San Francisco 49ers Betting Lines: Preview, Odds, Spreads, Win Total, and More

As you prepare to make your bets for the 2023 NFL season, here is a San Francisco 49ers betting preview with their futures odds, best bets, and more.

After two consecutive losses in the NFC Championship Game, the San Francisco 49ers are looking to make it back to the Super Bowl this season and have the fourth-shortest odds in the NFL. In the NFC, only the Philadelphia Eagles are ahead of San Francisco as favorites to win the conference. The 49ers have had tremendous success under head coach Kyle Shanahan, but they’ve fallen just short of bringing the Lombardi Trophy back to the Bay Area. Is this the year?

Want to bet on the 49ers this season? Take advantage of one of these sportsbook offers below.

[tallysight url=””]

San Francisco 49ers Futures Odds

Super Bowl Odds: +1000

Think the 49ers will win the Super Bowl? Place your Super Bowl wager directly on DraftKings Sportsbook using the widget below.

[tallysight url=”″]

NFC Odds: +400

NFC West Odds: -160

Win Total: 10.5 (Over -145/Under +125)

To Make/Miss the Playoffs: -450/+360

San Francisco 49ers Offense

Despite his elbow injury in the NFC Championship Game, Brock Purdy has been a full-go in training camp. The 2022 NFL Draft’s Mr. Irrelevant was a revelation for the 49ers in the latter half of last season, going 6-0 in the regular season with Purdy as the starting QB.

Having a play-caller like Kyle Shanahan in an offense with weapons such as Christian McCaffrey, George Kittle, Deebo Samuel, and Brandon Aiyuk certainly helped ease the transition.

After the McCaffrey trade last season, the 49ers’ offense ranked second in EPA per play, trailing only the Kansas City Chiefs. Going into this season, San Francisco’s offense has largely the same personnel from a year ago, with OT Mike McGlinchey being a notable exception.

Besides that, this dynamic offense has its set of playmakers intact, which is arguably the most talented group on a single team in the NFL. If Purdy can carry over his magic from last season and his supporting cast stays healthy, the sky is the limit for this offense.

San Francisco 49ers Defense

This was the strength of this team a year ago, leading the NFL in points allowed per game. And yet, the rich got richer this offseason.

The 49ers signed DT Javon Hargrave away from the Eagles, who had 11 sacks last season, further strengthening their defensive line. San Fran’s unit is led by Bosa, the reigning Defensive Player of the Year, who is coming off an 18.5-sack season.

Meanwhile, DC Demeco Ryans leaving to take the Houston Texans’ head coaching job was a big loss for this unit. Incoming defensive coordinator Steve Wilks will have big shoes to fill.

One Betting Trend To Know

The 49ers were 10-5 against the spread last season as favorites, which was second best only behind the Cincinnati Bengals.

From PFN Fantasy & Betting Analyst Kyle Soppe using Inside Edge

Best Bet for the 49ers in 2023

Wingo: One thing we know about San Francisco heading into 2023 is that the team built around the QB is as good as it gets. What we DON’T know is who that QB will be. But does it really matter?

Last season, many people thought that when both Trey Lance and Jimmy G got hurt, the Niners’ season was over. Instead, with Mr. Irrelevant leading the way, San Francisco made it all the way to the NFC Championship Game.

The only concern for SF is when a deal will get done for Bosa, who’s more than happy to eat a $30k fine a day to wait for the massive payday coming his way. This is a Niners team built to win in a division that has several question marks.

The win total for the season is at 10.5. The 49ers have won at least 10 games in three of the last four seasons. Barring another epic injury run at QB, I like the over for San Francisco, who head into the season as one of the top two teams in the NFC.

Over 10.5 wins

Want to tail Trey’s best bet? Place your bet on the widget below!

[tallysight url=”″]

All the NFL betting odds at a moment’s notice — visit our Betting Lines page, bookmark now, and always get the best line and bang for your buck. Our FREE Parlay Calculator and Betting Odds Calculator are also available for your betting process!

Listen to the PFN Betting Podcast

Listen to the PFN Betting Podcast! Click the embedded player below to listen, or you can find the PFN Betting Podcast on iTunes, Spotify, and all major podcast platforms. Be sure to subscribe and leave us a five-star review!

Related Articles