As the NFL heads into Week 13, with an early start on Thanksgiving Day, several teams are dealing with some major injury questions. The 2025 NFL season is currently in November, so teams are facing a crunch time for maintaining healthy bodies.
For NFL fans and fantasy managers, the injury list is critical for understanding who might be out or limited in the upcoming games. Here’s a breakdown of the notable injuries and what you need to know about them heading in.
Omarion Hampton, RB, Los Angeles Chargers
Update 11/26: On Wednesday night, ESPN NFL Insider Adam Schefter posted an update on X regarding Chargers running back Omarion Hampton.
Chargers RB Omarion Hampton revealed Wednesday that he has been dealing with a left ankle fracture sustained in Week 5 against the Commanders. The undisclosed injury landed Hampton on injured reserve, and he hasn’t played since.
Story via @krisrhim1:https://t.co/hC4FxDicCG
— Adam Schefter (@AdamSchefter) November 27, 2025
According to Schefter’s report, Hampton “revealed Wednesday that he has been dealing with a left ankle fracture sustained in Week 5 against the Commanders. The undisclosed injury landed Hampton on injured reserve, and he hasn’t played since.”
Update 11/25: On Tuesday, Chargers head coach Jim Harbaugh said that the practice window is being opened for running back Omarion Hampton, who has not played since Week 5 due to an ankle injury, according to ESPN NFL Insider Adam Schefter.
Chargers HC Jim Harbaugh announced the practice window is being opened for RB Omarion Hampton, who has not played since week five against Washington due to an ankle injury.
— Adam Schefter (@AdamSchefter) November 25, 2025
Hampton, who has been on Injured Reserve since suffering an ankle injury back in Week 5, is due back on the practice field in a full-go situation this week.
The Chargers are coming off their bye week, so Hampton got even more time to recover from his injury. So far this season, Hampton has 66 carries for 314 yards and two touchdowns.
According to the PFSN NFL RB Impact metrics, Hampton has an impact score of 72.1 and grades out to a C-.
Joe Burrow, QB, Tee Higgins, WR, and Trey Hendrickson, DE, Cincinnati Bengals
Update 11/26: Bengals fans got an early Thanksgiving Day gift on Wednesday with news that starting quarterback Joe Burrow would be returning to the team’s starting lineup. The Bengals even put out a special post on X announcing Burrow’s return.
He’s back. pic.twitter.com/WRUmF3tRlZ
— Cincinnati Bengals (@Bengals) November 26, 2025
Burrow was placed on the Reserve/Injured list on Sept. 16 with a toe injury. He was designated for return from that list and returned to practice on Nov. 10.
Meanwhile wide receiver Tee Higgins, who suffered a concussion on Sunday, has been ruled out of Cincinnati’s game on Thanksgiving Day against the Baltimore Ravens.
Zac Taylor speaks to the media. https://t.co/xInLr6RoY9
— Cincinnati Bengals (@Bengals) November 24, 2025
Bengals head coach Zac Taylor revealed the news about Higgins in his Monday press conference. Also, Taylor said that defensive end Trey Hendrickson, who has been dealing with a hip injury, will also be out against the Ravens.
According to the PFSN NFL WR Impact metrics, Higgins has an impact score of 77.2 and grades out to a C+.
Jayden Daniels, QB, and Terry McLaurin, WR, Washington Commanders
Update 11/28: On Friday, Commanders head coach Dan Quinn said quarterback Jayden Daniels would not play on Sunday night against the Denver Broncos. Wide receiver Terry McLaurin, though, is expected to take the field.
Isiah Pacheco, RB, Kansas City Chiefs
Update 11/25: On Tuesday, Chiefs head coach Andy Reid announced that running back Isiah Pacheco, who has been out with a knee injury, will return to action on Thanksgiving Day when the Chiefs play the Dallas Cowboys at AT&T Stadium in Arlington, Texas.
Chiefs coach Andy Reid told reporters that RB Isiah Pacheco (knee) will return from his knee injury and play against the Cowboys on Thursday.
— Tom Pelissero (@TomPelissero) November 25, 2025
According to the PFSN NFL RB Impact metrics, Pacheco has an impact score of 71.5 and grades out to a C-. In eight games in the 2025 NFL season, Pacheco has 78 carries for 329 yards and one touchdown.
Drake London, WR, Atlanta Falcons
Update 11/26: Falcons head coach Raheem Morris on Wednesday said it looked “doubtful” that wide receiver Drake London would be ready in time for Atlanta’s game against the New York Jets. NFL Network Insider Ian Rapoport reported the update in a post on X on Wednesday.
According to the PFSN NFL WR Impact metrics, London has an impact score of 83.5 and grades out to a B.
Josh Allen, QB, and Dalton Kincaid, TE, Buffalo Bills
Update 11/28: Bills tight end Dalton Kincaid is listed as questionable for Sunday’s game against the Pittsburgh Steelers, according to Schefter. Other players who have been ruled out for the Bills include starting tackles Spencer Brown and Dion Dawkins, along with linebacker Terrel Bernard and wide receiver Curtis Samuel.
Update 11/26: On Wednesday, Bills quarterback was listed on the team’s injury report with a right elbow injury, according to NFL Network Insider Tom Pelissero. Allen was listed, though, as a full participant in the team’s practice on Wednesday.
Trey Benson, Bam Knight, Emari Demercado, RBs, and Marvin Harrison, WR, Arizona Cardinals
Update 11/28: On Friday, Cardinals running back Trey Benson was ruled out of Sunday’s game against the Tampa Bay Buccaneers, according to ESPN NFL Insider Adam Schefter. Also ruled out were fellow running back Emari Demercado, guard Will Hernandez and defensive tackle Walter Nolen. Additionally, running back Bam Knight and wide receiver Marvin Harrison are listed as questionable.
Benson has been out of action and on Injured Reserve with a knee injury. But Benson returned to the Cardinals’ practice field last week and was a healthy scratch ahead of Arizona’s game with the Jacksonville Jaguars on Sunday.
Baker Mayfield, QB, and Bucky Irving, RB, Tampa Bay Buccaneers
Update 11/28: On Friday, according to Buccaneers reporter Rick Stroud of the Tampa Bay Times, Tampa Bay head coach Todd Bowles said that quarterback Baker Mayfield “looked good today” and is trending toward starting on Sunday against the Arizona Cardinals. As for running back Bucky Irving, he was not among Buccaneers players ruled out of Sunday’s game on Friday.
Update 11/26: On Wednesday, Buccaneers head coach Todd Bowles said that quarterback Teddy Bridgewater would be getting most of the starters’ reps this week while quarterback Baker Mayfield remains a possible starter on Sunday against the Arizona Cardinals, NFL Network Insider Mike Garafolo reported.
Mayfield himself spoke to reporters on Wednesday at the Buccaneers’ practice facility about the pain in his left, non-throwing shoulder.
When asked about the pain in his injured left non-throwing shoulder, Baker Mayfield said, “It’s there” but it’s “decreasing for sure.” The MRI revealed that it’s stable structurally but it’s a pain tolerance issue. “If it’s gonna hinder how I play, then I probably won’t go. But I… pic.twitter.com/wUw3XsMdMV
— JennaLaineESPN (@JennaLaineESPN) November 26, 2025
“It’s there” but it’s “decreasing for sure,” Mayfield said. ESPN NFL Buccaneers reporter Jenna Laine added that Mayfield’s MRI revealed that his left shoulder is stable structurally but it’s a pain tolerance issue. “If it’s gonna hinder how I play, then I probably won’t go,” Mayfield said. “But I won’t know that until later in the week of getting practice reps and see how that goes.”
Update 11/25: Mayfield, who suffered a sprained left shoulder on Sunday Night Football, has a low-grade sprain, according to sources after Mayfield had an MRI, NFL Network Insider Ian Rapoport reported on Monday. It looks like, at this time, that Mayfield could start next week.
Meanwhile, all signs point toward Buccaneers running back Bucky Irving to return this week. Buccaneers head coach Todd Bowles offered an update on Irving’s condition on Monday, indicating that Irving will be on the team’s practice field this week ahead of Sunday’s game.
Bowles said today that Bucky Irving will continue to practice all week and if he’s good he’ll play Sunday. He had said Friday that was the plan. https://t.co/TUpJPfoj0y
— Greg Auman (@gregauman) November 24, 2025
Last week, Bowles said this was the plan involving Irving at the time. So, Buccaneers fans can look forward to seeing Irving in the backfield. Now, the question will be who starts at quarterback after Buccaneers starter Baker Mayfield left Sunday night’s game with an injury.
According to the PFSN NFL RB Impact metrics, Irving has an impact score of 61.4 and grades out to a D-.
C.J. Stroud, QB, and Jalen Pitre, S, Houston Texans
Update 11/28: On Friday, Texans head coach DeMeco Ryans said that quarterback C.J. Stroud and safety Jalen Pitre, who have been out with concussions, will start on Sunday against the Indianapolis Colts, according to Dianna Russini of The Athletic.
Daniel Jones, QB, Sauce Gardner, CB, and Tyler Warren, TE, Indianapolis Colts
Update 11/29: On Saturday, the Colts listed tight end Tyler Warren, who is dealing with an illness, as questionable for Sunday’s game against the Houston Texans.
Update 11/28: On Friday, Colts head coach Shane Steichen said that quarterback Daniel Jones, who suffered a fracture in his fibula, is good to go on Sunday, according to NFL Network Insider Ian Rapoport.
Update 11/26: Colts quarterback Daniel Jones, who is dealing with a fibula injury, and cornerback Sauce Gardner, who is dealing with a back injury, were both listed as limited participants at practice on the Colts’ estimated injury report, according to Pelissero.
DeVonta Smith, WR, Philadelphia Eagles
Update 11.26: On Wednesday, Eagles wide receiver DeVonta Smith did not practice with the team due to shoulder-chest-illness issues, according to ESPN NFL Insider Adam Schefter.
Matthew Golden, WR, and Josh Jacobs, RB, Green Bay Packers
Update 11/26: On Wednesday, Packers wide receiver Matthew Golden was listed as questionable for the Thanksgiving Day game against the Detroit Lions at Ford Field. Meanwhile, Packers running back Josh Jacobs does not have an injury designation and appears to be good to go on Thursday, according to ESPN NFL Insider Adam Schefter.
JJ McCarthy, QB, Minnesota Vikings
Update 11/28: On Friday, Vikings quarterback JJ McCarthy was ruled out of Sunday’s game, according to Albert Breer, Senior NFL Reporter of The MMBQ. ESPN NFL Insider Adam Schefter reported that McCarthy is still in concussion protocol at this time. Max Brosner will get the start at quarterback for Minnesota.
Update 11/26: On Wednesday, the Vikings said that quarterback JJ McCarthy was going to participate in individual drills at the Vikings’ practice. McCarthy would not be involved in any team drills, according to ESPN NFL Insider Adam Schefter. Quarterback Max Brosmer was set to take all of the first-team reps in Wednesday’s practice.
Rashee Rice, WR, Kansas City Chiefs
Update 11/26: On Wednesday, Chiefs wide receiver Rashee Rice, who has been sidelined with a hamstring injury, was listed by the Chiefs as a full participant at practice for the past two days, according to Schefter.
After being listed as a limited participant at practice earlier in the week due to a hamstring injury, Chiefs WR Rashee Rice was listed as a full participant the past two days and is good to go Thursday vs. Dallas. https://t.co/6M8lTwksOt
— Adam Schefter (@AdamSchefter) November 26, 2025
It appears that Rice will be ready to go for the Chiefs’ game against the Dallas Cowboys on Thursday. Additionally, the Chiefs ruled out guard Trey Smith and tight end Noah Gray from the Thanksgiving Day contest.
Alvin Kamara and Devin Neal, RBs, and Chris Olave, WR, New Orleans Saints
Update 11/28: On Friday, Saints running back Alvin Kamara was ruled out of Sunday’s game against the Miami Dolphins, according to NFL Network Insider Tom Pelissero. But Saints head coach Kellen Moore said that Kamara, who suffered a knee strain last Sunday, will not be placed on Injured Reserve. Additionally, wide receiver Chris Olave, who is dealing with a back injury, is listed as questionable. Running back Devin Neal, who has been dealing with an ankle injury, is “good to go.”
Saints running back Alvin Kamara reportedly suffered a knee strain in Sunday’s game against the Atlanta Falcons, according to NFL Network Insider Ian Rapoport.
Kamara was to undergo an MRI to determine the full extent of his injury. Yet the hope is that he could have avoided suffering a significant injury. Should Kamara be out for some length of time, then Devin Neal could see more time as the Saints’ top running back.
According to the PFSN NFL RB Impact metrics, Kamara has an impact score of 73.7 and grades out to a C.
Jaxson Dart, QB, New York Giants
Update 11/28: On Friday, Giants head coach Mike Kafka reported that quarterback Jaxson Dart will take the field on Sunday against the New England Patriots.
Update 11/26: On Wednesday, Giants rookie quarterback Jaxson Dart was a full participant at the team’s practice, the Giants reported.
Giants said QB Jaxon Dart was a full participant in today’s practice, giving him a chance to make his first start on Monday Night Football vs. the Patriots. pic.twitter.com/fDcZHJzQrA
— Adam Schefter (@AdamSchefter) November 26, 2025
This gives Dart a chance to make his first start on Monday Night Football when the Giants play the New England Patriots, according to ESPN NFL Insider Adam Schefter.
Aaron Rodgers, QB, Pittsburgh Steelers
Update 11/28: On Friday, Steelers quarterback Aaron Rodgers was asked if he’s going to start on Sunday against the Buffalo Bills. Rodgers said, “All systems go.” Steelers reporter Chris Adamski of the Pittsburgh Tribune-Review had the report on Friday.
Update 11/26: Rodgers was not seen on the Steelers’ practice field during the open media time on Wednesday. Quarterbacks Mason Rudolph and Will Howard were shown going through reps, according to ESPN Steelers reporter Brooke Pryor.
Update 11/25: Steelers head coach Mike Tomlin said on Tuesday that he has “great optimism” about the trajectory of Rodgers, who missed last Sunday’s game with a fractured bone in his wrist, coming back on Sunday against the Buffalo Bills, NFL Network Insider Ian Rapoport reported.
Darren Waller, TE, Miami Dolphins
Update 11/28: On Friday, Dolphins head coach Mike McDaniel said that tight end Darren Waller, who has been dealing with a pectoral injury, could be activated from Injured Reserve ahead of Sunday’s game against the New Orleans Saints. McDaniel also said the same about tackle Austin Jackson, who has been dealing with a toe injury.
Lamar Jackson, QB, Kyle Hamilton, S, and Rashod Bateman, WR, Baltimore Ravens
Update 11/26: Ravens quarterback Lamar Jackson was a full participant in Wednesday’s practice and will be good to go for Thursday night’s game against the Baltimore Ravens, NFL Network Insider Mike Garafolo reported.
#Ravens S Kyle Hamilton a full go today and no game status. Same with QB Lamar Jackson and WR Rashod Bateman, who was upgraded to full today. All set to go tomorrow. pic.twitter.com/y2jI15Evrr
— Mike Garafolo (@MikeGarafolo) November 26, 2025
Also listed as full-go players for Thursday night were safety Kyle Hamilton and wide receiver Rashod Bateman.
Update 11/25: On Tuesday, Ravens quarterback Lamar Jackson returned to the Ravens’ practice field after taking a day off on Monday, NFL Network Insider Mike Garafolo reported.
Jackson missed Monday’s walkthrough due to a toe injury, but showed no signs of it bothering him when running onto the practice field on Tuesday.
George Pickens, WR, Dallas Cowboys
Update 11/25: On Tuesday, Cowboys wide receiver George Pickens, who has been dealing with knee and calf injuries, was on the Dallas practice field.
Cowboys WR George Pickens (knee/calf) is practicing today pic.twitter.com/pYbAqH47DS
— Jon Machota (@jonmachota) November 25, 2025
Pickens is working his way back into playing condition at this time.
Marcus Davenport, DE, Detroit Lions
Update 11/25: On Tuesday, Lions head coach Dan Campbell said that defensive end Marcus Davenport, who has been out with a right pec injury, and his status for the Thanksgiving Day home game at Ford Field against the Green Bay Packers is to be determined.
Coach Campbell on Marcus Davenport working his way back from injury pic.twitter.com/4rqpAFRIS4
— Detroit Lions (@Lions) November 25, 2025
Campbell made additional comments on Tuesday, saying that safety Kerby Joseph will not play on Thursday.
Ashton Dulin, WR, Indianapolis Colts
Update 11/25: On Tuesday, the Colts placed wide receiver Ashton Dulin on Injured Reserve.
we have placed WR Ashton Dulin on IR and have signed S George Odum to the 53-man roster.
we have also signed CB Cameron Mitchell to the practice squad. pic.twitter.com/3GRM1fCxAp
— Indianapolis Colts (@Colts) November 25, 2025
Dulin has been dealing with a hamstring injury.
Out for the Year
- James Conner, RB, Arizona Cardinals (Foot)
- Joe Mixon, RB, Houston Texans (Foot)
- Chandler Martin, LB, Baltimore Ravens (Knee)
- Michael Penix Jr., QB, Atlanta Falcons (ACL)
- Miles Sanders, RB, Dallas Cowboys (Ankle/Knee)
- Cam Skattebo, RB, New York Giants (Ankle)
- Travis Hunter, WR-CB, Jacksonville Jaguars (Knee)
- Malik Nabers, WR, New York Giants (Knee)
- Antonio Gibson, RB, New England Patriots (Knee)
- Carson Wentz, QB, Minnesota Vikings (Non-throwing shoulder)
- Spencer Shrader, K, Indianapolis Colts (Knee)
- Patrick Jones II, OLB, Carolina Panthers (Back)
- Tyreek Hill, WR, Miami Dolphins (Knee)
- Trishton Jackson, WR, Arizona Cardinals (Thumb)
- Emory Jones, QB, Atlanta Falcons (Concussion)
- Dayton Wade, WR, Baltimore Ravens (Rib)
- Jonathon Brooks, RB, Carolina Panthers (Knee)
- Deion Hankins, RB, Chicago Bears (Shoulder)
- Cade McDonald, WR, Cleveland Browns (Undisclosed)
- Kye Robichaux, RB, Detroit Lions (Undisclosed)
- Irv Smith, TE, Houston Texans (Ankle)
- Brevin Jordan, TE, Houston Texans (Knee)
- D.J. Montgomery, WR, Indianapolis Colts (Undisclosed)
- Joshua Cephus, WR, Jacksonville Jaguars (Undisclosed)
- Keaontay Ingram, RB, Kansas City Chiefs (Undisclosed)
- Najee Harris, RB, Los Angeles Chargers (Achilles)
- Alexander Mattison, RB, Miami Dolphins (Neck)
- Jalin Conyers, TE, Miami Dolphins (Leg)
- Rondale Moore, WR, Minnesota Vikings (Knee)
- Lan Larison, RB, New England Patriots (Foot)
- Deneric Prince, RB, New England Patriots (Undisclosed)
- Bub Means, WR, New Orleans Saints (Leg)
- Bryce Ford-Wheaton, WR, New York Giants (Achilles)
- Johnny Wilson, WR, Philadelphia Eagles (Knee)
- Donald Parham Jr, TE, Pittsburgh Steelers (Achilles)
- Trent Taylor, WR, San Francisco 49ers (Undisclosed)
- Kenny McIntosh, RB, Seattle Seahawks (Knee)
- Jaden Smith, WR, Tampa Bay Buccaneers (Undisclosed)
- Will Levis, QB, Tennessee Titans (Shoulder)
- Austin Ekeler, RB, Washington Commanders (Achilles)
- Tyree Jackson, TE, Washington Commanders (Undisclosed)
