College football picks and predictions against the spread for Week 10

These college football picks and predictions ahead of Week 10 feature some intriguing home favorites and an underdog team that shouldn't be.

The college football season has reached double-digits in the week column as Week 10 is upon us. Midweek MACtion kicks off this week as the most wonderful time of the year is finally here. With that in mind, get in while you can with our first look at the picks and predictions ahead of college football’s Week 10.

College football predictions, picks, and odds for Week 10

Our favorite bets of Week 9 had a rough finish despite starting out incredibly hot. Let’s strike while the iron’s hot. Here are the early lines for all the NCAAF games as of Monday, November 1 at 11:30 AM ET.


  • Ball State @ Akron (+19.5)
  • Eastern Michigan @ Toledo (-9)
  • Miami OH @ Ohio (+7.5)


  • Central Michigan @ Western Michigan (-10)
  • Northern Illinois @ Kent State (-3.5)


  • Georgia State @ Louisiana (-11.5)


  • Virginia Tech @ Boston College (+3.5)
  • Utah @ Stanford (+7)


  • Army @ Air Force (-2.5)
  • Ohio State @ Nebraska (+14.5)
  • Liberty @ Ole Miss (-9)
  • Pittsburgh @ Duke (+21)
  • Wake Forest @ North Carolina (-2.5)
  • Kansas State @ Kansas (+23.5)
  • SMU @ Memphis (+5)
  • Missouri @ Georgia (-38)
  • Louisiana Tech @ UAB (-13.5)
  • Illinois @ Minnesota (-14.5)

Saturday cont’d

  • Georgia Tech @ Miami (FL) (-10)
  • Apalachian State @ Arkansas State (+21)
  • Temple @ East Carolina (-15)
  • California @ Arizona (+11.5)
  • North Texas @ Southern Miss (+5)
  • UL-Monroe @ Texas State (-4)
  • Michigan State @ Purdue (+3)
  • Wisconsin @ Rutgers (+12.5)
  • Tulsa @ Cincinnati (-22.5)
  • Auburn @ Texas A&M (-4.5)

Saturday cont’d

  • Oklahoma State @ West Virginia (+2.5)
  • Baylor @ TCU (+7)
  • Middle Tennessee State @ Western Kentucky (-15)
  • Navy @ Notre Dame (-21)
  • Penn State @ Maryland (+10.5)
  • South Alabama @ Troy (-4)
  • Colorado State @ Wyoming (+3.5)
  • Rice @ Charlotte (-6)
  • Utah State @ New Mexico State (+18.5)
  • NC State @ Florida State (+3)

Saturday cont’d

  • Mississippi State @ Arkansas (-5.5)
  • Tulane @ UCF (-12.5)
  • Coastal Carolina @ Georgia Southern (+19.5)
  • Marshall @ Florida Atlantic (+1)
  • Iowa @ Northwestern (+12)
  • Tennessee @ Kentucky (-1.5)
  • Oregon State @ Colorado (+10.5)
  • Boise State @ Fresno State (-5.5)
  • UNLV @ New Mexico (-2)
  • Old Dominion @ FIU (+3)

Saturday cont’d

  • LSU @ Alabama (-28.5)
  • Indiana @ Michigan (-19.5)
  • Oregon @ Washington (+6.5)
  • Florida @ South Carolina (+18)
  • Texas @ Iowa State (-6.5)
  • Clemson @ Louisville (+4)
  • Houston @ South Florida (+13.5)
  • San Jose State @ Nevada (-10)
  • UTSA @ UTEP (+10.5)
  • USC @ Arizona State (-8)
  • San Diego State @ Hawaii (+7)

Early Week 10 college football picks and predictions

Let’s break down some of my favorite early lines for Week 10, including Georgia State vs. Louisiana, Wake Forest vs. North Carolina, Georgia Tech vs. Miami, and UNLV vs. New Mexico.

Georgia State vs. Louisiana (-11.5)

Time: Thursday, November 4, 7:30 PM ET

The Panthers enter this game riding a three-game win streak. But if you look closely, those three games have come against teams with a combined record of 8-16. They’ve hardly looked like world-beaters against the likes of Texas State and Georgia Southern.

Louisiana, however, has looked like world-beaters. Their offense is humming, and their lone loss this season was to Texas in the season opener. They’ve defeated their last three opponents by a combined 73 points. Lest we forget, there’s also a 1-point squeaker in there against Arkansas State. They’re blowing out teams that they should blow out.

Levi Lewis is completing over 60% of his throws and just set the Louisiana school record for career passing touchdowns. He doesn’t get enough credit, and Louisiana is out to prove they’re the top of the Sun Belt. The rest of the season has winnable games, and as long as they don’t get caught looking ahead, Louisiana should cruise comfortably into the Sun Belt Championship Game.

Wake Forest (+2.5) vs. North Carolina

Time: Saturday, November 6, 12 PM ET

This Wake Forest team is for real and no North Carolina team should surprise them. Even if they have to travel to Chapel Hill, expect the Demon Deacons to look like they belong among the best of the ACC. Wake getting 2.5 points seems out of place even if you give UNC a 3-point swing for home-field advantage.

The Demon Deacons are the better team at every turn and have the better quarterback playing his hottest football to date. Wake hasn’t scored fewer than 35 points all season long and is fresh off a performance against Duke that saw them limit the Blue Devils to just 7 points.

North Carolina gave Notre Dame its all but was outdone by untimely turnovers. They can’t afford those against the Deacs. Wake QB Sam Hartman was just named a Maxwell Award semifinalist thanks in part to a ridiculous 22-3 touchdown-to-interception ratio. He’s ripping off nearly 10 yards per pass attempt while completing over 65% of his throws.

UNC doesn’t have the horses on defense to run with the Deacs. Wake should win outright.

Georgia Tech vs. Miami (FL) (-10)

Time: Saturday, November 6, 12:30 PM ET

The Hurricanes have their quarterback of the future. Tyler Van Dyke lit up the Pittsburgh defense and outplayed the former Heisman Trophy front-runner in Kenny Pickett.

The Miami defense is incredibly young but playing well, all things considered. James Williams is a terrific young safety and looks a lot like a young Kam Chancellor.

Related | College Football Team of the Week: Tyler Van Dyke ushers in a new era for the Miami Hurricanes

The Georgia Tech offense is more than a season away from competing with the likes of this Miami defense, even if the Hurricanes trot out several first-year players.

Van Dyke completed 32-of-42 for 426 yards and 3 touchdowns against Pittsburgh, which have several players at the top of their position rankings in the ACC. Most importantly, Van Dyke was kept clean for the most part, as the Miami offensive line looked much better than they have all season long. If Miami keeps Van Dyke clean, they win big.

UNLV (-2) vs. New Mexico

Time: Saturday, November 6, 7 PM ET

The Rebels are a mere 16 points away from having four wins on the season. They’ve had some horrible luck while unfortunate injuries have taken their toll. Yet, UNLV enters this game against the Lobos as the favorites. And simply put, being the favorites may not be warranted.

Yet, we’re backing the Rebels here. New Mexico just limited Wyoming to 3 points after allowing at least 30 points in each of their last three outings. Call me crazy, but I’m going to call that the anomaly. UNLV QB Cameron Friel has had a rough go at times, mainly because he’s not been able to set his feet and make throws without pressure in his face.

Pressure is not New Mexico’s strong suit, as they’ve recorded only 17 sacks on the season and just 7 in their past three games. UNLV can play loose and free as they fight for their first win. They’ll need at least one bounce to go their way, but they get it done.

Cam Mellor is the Senior Director of the College Football/NFL Draft vertical for Pro Football Network. He is also the co-host of Between the Hashes, a college football and NFL draft podcast. You can find his writing here. Follow him on Twitter @CamMellor


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