Ole Miss vs. Oklahoma Prediction: Can the Sooners Sink the Rebels in All-Ranked SEC Matchup?

Our Ole Miss vs. Oklahoma prediction centers on one of Week 9’s most intriguing SEC matchups, where two top-15 programs battle to stay in the national spotlight. No. 8 Ole Miss (6-1, 3-1 SEC) heads to Norman to take on No. 13 Oklahoma (6-1, 2-1 SEC) in a game loaded with postseason implications.

Ole Miss vs. Oklahoma Details

• Date: Oct. 25, 2025
• Game time: 12:00 p.m. ET
• Location: Gaylord Family – Oklahoma Memorial Stadium, Norman, Okla.
• Predicted Weather at Kick: 63 degrees
• TV Channel: ABC

Ole Miss vs. Oklahoma Head-to-Head Record

The series between Oklahoma and Ole Miss has been brief yet notable in the history of college football. Their first meeting took place at the Independence Bowl on December 31, 1999, where Ole Miss earned a narrow victory. The two programs wouldn’t meet again until October 26, 2024, when the Rebels defeated the Sooners 26-14 in Oxford.

This weekend’s matchup marks their third all-time meeting, and the first time Oklahoma will host Ole Miss at Gaylord Family Oklahoma Memorial Stadium. Before the SEC realignment, the teams had never faced off in regular-season play because Oklahoma was affiliated with the Big 12.

The Sooners’ move to the Southeastern Conference in July 2024 created new opportunities for cross-division rivalries, such as this one. According to Ole Miss’ official record, the Rebels lead the all-time series 2-0, entering Week 9 with an undefeated mark against Oklahoma.

Ole Miss vs. Oklahoma Grades

PFSN College OFFi

• Oklahoma Sooners (76.9, C)
• Ole Miss Rebels  (87.4, B+)

PFSN College DEFi

• Oklahoma Sooners (98.1, A+)
• Ole Miss Rebels  (77.5, C+)

PFSN College OLi

• Oklahoma Sooners (84.8, B)
• Ole Miss Rebels  (76.3, C)

PFSN College QBi

• John Mateer, Oklahoma Sooners (78.5, C+)
• Trinidad Cambliss, Ole Miss Rebels (N/A)

PFSN College RBi

• Tory Blaylock, Oklahoma Sooners (84.2, B-)
• Kewan Lacy, Ole Miss Rebels  (85.5, B)

PFSN College WRi

• Isaiah Sategna III, Oklahoma Sooners (78, C+)
• Harrison Wallace III, Ole Miss Rebels  (78.2, C+)

PFSN College TEi

• Jaren Kanak, Oklahoma Sooners (80.2, B-)
• Dae’Quan Wright, Ole Miss Rebels  (84.8, B)

PFSN College EDGEi

• R Mason Thomas, Oklahoma Sooners (80.5, B-)
• Kam Franklin, Ole Miss Rebels  (77.5, C+)

PFSN College DTi

• David Stone, Oklahoma Sooners (85.9, B)
• Will Echoles, Ole Miss Rebels  (84.5, B)

PFSN College LBi

• Sammy Omosigho, Oklahoma Sooners (70.9, C-)
• TJ Dottery, Ole Miss Rebels  (74.7, C)

PFSN College CBi

• Courtland Guillory, Oklahoma Sooners (78.4, C+)
• Antonio Kite, Ole Miss Rebels  (80.9, B-)

PFSN College SAFi

• Wydett Williams Jr., Oklahoma Sooners (88.3, B+)
• Peyton Bowen, Ole Miss Rebels  (80.3, B-)

Ole Miss vs. Oklahoma Prediction

Oklahoma has the home-field advantage, and its defense has made plays and really stood out this season. The Sooners lead the nation in total defense and top the PFSN DEFi ratings. Head coach Brent Venables’ background as a defensive coordinator has really has clearly made an impact on the unit.

Ole Miss, on the other hand, is coming off its first loss of the season against Georgia, but its offense remains explosive and should be ready for Saturday’s matchup.

Head coach Lane Kiffin, a former offensive coordinator, has built a solid defensive line around Cambliss. The Rebels’ offense has thrived this season when Cambliss connects with wide receivers Harrison Wallace III, Deuce Alexander, tight end Dae’Quan Wright, and running back Kewan Lacy.

Both teams have clear strengths: Oklahoma’s talented defense against Ole Miss’ fast-paced offense. With their momentum from last week’s win and home-field advantage on their side, the Sooners are positioned to come out on top in a close win.

Prediction: Oklahoma 24, Ole Miss 21