No. 19 Louisville (7-2, 4-2) will host ACC opponent Clemson (4-5, 3-4) in a Friday night matchup. Both teams enter this game with plenty to prove as the regular season winds down.
Clemson is coming off a 24-10 home win over Florida State, while Louisville looks to bounce back after a heartbreaking 29-26 overtime loss to Cal. Despite the defeat, the Cardinals have shown resilience all season, and this game offers a chance to regain momentum and strengthen their College Football Playoff hopes.
Louisville vs. Clemson Details
- Date: Nov. 14, 2025
- Game time: 7:30 p.m. ET
- Location:Â L&N Federal Credit Union Stadium, Louisville, Ky.
- Predicted weather at kick:Â 63 degrees
- How to watch:Â ESPN
Louisville vs. Clemson Head-to-Head Record
Friday will mark the 10th all-time meeting between the Tigers and the Cardinals. The series began on Oct. 11, 2014, when Clemson beat Louisville by 23-17.
The Tigers dominated the head-to-head series, winning eight straight matchups before the Cardinals flipped the script last season with a 33- 21 victory at Clemson. Louisville will look to build on that momentum and earn back-to-back wins over Clemson for the first time in program history.
Louisville vs. Clemson Grades
- Louisville (76.5, C)
- Clemson (80.4, B-)
- Louisville (86.5, B)
- Clemson (82.4, B-)
- Louisville (77.6, C+)
- Clemson (75.5, C)
- Miller Moss, Louisville (77, C)
- Cade Klubnik, Clemson (80.4, B)
- Keyjuan Brown, Louisville (75.5, C)
- Adam Randall, Clemson (83.1, B)
- Chris Bell, Louisville (80.3, B-)
- Bryant Wesco Jr., Clemson (79.6, C+)
- Jaleel Skinner, Louisville (73.3, C)
- Christian Bentancur, Clemson (77.5, C+)
- Clev Lubin, Louisville (85.1, B)
- T.J. Parker, Clemson (77.6, C+)
- Rene Konga, Louisville (84.3, B)
- Peter Woods, Clemson (78, C+)
- TJ Quinn, Louisville (74.3, C)
- Sammy Brown, Clemson (78.6, C+)
- Jabari Mack, Louisville (82.1, B-)
- Avieon Terrell, Clemson (87.4, B+)
- Antonio Watts, Louisville (81.8, B-)
- Ricardo Jones, Clemson (77.4, C+)
Louisville vs. Clemson Prediction
Louisville holds home-field advantage and extra motivation after dropping five spots in last week’s AP poll. Expect the Cardinals to play with urgency as they aim to climb into playoff contention and avoid another ACC setback.
Quarterbacks Cade Klubnik and Miller Moss will be key in determining the outcome. Klubnik has thrown 2,136 yards and 14 touchdowns, adding two rushing touchdowns, while Moss has thrown 2,132 yards and 11 touchdowns, adding five rushing touchdowns.
Both seniors need to step up not only to lead their teams but also to boost their draft stock. Moss and the Cardinals’ offense should find their rhythm early on to secure a statement win.
Prediction: Louisville 31, Clemson 24
