Our USF vs. Memphis prediction highlights one of Week 9’s biggest American Conference showdowns, as both teams enter the matchup with identical 6-1 records. No. 18 South Florida makes the trip to Simmons Bank Liberty Stadium to take on a Memphis team eager to bounce back into the Top 25 after falling just short last weekend.
With both teams sitting near the top of the American standings, the stakes for this midseason meeting couldn’t be higher. The result could play a pivotal role in shaping the conference title race and determining which program stays in the hunt for a College Football Playoff spot.
USF vs. Memphis Details
- Date: Oct. 25, 2025
- Game time: 12:00 p.m. ET
- Location: Simmons Bank Liberty Stadium, Memphis, TN
- Predicted Weather at Kick: 66 degrees
- How To Watch: ESPN
USF vs. Memphis Head-to-Head Record
The first meeting between USF and Memphis took place on  Sept.  22,  2001, in Memphis, where the Tigers earned a  17–9  victory. This weekend marks the 14th game in the series between the two programs. According to official records, Memphis leads the all‑time series  9‑4  and has won each of the past four meetings (2019, 2020, 2023, 2024).
The Tigers have consistently performed well at home, while  USF  is determined to end that streak and rewrite the recent narrative. Behind one of the most balanced and explosive offenses in the American Conference this season, the Bulls enter this matchup confident in their ability to flip the momentum and secure a crucial win on the road.
USF vs. Memphis Grades
- USF Bulls (78.2, C+)
- Memphis Tigers (78.8, C+)
- USF Bulls (77.2, C+)
- Memphis Tigers (75.7, C)
- USF Bulls (79.9, C+)
- Memphis Tigers (78.7, C+)
- Byrum Brown, USF Bulls (78.9, C+)
- Brendon Lewis, Memphis Tigers (76.8, C)
- Sam Franklin, USF Bulls (67, D)
- Greg Desrosiers Jr., Memphis Tigers (72, C-)
- Chas Nimrod, USF Bulls (75.9, C)
- Cortez Braham Jr., Memphis Tigers (79.5, C+)
- Jonathan Echols, USF Bulls (76.4, C)
- Christian Ross, Memphis Tigers (72.2, C-)
- Ira Singleton, USF Bulls (70.3, C-)
- Everett Roussaw Jr., Memphis Tigers (73.8, C)
- Traevon Mitchell, USF Bulls (80.7, B-)
- Jalen Bell, Memphis Tigers (76.6, C)
- Mac Harris, USFÂ Bulls (79.8, C+)
- Sam Brumfield, Memphis Tigers (72.7, C-)
- James Chenault, USFÂ Bulls (79.1, C+)
- Jaidyn Denis, Memphis Tigers (82.9, B-)
- Fred Gaskin, USF Bulls (76.5, C)
- Kamari Wilson Memphis Tigers (81.8, B-)
USF vs. Memphis Prediction
USF vs Memphis should be one of Week 9’s most competitive matchups and an entertaining game for fans to watch. While Memphis has the home-field advantage, USF enters the game riding off a four-game winning streak, while the Tigers are looking to bounce back from a loss.
The Bulls have been one of the biggest surprises this season, fueled by standout plays from their dual-threat quarterback, Byrum Brown. Brown has thrown 1,695 passing yards for 16 touchdowns and added 475 rushing yards and six touchdowns in just seven games.
Memphis quarterback Brendon Lewis is equally versatile. Lewis has recorded 1,337 passing yards and eight touchdowns, along with 440 rushing yards with seven touchdowns. His ability to extend plays will be key against USF’s defense, which has thrived on turnovers this season.
Prediction: USF 34, Memphis 31
