Giants vs. 49ers Predictions, Picks, Odds Today: Can Giants Keep Up Without Saquon Barkley?

The 49ers are heavy favorites against the Giants without Saquon Barkley, but will they cover? We look at the odds and give our Giants vs. 49ers predictions.

Last week, the New York Giants avoided a disastrous 0-2 start to the season with a 21-point comeback against the Arizona Cardinals.

After an inspiring victory against perhaps the worst team in the league, however, they now have to play against the San Francisco 49ers on the road in a short week. A greater challenge, to say the least.

The Giants vs. 49ers is one of three NFL Week 3 matchups in which there is a double-digit point spread, as San Francisco is a heavy favorite in their home opener against a team without Saquon Barkley tonight.

The Giants vs. 49ers odds, however, have remained mostly the same all week. Let’s take a look at the rest of the betting lines and give out our Giants vs. 49ers predictions.

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New York Giants vs. San Francisco 49ers Betting Lines, Start Time, and More

All odds are from DraftKings Sportsbook unless stated otherwise.

  • Spread
    49ers -10
  • Moneyline
    Giants +410, 49ers -550
  • Over/Under
  • Game Time
    8:15 p.m. ET
  • Location
    Levi’s Stadium
  • How To Watch
    Amazon Prime Video

Giants vs. 49ers Predictions

Bearman: We know going into this matchup that San Francisco has one of the better defenses in the league, and the Giants had next to nothing on offense for the first six quarters of the season.

Now, Daniel Jones and Co. woke up in the second half vs. Arizona, but you have to wonder if that was more a bad team protecting a lead or if the Giants figured something out. Either way, they now play against the Niners without Barkley.

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San Francisco has scored 30 points in both of their games, so that scares me off the game total. As a result, I will play the Giants’ team total under.

Jones has rushed for 43 yards and 59 yards in the first two games this season. Without Barkley, there should be more designed running plays for him. I’ll go over his rushing total as well.

Giants vs. 49ers Picks: Giants team total under 16.5 (-108 at DraftKings), Daniel Jones over 38.5 rushing yards (-115 at DraftKings)

Blewis: The Giants had their biggest comeback in franchise history last week, but it was against the Cardinals. As impressive as the comeback was, trailing by 21 points to this Cardinals team in the first half is almost equally pathetic.

The 49ers, you could argue, look like the best team in the NFL right now. They’re 2-0 straight up and would be 2-0 ATS if not for Sean McVay’s inexplicable decision to play for the cover in the final seconds last week.

On a short week in which both teams are banged up offensively, I’m going to go with the under. This is also a huge mismatch between the Giants’ offensive line and the 49ers’ pass rush.

We saw how badly the Dallas Cowboys dominated the G-Men in Week 1, and the 49ers’ defensive line is almost as talented.

I also expect Kyle Shanahan to play this one a bit conservatively. He already admitted this week that they need to keep Christian McCaffrey fresh and get Elijah Mitchell more involved. What better opportunity than on a short week as double-digit favorites?

Giants vs. 49ers Pick: Under 44.5 (-108 at DraftKings)

Soppe: We know the 49ers boast an intimidating defense, and we know the Giants will be without Barkley, so how can we leverage that information into cashing a bet?

“Matchups make fights.” It may be cliché, but that doesn’t mean it’s inaccurate. Kenny Pickett ranked 21st in average depth of throw in Week 1 against the 49ers, and last week against San Fran, Matthew Stafford ranked 26th.

Daniel Jones (8) leaves the field after defeating the Arizona Cardinals at State Farm Stadium.
Sep 17, 2023; Glendale, Arizona, USA; New York Giants quarterback Daniel Jones (8) leaves the field after defeating the Arizona Cardinals at State Farm Stadium.

I don’t think that’s a coincidence. Jones currently ranks outside of the top 15 in average depth of throw this season, producing these aDOTs for his primary weapons:

  • Jalin Hyatt: 30.0 yards
  • Darius Slayton: 15.2
  • Darren Waller: 8.9
  • Sterling Shepard: 7.5
  • Isaiah Hodgins: 7.5
  • Parris Campbell: 4.1

Campbell has been on the field for roughly two-thirds of New York’s plays in each of the first two games, and with him being an option in the short passing game, he should see his fair share of looks.

He owns a career catch rate north of 66%, and with the Giants as a 10-point dog, it’s reasonable to assume they will be in a pass-heavy game script.

Given Campbell’s career catch rate and yards per catch, five targets (he saw six last week) is the number we need to get to for us to put ourselves in a good spot.

Giants vs. 49ers Pick: Parris Campbell over 28.5 rush + receiving yards (-115 at DraftKings)

Katz: This is a tricky one. It’s tough to make any calls on the 49ers’ pass catchers because it could be anyone’s game any given week. There are a few things I’m looking at here.

McCaffrey just saw a 100% snap share. That is going to come down on a short week. His rush attempts under 17.5 is interesting.

I’m also feeling a George Kittle game. However, that’s a hunch because there’s no evidence suggesting it.

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What I’m targeting is the Giants’ running back situation. Matt Breida has exactly one game in a feature role since 2018. It was Week 18 of last season with the Giants resting starters … he saw four carries.

Breida will be the lead back, but this is an awful matchup. I’m expecting a bit of a timeshare with Gary Brightwell and possibly Eric Gray, too. Plus, even if I’m wrong, I can certainly envision Breida taking 10-12 carries and going nowhere with them.

Giants vs. 49ers Pick: Breida under 32.5 rushing yards (-115 at DraftKings)

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