Giants vs. 49ers Final Score, Results, and Highlights: Brock Purdy and Deebo Samuel Dominate New York on Thursday Night Football

Amazon Prime’s Thursday Night Football returned, and as expected, we witnessed one of the more lopsided games of this young NFL season. The New York Giants came into San Francisco to try and turn around a rocky season so far. Well, unfortunately for them, they ran into a buzzsaw, otherwise known as Brock Purdy and Deebo Samuel.

Giants vs. 49ers Final Score and Results

Highlights and Analysis

Fourth Quarter: 49ers 30, Giants 12

11:17 p.m. ET: The 49ers did not pick up the first down but forced the Giants to use all their timeouts. The Giants have also thrown in the towel, putting backup QB Tyrod Taylor into the game. 49ers get the win 30-12 and cover the 10.5-point spread.

11:14 p.m. ET: As the Giants tried to make this a bit more interesting near the end of the game, Daniel Jones threw his first INTERCEPTION of the night when targeting Waller. With only a little over three minutes left, the 49ers will try to just run the clock.

Game. Set. Match.

The #49ers will move to 3-0 on the season while the #Giants fall to 1-2. pic.twitter.com/elTn1FYusL

— Pro Football Network (@PFN365) September 22, 2023

11:05 p.m. ET: Samuel not only returned to the game, but he also just scored what is likely the game-sealing TOUCHDOWN. It was a beautiful throw from Purdy for a 27-yard TD.

11:00 p.m. ET: Samuel is back on the sideline and seems to be fine! 49er fans can breathe a sigh of relief.

10:55 p.m. ET: The 49ers needed to do two things in this game — 1) beat an inferior opponent, and 2) come away without any injuries. The first seems to be happening, but the second is now in doubt as Deebo Samuel goes into the tent after making a catch and pushing his way for a few extra yards.

10:45 p.m. ET: Even though there were a number of penalties to extend the drive, the 49ers come up with just a FIELD GOAL. The Niners are now up 11. Remember the betting line closed at San Francisco -10.5.

Third Quarter: 49ers 20, Giants 12

10:42 p.m. ET: The Giants’ defense clearly wasn’t listening to my below pep talk. Kittle has dominated this drive and now has the team close to the end zone after a massive 29-yard catch that was extended thanks to some impressive stiff arms.

10:31 p.m. ET: The Giants failed to do anything offensively and are now punting the ball back to the 49ers. This feels like a huge series. If the Giants’ defense can’t stop the 49ers’ offense, this one might just be out of reach. Which is shocking to say with an entire quarter left, but this Giants offense just has no answer for the 49ers.

10:23 p.m. ET: After another penalty, the 49ers were five yards away from another TD. But, surprisingly enough, the Giants’ defense managed to keep San Fran and more importantly CMC out of the end zone. The 49ers settle for a FIELD GOAL. And although this game feels like the 49ers have dominated, they are only up by one possession. If this Giants team can figure something out on this next offensive possession against one of the best defenses in the NFL, we could head into the fourth quarter with a tied game.

10:15 p.m. ET: DEEBO SAMUEL! Sheesh, what a response from the 49ers. Purdy finds Samuel and he goes long after breaking FOUR tackles. Sheesh. And guess what, the 49ers are now just outside the red zone again.

When Deebo Samuel is above his average for receiving yards (50 yards), the #49ers are 5-2 (.714) since the 2022 season — tied for 14th-best of 71 qualified NFL WRs (via @IE_NFL).

Deebo has 80+ yards tonight.pic.twitter.com/rlZtlcT6l9

— Pro Football Network (@PFN365) September 22, 2023

10:11 p.m. ET: Dare I say that we have a game? The Giants, who profited from a nearly 30-yard pass interference penalty, took advantage of a sleepy 49ers defense to get a TOUCHDOWN. It wasn’t pretty, but the Giants are on the board and have cut the lead to just five after a failed two-point conversion attempt.

9:58 p.m. ET: No, the Giants did not suddenly surge. Their first drive ends with a three-and-out after only one first down.

9:55 p.m. ET: The Giants start the second half with the ball. Let’s see if they have the same second-half surge they did last week against the Cardinals.

Second Quarter: 49ers 17, Giants 6

9:36 p.m. ET: Gano knocks down a 56-yard field goal to bring the Giants within 11. The 49ers have outgained New York 244 yards to 88. They have also doubled their time of possession.

9:26 p.m. ET: The drive continues for the 49ers and thanks to a roughing the passer penalty, they sat just five yards from the end zone. Well, when San Fransico is this close to the endzone, you can basically guess what they are going to do next. Yes, Christian McCaffrey rushed for a TOUCHDOWN. That is the 12th straight game with a TD for CMC and the 49ers are now up 14. Oh, and McCaffrey was -220 for an anytime TD, so congrats to anyone who laid the juice.

9:20 p.m. ET: Is it just me, or do the 49ers feel like one of the luckiest teams in the league? After completing whiffing on Trey Lance with the third overall pick, they found a diamond in the rough with Mr. Irrelavant. Then, he goes on to do things like the below clip.

When it’s your night pic.twitter.com/tRvL3S0YJy

— trey wingo (@wingoz) September 22, 2023

9:11 p.m. ET: Quick three-and-out from the Giants and the 49ers are already driving with their next possession. McCaffrey does his best Derrick Henry impression and puts on a show with a massive stiff arm on a 12-yard run.

9:04 p.m. ET: Fantasy managers, close your eyes. The first TOUCHDOWN of the game goes to… Ronnie Bell? Well, it isn’t Kittle or McCaffrey, but it still counts. Purdy connects on a short pass to Bell, and the 49ers are now up 10-3.

9:01 p.m. ET: The 49ers continue to convert on third down. First, Samuel took a screen pass and raced for a 30-yard gain to the New York 47. Then, McCaffrey broke another short pass for 15 on a 3rd and 13. The 49ers are again in the red zone.

8:50 p.m. ET: As expected, the 49ers’ pass rush finally got to Jones as Nick Bosa, fresh off his new contract, takes down the Giants QB deep on their side of the field for a 10-yard sack. Also, how was this not a safety?

This Nick Bosa guy is pretty good. pic.twitter.com/3jVgcrSXGk

— Pro Football Network (@PFN365) September 22, 2023

First Quarter: 49ers 3, Giants 3

8:44 p.m. ET: Hey now. Could it be that we might actually have a game tonight? The 49ers were 10-point favorites in this one, and with the Giants having gone down by more than 20 points in each game this season, San Fran was expected to run away with this one early. Well, it is only 3-3 after the first quarter, and the Giants’ defense just forced a quick three-and-out. New York will start the second quarter with the ball.

8:36 p.m. ET: The Giants were able to move the ball downfield with quick passes as they tried to keep their QB alive. The 49ers’ pass rush put pressure on Jones nearly every play, but the dink and dunk strategy was just good enough to get New York into FIELD GOAL range. Graham Gano ties the game up at three apiece late into the first quarter.

8:31 p.m. ET: With Saquon Barkley out today, Matt Breida gets the starting duties for the Giants. It will be a tall task for Breida, especially with the makeshift offensive line that New York is putting on the field tonight.

8:26 p.m. ET: The Giants have surprised, putting pressure on Purdy early. They nearly sacked him twice, and on both plays, Purdy nearly threw interceptions. The 49ers need to settle for a short FIELD GOAL to get the scoring started in this one.

8:22 p.m. ET: The 49ers have methodically gone down the field to put themselves right outside of the red zone. McCaffrey has already touched the ball four times, and Purdy has found both Samuel and Jauan Jennings for big plays. Let’s also take a minute while we wait to appreciate how good the 49ers’ throwback uniforms look.

Those throwbacks 😍 pic.twitter.com/9DaTcwncXy

— Pro Football Network (@PFN365) September 22, 2023

8:18 p.m. ET: First play of the game starts with a Christian McCaffrey rushing attempt. Without Brandon Aiyuk, who was ruled inactive with an injury ahead of the game, QB Brock Purdy will need to rely heavily on the ground game and other weapons like George Kittle and Deebo Samuel.

How To Watch Giants vs. 49ers Thursday Night Football

Thursday Night Football stays on Prime Video this week. Fans can stay tuned into Amazon’s video streaming service all season long for the Thursday night showdowns, except Thanksgiving week when NBC returns for a one-off takeover. Here’s how to watch the NFL game tonight.