NFL Week 15 Predictions and Picks Against the Spread From Betting Experts: Should You Back Tommy DeVito, Joe Flacco, and Zach Wilson?

What are our experts' NFL Week 15 predictions for the remaining 12 games in an exciting week of action that could help shape the postseason?

Sunday brings us a loaded slate of NFL action and plenty of opportunities for betting with 11 games before a 12th on Monday. Ahead of the majority of the Week 15 action, let’s examine the current lines for the remaining game and see our experts’ predictions and picks against the spread.


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NFL Week 15 Predictions and Picks Against the Spread

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Tampa Bay Buccaneers vs. Green Bay Packers Predictions

  • Spread
    Packers -3.5
  • Moneyline
    Buccaneers +155, Packers -185
  • Total
    42.5

Blewis: We’ve seen how bad this Buccaneers’ pass defense has been in recent weeks, as they even allowed Desmond Ridder to throw for 347 yards. With how Jordan Love has been playing recently, he should have a field day against this defense at home. Against non-divisional opponents this season, the Buccaneers are 1-5 on the road.

Pick: Packers -3.5

New York Giants vs. New Orleans Saints Predictions

  • Spread
    Saints -5.5
  • Moneyline
    Giants +200, Saints -240
  • Total
    39.5

Bearman: The Saints really shouldn’t be a six-point favorite over anyone. Yes, they won by three touchdowns last week, but that was against the one-win Panthers. I’m not yet buying the Giants’ playoff run, but the Tommy DeVito mania is real. With the way the Giants are playing, six points is too much not to take here.

Pick: Giants +6

Atlanta Falcons vs. Carolina Panthers Predictions

  • Spread
    Falcons -3
  • Moneyline
    Falcons -155, Panthers +135
  • Total
    33.5

Blewis: I’m probably the only person in America who is betting on the Panthers for the third week in a row. With how poorly Ridder has played on the road this season, it seems like a good opportunity to fade him and the Falcons giving three points in Carolina.

MORE: PFN’s FREE NFL Playoff Predictor

The Panthers, with Jaycee Horn back in the lineup, have a better defense than the unit the Falcons put up 25 points against on Sunday at home.

Pick: Panthers +3

Houston Texans vs. Tennessee Titans Predictions

  • Spread
    Titans -3.5
  • Moneyline
    Texans +155, Titans -185
  • Total
    36.5

Blewis: The look-ahead line for this was Texans -3.5, but now C.J. Stroud is in concussion protocol. The five-point swing illustrates how valuable Stroud is to this team, and even before Stroud’s injury, the Texans were starting to get extremely banged up on offense.

I’m not sure Case Keenum can attack this weak Titans pass defense, and I have little faith in the Texans’ running game in this matchup either.

Pick: Under 37.5

New York Jets vs. Miami Dolphins Predictions

  • Spread
    Dolphins -9.0
  • Moneyline
    Jets +380, Dolphins -500
  • Total
    37.5

Blewis: Zach Wilson had maybe the best game of his career on Sunday, as he threw for over 300 yards and two touchdowns in the Jets’ 30-6 win over the Houston Texans. But let’s not let this one-game sample size change our perception of Wilson.

While the Dolphins did have an embarrassing loss on Monday Night Football, they were without Tyreek Hill for nearly half of the game. If he’s a full go for this week, I like their chances of bouncing back in convincing fashion.

Pick: Dolphins -8.5

Chicago Bears vs. Cleveland Browns Predictions

  • Spread
    Browns -3
  • Moneyline
    Bears +130, Browns -150
  • Total
    37.5

Blewis: The Bears’ defense might be the most improved unit of the season, and they’re coming off an impressive performance in their 28-13 win over the Lions, in which Chicago held Detroit to just 267 total yards. This should be a much bigger test for Joe Flacco, who has exceeded everyone’s expectations in two games as the Browns’ starting quarterback.

I’m going to continue to ride with the Bears here, who have ascended from not being one of the worst five teams in the league anymore.

Pick: Bears +3.5

Kansas City Chiefs vs. New England Patriots Predictions

  • Spread
    Chiefs -8.0
  • Moneyline
    Chiefs -450, Patriots +360
  • Total
    37.5

Bearman: Recency bias would say to take the points with the home team coming off their best game of the season on a long week of rest. Nah. This is a great get-right spot for the Chiefs, who all of a sudden find themselves in a battle with the Broncos to win the division. It’s not my favorite pick, but the Chiefs figure it out.

Pick: Chiefs -7.5

Washington Commanders vs. Los Angeles Rams Predictions

  • Spread
    Rams -6.5
  • Moneyline
    Commanders +250, Rams -300
  • Total
    50.5

Bearman: The Commanders are as good as done for 2023, and it won’t be surprising to see the new owner clean house two minutes after the season ends. You couldn’t see any fight in Washington the last time we saw them play, getting blown out by the Dolphins at home.

The Rams are very much alive in the NFC and should have beaten the Ravens in Baltimore last week. They are a team to keep an eye on down the stretch and should win this one easily.

Pick: Rams -6.5 (best bet)

San Francisco 49ers vs. Arizona Cardinals Predictions

  • Spread
    49ers -12
  • Moneyline
    49ers -700, Cardinals +505
  • Total
    48.5

Blewis: Once again, the 49ers’ offense looked unstoppable on Sunday, as they put up 527 yards of offense in their 28-16 win over the Seahawks. It takes a lot of guts to want to fade them at the moment, and even as 14-point road favorites against a division rival, I can’t recommend picking against them.

Pick: 49ers -13.5

Dallas Cowboys vs. Buffalo Bills Predictions

  • Spread
    Bills -2.5
  • Moneyline
    Cowboys +115, Bills -135
  • Total
    49.5

Blewis: The narrative that the Cowboys can’t beat good teams is dead, as they dominated the Eagles in a 33-13 win on Sunday Night Football. The question now is if they can pull it off on the road against a really good Bills team.

MORE: Cowboys vs. Bills Player Prop Bets

I picked the Bills on Sunday to beat the Chiefs, and I think this is the beginning of a late-season run for them. Even at 7-6, you could still argue they’re one of the five scariest teams in the NFL, and this game will be the Cowboys’ biggest test in a long time.

Pick: Bills -1.5

Baltimore Ravens vs. Jacksonville Jaguars Predictions

  • Spread
    Ravens -3.5
  • Moneyline
    Ravens -175, Jaguars +150
  • Total
    42.5

Bearman: With Trevor Lawrence banged up and injuries all over the place, the Jags are not the same team that was on the cusp of controlling their own destiny in the AFC. Now, they host arguably the best team in the AFC: the Ravens.

Pick: Ravens -3

Philadelphia Eagles vs. Seattle Seahawks Predictions

  • Spread
    Eagles -3
  • Moneyline
    Eagles -165, Seahawks +140
  • Total
    47.5

Bearman: The Eagles team you saw in Weeks 13-14 is not the same one you saw in the first 12 weeks of the season. There were a few early games they should not have won, but they didn’t come close to playing as bad as they did in “big boy” games vs. the Niners and Cowboys. The defense looks tired and horrible, while the offense couldn’t generate anything last week.

A little nugget a former colleague at ESPN gave me: Underdogs are 6-0 straight up over the last five weeks in MNF games, including two big underdogs last week in the Giants and Titans. That’s tied for the longest streak of dogs winning outright on MNF since the first six weeks of the 1985 season. Fly, Seahawks, fly.

Pick: Seahawks +4

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