As the NFL heads into Week 6, several teams deal with significant injury questions after a physically challenging first month and a half.
For NFL fans and fantasy managers, the injury list is critical for understanding who might be out or limited in the upcoming games. Here is a breakdown of the notable injuries and what you need to know about them.
Week 6 NFL Injury Report
Saquon Barkley, RB, Philadelphia Eagles
Saquon Barkley appeared on the Eagles’ DNP (Did Not Practice) list on Monday, October 6, due to a knee injury. Barkley played a significant role in the Eagles’ 21-17 loss to the Denver Broncos on Sunday.
After news of Barkley’s absence from the Eagles’ practice, NFL Network Insider Ian Rapoport offered an update on his status.
Source on Saquon Barkley: He had general soreness coming out of the game and fully expects to play Thursday night against the #Giants.
— Ian Rapoport (@RapSheet) October 6, 2025
Apparently, Barkley was only experiencing some soreness on Monday. Barkley played on Thursday night in the Eagles’ 34-17 loss to the New York Giants on Thursday Night Football.
Omarion Hampton, RB, Los Angeles Chargers
Omarion Hampton suffered an ankle injury in Sunday’s 27-10 loss to the Washington Commanders at SoFi Stadium. Chargers HC Jim Harbaugh announced on Monday that Hampton will go on Injured Reserve, meaning he’ll miss the next four weeks.
“Chargers HC Jim Harbaugh said RB Omarion Hampton will be placed injured reserve, sidelining him a minimum of four games due to his ankle injury,” ESPN NFL Insider Adam Schefter posted on Monday.
Chargers HC Jim Harbaugh said RB Omarion Hampton will be placed injured reserve, sidelining him a minimum of four games due to his ankle injury.
— Adam Schefter (@AdamSchefter) October 6, 2025
Hampton’s injury is just another major setback for the Chargers’ running back corps. The team already lost Najee Harris for the season, so they’re going to have to look elsewhere for rushing yards.
Update 10/8: Chargers officially placed Hampton on Injured Reserve on Wednesday, according to Schefter. The team also signed RB Kimani Vidal to the active roster from their practice squad. Signed RB Nyheim Hines to their practice squad.
Bucky Irving, RB, Tampa Bay Buccaneers
Bucky Irving has been dealing with a strained foot, Schefter reported on Sunday, but he’s also suffering from a shoulder subluxation injury. That shoulder injury might be more painful for Irving, who Buccaneers quarterback Baker Mayfield looks upon as a big contributor to the team’s offense.
Bucky Irving – shoulder/foot injury update pic.twitter.com/ELbrZ0huVW
— Jesse Morse, M.D. (@DrJesseMorse) October 6, 2025
Irving did not play in Sunday’s victory over the Seattle Seahawks and he’s not due back for Tampa Bay’s game against the San Francisco 49ers. This will be a situation that Tampa Bay head coach Todd Bowles will have to monitor as the week progresses.
Update 10/10: Irving was ruled out of Sunday’s game on Friday. Update 10/9: Irving was not seen on the field on Thursday during the portion open to the media, according to Rick Stroud of the Tampa Bay Times. Update 10/8: Irving was not seen at Wednesday’s walkthrough. Bowles did offer a brief update on Irving’s status: “It’s still his ankle and still his shoulder. He’s getting better by the day, so we’ll see.” Update 10/7: While the Buccaneers have not made an official announcement, Dr. Jesse Morse, in a post on X, said that it’s possible Irving returns this week.
Joe Mixon, RB, Houston Texans
There’s been no new movement in the news about Joe Mixon. He has been dealing with a foot injury since before the season started and has been on the Texans’ Injured Reserve.
Mixon did not play on Sunday against the Baltimore Ravens. On September 29, Texans head coach DeMeco Ryans indicated that Mixon was not ready to return at that time. According to Aaron Wilson of KPRC-TV in Houston, the timetable for Mixon’s return will be much longer if he plays at all this season.
Update 10/7: Texans general manager addressed Mixon’s situation on Tuesday in a press conference.
Nick Caserio talking about RB Joe Mixon:
“Over the next few weeks we should have a better idea, he’s making progress” pic.twitter.com/pTVmdOsf9d
— Jacob (@TexansJacob) October 7, 2025
“Over the next few weeks we should have a better idea, he’s making progress,” Caserio said. The Texans have a bye week in Week 6.
Lamar Jackson, QB, Baltimore Ravens
Lamar Jackson did not play on Sunday against the Houston Texans because he has been dealing with a hamstring injury. Cooper Rush started at quarterback for the Ravens in the Texans’ huge 44-10 victory in Baltimore on Sunday.
Harbaugh: Snoop Huntley will be considered at QB if Lamar Jackson (hamstring) can’t play Week 6.
— Underdog NFL (@UnderdogNFL) October 6, 2025
On Monday, Ravens head coach John Harbaugh said that Snoop Huntley would be considered as the starting QB for his team if Jackson cannot go.
Besides Jackson, the Ravens played the Texans without cornerbacks Chidobe Awuzie and Marlon Humphrey, tackle Emery Jones Jr., fullback Patrick Ricard, and inside linebacker Roquan Smith.
Update 10/10: Jackson was ruled out on Friday and it’s looking more like Cooper Rush will start for a second straight week. Rush, indeed, will be the starting QB. Additionally, the Ravens ruled out MLB Roquan Smith, FB Pat Ricard, OT. Emery Jones, and CB Chidobe Awuzie. Update 10/9: Jackson did not practice on Thursday, according to ESPN NFL Insider Adam Schefter. Update 10/8: Jackson remained out of practice on Wednesday, according to NFL Network Insider Mike Garafolo. Update 10/7: According to a new story from PFSN, Fox Sports’ Jay Glazer offered a quick update on Jackson’s situation heading into this week. “I was told there’s an outside shot for next week, so they don’t want to shut it down yet,” Glazer said. “But the bye is coming after that, obviously. If they decide to (hold) him out next week, then they get three weeks of rest for him, but they’re not saying he’s out yet for next week.” … The Ravens also added safety C.J. Gardner-Johnson, who recently played with the Houston Texans before being released, to their practice squad.
Spencer Shrader, K, Indianapolis Colts
Spencer Shrader suffered a torn MCL and ACL in his right leg on Sunday while making a PAT try in the second quarter of the Colts’ game against the Las Vegas Raiders. As he swung his leg through, a Raiders player ran into his right leg.
#SpencerShrader @Colts
Right knee injury
Likely MCL
No way to kick with that injury@Raiders punter to locker room too pic.twitter.com/7qy4U2XaoV— David J. Chao – ProFootballDoc (@ProFootballDoc) October 5, 2025
Shrader is now out for the rest of the 2025 NFL season. According to several reports, including one from ESPN, the team is now looking for his replacement.
Update 10/7: The Colts have signed kicker Michael Badgley to their active roster as a replacement for Shrader. Shrader was placed on the Injured Reserve list on Tuesday.
Antonio Gibson, RB, New England Patriots
Update 10/10: Antonio Gibson, who tore his ACL, was officially placed on Injured Reserve on Friday.
Trey Benson, RB, Arizona Cardinals
Schefter reported last week that Trey Benson, the Cardinals’ RB2 to open the season, was placed on Injured Reserve after suffering a knee injury. Benson underwent arthroscopic surgery on his meniscus and will be out between “four and six weeks.”
Cardinals head coach Jonathan Gannon said last week that he expected Benson to return later this season.
David Moore, WR, Carolina Panthers
The Panthers placed David Moore on Injured Reserve last week. Moore suffered an elbow injury and will miss at least four games for Carolina.
RELATED: Panthers Announce Major Update on Jalen Coker’s Injury
Moore was injured on Carolina’s first play from scrimmage in a game against the New England Patriots when he took a jet sweep and ran 12 yards. Patriots cornerback Marcus Jones brought Moore down after grabbing his arm. Moore was carted off the field.
Braelon Allen, RB, New York Jets
Braelon Allen was placed on Injured Reserve last week by the Jets. On that Wednesday, Jets head coach Aaron Glenn said that Allen was dealing with a “pretty significant knee injury.” He’ll be out at least four weeks.
Ja’Marr Chase, WR, Cincinnati Bengals
Update 10/10: Ja’Marr Chase did not practice on Friday due to an illness and has been ruled as questionable for Sunday’s game, Bengals coach Zac Taylor announced.
Brock Purdy, QB, San Francisco 49ers
Brock Purdy has been having a heck of a time getting over a turf toe injury. Backup QB Mac Jones started on Sunday, and, from the looks of it, Purdy is still out.
MAC JONES with the brace on at #49ers practice.
Looking like it’s another Mac Jones week Vs the Bucs. No Brock Purdy in sight 👀⬇️ pic.twitter.com/jKUjXqz5rL
— 49ers & NFL News 24/7 (@49ersSportsTalk) October 6, 2025
At Monday’s 49ers practice, Jones was spotted on the field wearing a left knee brace, but Purdy was not. Adrian Martinez was the only healthy QB at San Francisco’s practice. The 49ers will monitor Purdy’s situation as the week rolls along.
Update 10/10: Purdy did not practice on Friday, but was doing side-field work, according to 49ers Reporter Cam Inman for Bay Area News Group. Update 10/9: Purdy did not practice on Thursday, according to Schefter.
Terry McLaurin, WR, Washington Commanders
Update 10/11: Commanders head coach Dan Quinn ruled McLaurin, along with fellow WR Noah Brown, have been ruled out for Sunday’s game against the Chicago Bears. Update 10/10: Terry McLaurin did not practice with the team on Friday. Update 10/9: McLaurin was seen on the practice field on Thursday but not in pads. Update 10/8: McLaurin did not practice on Wednesday. Update 10/7: The Commanders did not practice on Tuesday. They will return to practice on Wednesday, so there might be an update on McLaurin’s status at that time.
Terry McLaurin has been dealing with a quadriceps injury and did not play on Sunday. On Monday, though, Commanders head coach Dan Quinn offered a positive note regarding McLaurin’s health.
Quinn said he’s “optimistic” about Terry McLaurin for this week and reiterates that he and others — Noah Brown, Sam Cosmi — are trending in the right direction. Having the extra day helps. But, stop me if you’ve heard this one, we’ll find out more later in the week.
— John Keim (@john_keim) October 6, 2025
Quinn sounded “optimistic” about McLaurin’s return but wants to see how the rest of this week pans out. As McLaurin’s supposed return approaches, this situation will likely evolve throughout the week.
CeeDee Lamb and KaVontae Turpin, WRs, Dallas Cowboys
Update 10/10: Lamb and Turpin both have been ruled out of Sunday’s game. Other Cowboys ruled out include OG Tyler Booker. Update 10/9: Lamb was on the practice field again on Thursday, working with resistance cords, according to ESPN Cowboys reporter Todd Archer. Turpin was not at practice on Thursday. Update 10/8: Lamb got in some work on resistance cords during Wednesday’s practice, according to Cowboys reporter Jon Machota for The Athletic. Lamb was listed as a DNP on Wednesday’s team injury report. Machota also reported that Turpin does not expect to play on Sunday. Turpin also was a DNP on Wednesday. The expectation is that Turpin will be back in Week 7 against the Washington Commanders.
CeeDee Lamb, along with fellow Cowboys wide receiver KaVontae Turpin, did not play on Sunday against the New York Jets.
Lamb has been dealing with an ankle injury. While he went through some practices with Dallas last week, he did not play.
Stephen Jones: CeeDee Lamb (ankle), KaVontae Turpin (foot) could be back in next 2 weeks.
— Underdog NFL (@UnderdogNFL) October 6, 2025
According to Cowboys co-owner and chief executive officer Stephen Jones on Monday, Lamb and Turpin, who is dealing with a foot injury, could return in two weeks. There is even hope that Lamb might potentially be able to return this week against Carolina.
J.J. McCarthy, QB, Minnesota Vikings
Update 10/7: The Vikings have a Week 6 bye, so there probably will not be any more news about McCarthy’s availability until the Vikings get back on the practice field.
J.J. McCarthy did not play on Sunday in the Vikings’ game against the Cleveland Browns in London. McCarthy has been trying to overcome a high ankle sprain. With McCarthy out, Vikings head coach Kevin O’Connell turned to Carson Wentz to start at QB.
Jaxson Dart, QB, New York Giants
Update 10/8: Dart was removed from the team’s injury report on Wednesday and played on Thursday night in the Giants’ 34-17 win over the Philadelphia Eagles.
Jaxson Dart, who is dealing with a hamstring injury, was listed as a full go on Tuesday in the Giants’ estimated injury report, according to NFL Network Insider Mike Garafalo. The Giants went through a walkthrough on Tuesday. Dart was listed as limited on Monday.
Terrion Arnold, CB, Detroit Lions
Update 10/10: Terrion Arnold was ruled out of Sunday’s game. Arnold, who has been dealing with a shoulder injury, went to get a second opinion about his shoulder on Tuesday. According to NFL Network Insider Tom Pelissero, Arnold “received positive news on his second opinion, will not need shoulder surgery and is now expected to return this season, per sources.”
Brenton Strange, TE, Jacksonville Jaguars
Update 10/7: Brenton Strange, who is dealing with a quad injury, was placed on Injured Reserve by the Jaguars on Tuesday, meaning he will be out for the 4-1 Jaguars’ next four games.
Tyrone Tracy, RB, New York Giants
Update 10/8: Tyrone Tracy was removed from the Giants’ injury report and was available for Thursday night’s game against the Eagles.
Kyler Murray, QB, Arizona Cardinals
Update 10/10: Kyler Murray returned to practice on Friday, but was listed as questionable for Sunday’s game against the Indianapolis Colts. Update 10/9: Kyler Murray did not practice on Thursday, according to Schefter. Update 10/8: Murray, who has been dealing with a foot injury, is not expected to practice on Wednesday with the Cardinals, according to NFL Network Insider Ian Rapoport. Schefter reported that Cardinals head coach Jonathan Gannon said that Murray is taking it “day by day.”
Darius Slayton, WR, New York Giants
Update 10/8: Darius Slayton was out of Thursday’s game against the Eagles with a hamstring injury, according to Schefter.
Ricky Pearsall, WR, San Francisco 49ers
Update 10/10: Pearsall did not practice on Friday. Update 10/9: Pearsall did not practice with the team on Thursday, but worked on individual drills on the side fields. 49ers general manager John Lynch also hinted on Thursday that Pearsall will miss the team’s game against the Tampa Bay Buccaneers. Update 10/8: 49ers head coach Kyle Shanahan said on Wednesday that the team is “not counting on” Ricky Pearsall playing in Week 6.
Miles Sanders, RB, and Trevon Diggs, CB, Dallas Cowboys
Update 10/10: Sanders is being placed on season-ending Injured Reserve by the Cowboys on Friday. Diggs has been listed as questionable for Sunday’s game. Update 10/9: Miles Sanders did not practice on Thursday. Trevon Diggs was a limited participant in Thursday’s practice. Update 10/8: Sanders, who has been dealing with ankle and knee injuries, was listed as a DNP on Wednesday on the Cowboys’ injury report. Diggs, who has been dealing with a knee injury, was a limited participant in Wednesday’s practice.
Brock Bowers, TE, Las Vegas Raiders
Update 10/10: Brock Bowers has been ruled out of Sunday’s game against the Tennessee Titans, according to NFL Network Insider Mike Garafolo. Update 10/9: Bowers did not practice with team on Thursday. Raiders head coach Pete Carroll said Bowers is “day-to-day” at this time. Update 10/8: Brock Bowers did not practice on Wednesday due to his knee injury, according to Schefter.
Chris Godwin and Mike Evans, WRs, Tampa Bay Buccaneers
Update 10/10: Chris Godwin, who has been dealing with a fibula injury, and Mike Evans, who is dealing with a hamstring injury, have been ruled out of Sunday’s game against the 49ers.
Xavier Worthy, WR, Kansas City Chiefs
Update 10/10: Chiefs head coach Andy Reid said Xavier Worthy, who has been dealing with shoulder and ankle injuries, was at practice on Friday and “moved around good.” It’s looking like Worthy will be back this week for Sunday night’s game against the Lions.
Christian Watson, WR, Green Bay Packers
Update 10/10: Christian Watson, who has been dealing with a knee injury and is on Injured Reserve, has been ruled out of Sunday’s game against the Bengals.
Out for the Year
- James Conner, RB, Arizona Cardinals (Foot)
- Malik Nabers, WR, New York Giants (Knee)
- Antonio Gibson, RB, New England Patriots (Knee)
- Spencer Shrader, K, Indianapolis Colts (Knee)
- Tyreek Hill, WR, Miami Dolphins (Knee)
- Trishton Jackson, WR, Arizona Cardinals (Thumb)
- Emory Jones, QB, Atlanta Falcons (Concussion)
- Dayton Wade, WR, Baltimore Ravens (Rib)
- Jonathon Brooks, RB, Carolina Panthers (Knee)
- Deion Hankins, RB, Chicago Bears (Shoulder)
- Cade McDonald, WR, Cleveland Browns (Undisclosed)
- Kye Robichaux, RB, Detroit Lions (Undisclosed)
- Irv Smith, TE, Houston Texans (Ankle)
- Brevin Jordan, TE, Houston Texans (Knee)
- D.J. Montgomery, WR, Indianapolis Colts (Undisclosed)
- Joshua Cephus, WR, Jacksonville Jaguars (Undisclosed)
- Keaontay Ingram, RB, Kansas City Chiefs (Undisclosed)
- Najee Harris, RB, Los Angeles Chargers (Achilles)
- Alexander Mattison, RB, Miami Dolphins (Neck)
- Jalin Conyers, TE, Miami Dolphins (Leg)
- Rondale Moore, WR, Minnesota Vikings (Knee)
- Lan Larison, RB, New England Patriots (Foot)
- Deneric Prince, RB, New England Patriots (Undisclosed)
- Bub Means, WR, New Orleans Saints (Leg)
- Bryce Ford-Wheaton, WR, New York Giants (Achilles)
- Johnny Wilson, WR, Philadelphia Eagles (Knee)
- Donald Parham Jr, TE, Pittsburgh Steelers (Achilles)
- Trent Taylor, WR, San Francisco 49ers (Undisclosed)
- Kenny McIntosh, RB, Seattle Seahawks (Knee)
- Jaden Smith, WR, Tampa Bay Buccaneers (Undisclosed)
- Will Levis, QB, Tennessee Titans (Shoulder)
- Austin Ekeler, RB, Washington Commanders (Achilles)
- Tyree Jackson, TE, Washington Commanders (Undisclosed)