be ready for Buffalo’s upcoming game remains to be seen.
Bills on SI reporter Alex Brasky posted on X that Bills head coach Sean McDermott said this about Cook’s injuries, which happened last Sunday against the Kansas City Chiefs. “Came up during the game, just sore in the last couple days after the game,” McDermott said.
According to the PFSN NFL RB Impact metrics, Cook has a 95.4 RB Impact Score and grades out with an A.
C.J. Stroud, QB, Houston Texans
In last Sunday’s loss to the Denver Broncos at NRG Stadium in Houston, Texans starting quarterback C.J. Stroud suffered a concussion in the first half. Stroud did not return to the game as Texans head coach DeMeco Ryans replaced Stroud with backup Davis Mills.
On Wednesday, Ryans stated that Stroud will not play in this week’s game against the Jacksonville Jaguars due to the concussion. Ryans will put the Texans’ offense back in Mills’ hands.
Texans QB C.J. Stroud ruled out in Week 10 vs. Jaguars. Davis Mills will start. pic.twitter.com/dAmn2HzBtG
— NFL (@NFL) November 5, 2025
According to the PFSN NFL QB Impact metrics, Stroud has a 75.1 QB Impact Score and grades out with a C.
Trey Benson, RB, Arizona Cardinals
The Cardinals have been without running back Trey Benson for four games as he’s been on Injured Reserve due to a knee injury.
On Wednesday, Cardinals head coach Jonathan Gannon offered an update on Benson’s status. Gannon said Benson is progressing, but he won’t be practicing with the team on Wednesday.
Jonathan Gannon provides an update on Trey Benson:
“He’s doing well. He’s progressing.”
(@AZCardinals Press Pass) #BirdGang pic.twitter.com/cxegrAhSIA
— SleeperCardinals (@SleeperAZCards) November 5, 2025
According to the PFSN NFL Offense Impact metrics, the Cardinals have an Offense Impact Score of 72.4 and grade out at C-.
Kyler Murray, QB, Arizona Cardinals
The Cardinals defeated the Dallas Cowboys on Monday night without starting quarterback Kyler Murray. Backup Jacoby Brissett started in Murray’s place.
Cardinals head coach Jonathan Gannon named Brissett as the team’s starting QB on Tuesday. Then, on Wednesday, the team announced that Murray was going on Injured Reserve due to his foot injury.
Gannon offered more details around the decision to put Murray on IR when he met reporters on Wednesday, according to NFL Network Insider Tom Pelissero.
Jonathan Gannon on why Kyler Murray (foot) is going on IR: “Feel like that’s the best thing for him and for us. … He’s not healthy enough to play. He needs to get healthy so he can get back to playing football, so that’s what we’re doing.”
— Tom Pelissero (@TomPelissero) November 5, 2025
According to the PFSN NFL QB Impact metrics, Murray has a 75.2 QB Impact Score and grades out to a C. As for Brissett, he has an 82.8 QB Impact Score and grades out to a B-. Murray will now be out for 4 weeks, and his status will be reviewed then.
Jayden Daniels, QB, Washington Commanders
On Friday, the Washington Commanders revealed that starting quarterback Jayden Daniels, who suffered a brutal-looking injury to his left (non-throwing) elbow on Sunday night, will not go on injured reserve.
Schefter posted on X about the team’s decision.
Commanders do not expect to place QB Jayden Daniels on injured reserve, per sources. They will reevaluate his injury during the bye week. pic.twitter.com/BMkWn25o74
— Adam Schefter (@AdamSchefter) November 7, 2025
“Commanders do not expect to place QB Jayden Daniels on injured reserve, per sources,” Schefter wrote. “They will reevaluate his injury during the bye week.”
Saquon Barkley, RB, and A.J. Brown, WR, Philadelphia Eagles
Update 11/7: Eagles running back Saquon Barkley and wide receiver A.J. Brown were spotted on the practice field on Friday, apparently looking like they are good to go on Sunday.
Second day in a row A.J. Brown (hamstring) and Saquon Barkley (groin) are practicing. Cam Jurgens (knee) doesn’t appear to be practicing once again. A.J. said he is playing in the #Eagles game Monday night. pic.twitter.com/GF1gce9xHh
— Dave Uram (@MrUram) November 7, 2025
Update 11/6: Philadelphia Eagles running back Saquon Barkley, who has been dealing with a groin injury, was at Eagles practice on Thursday. Wide receiver A.J. Brown, who has been dealing with a hamstring injury, was there, too. Cornerback Adoree’ Jackson, who has been dealing with a concussion, also showed up for Thursday’s practice.
Brock Purdy, QB, and Ricky Pearsall, WR, San Francisco 49ers
Update 11/7: On Friday, the San Francisco 49ers said that backup quarterback Mac Jones will start once again in place of starter Brock Purdy. Purdy has been listed as questionable due to his turf toe injury that continues to give him a lot of trouble.
49ers QB Mac Jones will start again Sunday in place of Brock Purdy, who is listed as questionable for Sunday’s game against the Rams due to his turf toe injury. pic.twitter.com/lGDbv0Yy2O
— Adam Schefter (@AdamSchefter) November 7, 2025
Update 11/6: 49ers general manager John Lynch said on Thursday that QB Brock Purdy is making good progress and will be evaluated at the end of the week.
Purdy has an opportunity to be suited up as the backup QB IF he is healthy and Lynch noted: “That could be the next step to getting back to the #1 spot.” Also, WR Ricky Pearsall was not at 49ers practice on Thursday.
49ers starting quarterback Brock Purdy will be limited in practice on Wednesday due to his toe injury, according to a post on X from Schefter.
Also, wide receiver Ricky Pearsall is still not practicing as he’s recovering from a knee injury. In addition, wide receiver Brandon Aiyuk is scheduled to return from his knee injury later this season.
Aaron Jones Sr., RB, Minnesota Vikings
On Friday, the Minnesota Vikings listed running back Aaron Jones Sr. as questionable for the team’s Week 10 play. Jones has been dealing with a shoulder injury, but recent comments from him make it sound like he could be on the field to help out Vikings starting quarterback JJ McCarthy.
Brian Thomas Jr., WR, Jacksonville Jaguars
On Friday, the Jacksonville Jaguars ruled out wide receiver Brian Thomas Jr. from Sunday’s game against the Houston Texans at NRG Stadium in Houston due to a high ankle sprain injury.
Jaguars wide receiver Brian Thomas Jr. will miss Sunday’s game vs. the Texans due to his high ankle sprain. pic.twitter.com/Bxr4FWcJ3C
— Adam Schefter (@AdamSchefter) November 7, 2025
Schefter had an update on Thomas’ status on Friday.
Puka Nacua, WR, Los Angeles Rams
Rams wide receiver Puka Nacua, who has been dealing with a rib injury, should be good to go on Sunday against the San Francisco 49ers, Rams head coach Sean McVay said on Wednesday, according to a post on X from Schefter.
Kayshon Boutte, WR, and Rhamondre Stevenson, RB, New England Patriots
Update 11/7: Patriots head coach Mike Vrable on Friday ruled out wide receiver Kayshon Boutte and running back Rhamondre Stevenson, along with linebacker Christian Elliss, for Sunday’s game.
Mike Vrabel arrives and says RB Rhamondre Stevenson (toe), WR Kayshon Boutte (hamstring) and LB Christian Elliss (hip) are out for Sunday. pic.twitter.com/0Db04PQECM
— Mike Reiss (@MikeReiss) November 7, 2025
Update 11/6: Patriots WR Kayshon Boutte and RB Rhamondre Stevenson did not practice on Thursday.
Patriots wide receiver Kayshon Boutte, who has been dealing with a hamstring injury, was not scheduled to practice on Wednesday, according to Patriots head coach Mike Vrabel.
In addition, running back Rhamondre Stevenson, who’s dealing with a toe injury, and linebacker Christian Elliss, who is dealing with a hip injury, also were not scheduled to practice on Wednesday.
Marvin Mims Jr., WR, Denver Broncos
Update 11/6: WR Marvin Mims Jr. will not play on Thursday night. On Wednesday, Broncos wide receiver Marvin Mims Jr., who has been dealing with a concussion, did not practice with the team, according to a post from NFL Network Insider Mike Garafolo.
Travis Hunter, WR-CB, Jacksonville Jaguars
Last Friday, Jacksonville Jaguars rookie two-way star Travis Hunter was placed on Injured Reserve after injuring his knee in practice last Thursday.
According to Schefter, last Friday, “Initial testing revealed that Jaguars WR/CB Travis Hunter’s ACL is intact, per source. Hunter is going through additional testing to determine the extent of the injury and how long he’ll be sidelined, and no answers are expected before next week.”
Carson Wentz, QB, Minnesota Vikings
Minnesota Vikings backup quarterback Carson Wentz is out for the rest of the 2025 NFL season due to an injury in his non-throwing left shoulder.
Carson Wentz talking about his injury, the end of his season, and last Thursday’s game.
“I’m not an idiot. I knew what I was signing up for.” pic.twitter.com/cjO8EASnlq
— Will Ragatz (@WillRagatz) October 29, 2025
Wentz gutted it out in his final start this season, but eventually had to come out of Minnesota’s game against the Los Angeles Chargers. In the PFSN NFL QB Impact metrics, Wentz finished his season with a score of 72.3 and graded out at C-.
Malik Nabers, WR, New York Giants
New York Giants head coach Brian Daboll said last week that wide receiver Malik Nabers hasn’t had surgery on his torn ACL yet. According to Ari Meirov of The 33rd Team, Nabers will have the procedure performed once the swelling around his knee subsides.
Darren Waller, TE, Miami Dolphins
Miami Dolphins tight end Darren Waller, who has been dealing with a pec injury, was recently placed on injured reserve. Waller came out of retirement this season to play for the Dolphins.
Joe Mixon, RB, Houston Texans
Joe Mixon remains on the Texans’ injured reserve list. The Texans’ running back has been dealing with a foot injury since before the season started.
Charvarius Ward Sr., CB, Indianapolis Colts
Indianapolis Colts cornerback Charvarius Ward Sr., who suffered a concussion, is still on injured reserve.
Omarion Hampton, RB, Los Angeles Chargers
Omarion Hampton of the Los Angeles Chargers suffered an ankle injury in Week 5 during a 27-10 loss to the Commanders at SoFi Stadium. He remains on Injured Reserve.
Braelon Allen, RB, New York Jets
Braelon Allen of the New York Jets is still on Injured Reserve with a knee injury.
Antonio Gibson, RB, New England Patriots
Antonio Gibson of the New England Patriots, who tore his ACL, remains on Injured Reserve.
Out for the Year
- James Conner, RB, Arizona Cardinals (Foot)
- Miles Sanders, RB, Dallas Cowboys (Ankle/Knee)
- Malik Nabers, WR, New York Giants (Knee)
- Antonio Gibson, RB, New England Patriots (Knee)
- Carson Wentz, QB, Minnesota Vikings (Non-throwing shoulder)
- Spencer Shrader, K, Indianapolis Colts (Knee)
- Patrick Jones II, OLB, Carolina Panthers (Back)
- Tyreek Hill, WR, Miami Dolphins (Knee)
- Trishton Jackson, WR, Arizona Cardinals (Thumb)
- Emory Jones, QB, Atlanta Falcons (Concussion)
- Dayton Wade, WR, Baltimore Ravens (Rib)
- Jonathon Brooks, RB, Carolina Panthers (Knee)
- Deion Hankins, RB, Chicago Bears (Shoulder)
- Cade McDonald, WR, Cleveland Browns (Undisclosed)
- Kye Robichaux, RB, Detroit Lions (Undisclosed)
- Irv Smith, TE, Houston Texans (Ankle)
- Brevin Jordan, TE, Houston Texans (Knee)
- D.J. Montgomery, WR, Indianapolis Colts (Undisclosed)
- Joshua Cephus, WR, Jacksonville Jaguars (Undisclosed)
- Keaontay Ingram, RB, Kansas City Chiefs (Undisclosed)
- Najee Harris, RB, Los Angeles Chargers (Achilles)
- Alexander Mattison, RB, Miami Dolphins (Neck)
- Jalin Conyers, TE, Miami Dolphins (Leg)
- Rondale Moore, WR, Minnesota Vikings (Knee)
- Lan Larison, RB, New England Patriots (Foot)
- Deneric Prince, RB, New England Patriots (Undisclosed)
- Bub Means, WR, New Orleans Saints (Leg)
- Bryce Ford-Wheaton, WR, New York Giants (Achilles)
- Johnny Wilson, WR, Philadelphia Eagles (Knee)
- Donald Parham Jr, TE, Pittsburgh Steelers (Achilles)
- Trent Taylor, WR, San Francisco 49ers (Undisclosed)
- Kenny McIntosh, RB, Seattle Seahawks (Knee)
- Jaden Smith, WR, Tampa Bay Buccaneers (Undisclosed)
- Will Levis, QB, Tennessee Titans (Shoulder)
- Austin Ekeler, RB, Washington Commanders (Achilles)
- Tyree Jackson, TE, Washington Commanders (Undisclosed)
