NFL Week 5 Odds and Betting Trends Against the Spread: Trevor Lawrence and Josh Allen in London and More

The NFL Week 5 odds feature more than a few interesting lines with who is favored. What teams can you trust now that we have four weeks of data?

Now that we are a month into the season, things are starting to take shape. The NFL Week 5 odds suggest that we have some powerhouse road teams that may not be as dominant as the general public believes. Do you agree?

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NFL Week 5 Odds and Betting Trends

All odds are from DraftKings Sportsbook and trends from Inside Edge.

Chicago Bears vs. Washington Commanders Odds

  • Spread
    Commanders -6.5
  • Moneyline
    Bears +235, Commanders -290
  • Total
    44.5

The Chicago Bears are a league-worst 5-14 ATS on the road since the beginning of 2021.

Unders have cashed in 15 of the Washington Commanders’ past 19 home games.

Jacksonville Jaguars vs. Buffalo Bills Odds (London)

  • Spread
    Bills -5.5
  • Moneyline
    Jaguars +200, Bills -245
  • Total
    48.5

The Jacksonville Jaguars have covered just three of their past 10 games against top-10 passing offenses.

MORE: Early NFL Week 5 Predictions and Picks Against the Spread

Are you still buying the Jags as a top-10 pass offense of their own? The Buffalo Bills are 1-4 ATS against such teams since the beginning of last season.

Houston Texans vs. Atlanta Falcons Odds

  • Spread
    Falcons -2.5
  • Moneyline
    Texans +110, Falcons -130
  • Total
    41

Unders are 12-7 in Houston Texans road games over the past 2+ seasons.

Only the New Orleans Saints have been a worse ATS team at home since 2021 than the Atlanta Falcons (6-12).

Carolina Panthers vs. Detroit Lions Odds

  • Spread
    Lions -9.5
  • Moneyline
    Panthers +330, Lions -425
  • Total
    44.5

The Carolina Panthers have lost 11 of 12 games vs. top-10 rush offenses since the beginning of 2021, the worst in the league.

The Detroit Lions have covered eight of their past 11 home games and six of their past eight when favored.

Tennessee Titans vs. Indianapolis Colts Odds

  • Spread
    Colts -1
  • Moneyline
    Titans -102, Colts -118
  • Total
    42.5

Only the Saints and New York Giants have cashed under tickets at a higher rate since 2021 than the Tennessee Titans (63%).

The Indianapolis Colts are 1-5-1 outright when favored since the beginning of last season.

New York Giants vs. Miami Dolphins Odds

  • Spread
    Dolphins -11
  • Moneyline
    Giants +425, Dolphins -575
  • Total
    49.5

Since 2021, 14 times have the Giants played a top-10 offense and 14 times they’ve lost.

Since 2021, the Miami Dolphins are the second-worst ATS team when following a loss (5-11).

New Orleans Saints vs. New England Patriots Odds

  • Spread
    Patriots -1.5
  • Moneyline
    Saints +102, Patriots -122
  • Total
    40.5

Unders are 10-1 over the past 2+ seasons when the Saints play a top-10 defense.

The New England Patriots have won eight of their past nine games outright when favored.

Baltimore Ravens vs. Pittsburgh Steelers Odds

  • Spread
    Ravens -4
  • Moneyline
    Ravens -198, Steelers +164
  • Total
    38.5

Under tickets are cashing at a 73% clip since 2021 when the Baltimore Ravens are favored.

Unders are 12-7 in Pittsburgh Steelers home games since 2021.

Philadelphia Eagles vs. Los Angeles Rams Odds

  • Spread
    Eagles -4
  • Moneyline
    Eagles -218, Rams +180
  • Total
    50.5

Since the beginning of last season, only the Bears have seen a higher percentage of their games go over the total than the Philadelphia Eagles (61.9%).

MORE: Rams Only Unbeaten Team Against the Spread and More

The Los Angeles Rams have failed to cover eight of their past 11 games against top-10 defenses.

Cincinnati Bengals vs. Arizona Cardinals Odds

  • Spread
    Bengals -3
  • Moneyline
    Bengals -166, Cardinals +140
  • Total
    44,5

The Cincinnati Bengals have generally been great ATS since 2021, but over that stretch, they’ve covered just two of eight warm-weather games.

Since 2021, the Arizona Cardinals are the third-best ATS team following an outright loss (12-6).

New York Jets vs. Denver Broncos Odds

  • Spread
    Broncos -2
  • Moneyline
    Jets +110, Broncos -130
  • Total
    43

Unders are 14-7 in New York Jets games since the beginning of last season.

The Denver Broncos are just 3-7 ATS in their past 10 home games.

Kansas City Chiefs vs. Minnesota Vikings Odds

  • Spread
    Chiefs -5
  • Moneyline
    Chiefs -225, Vikings +185
  • Total
    53

No team in the NFL is cashing over tickets when on the road at a higher rate since 2021 than the Kansas City Chiefs (68.4%).

The Minnesota Vikings have failed to cover seven of their past 10 games following an outright win.

Dallas Cowboys vs. San Francisco 49ers Odds

  • Spread
    49ers -3.5
  • Moneyline
    Cowboys +142, 49ers -170
  • Total
    45

Since 2021, the Dallas Cowboys are 10-1 ATS when facing a top-10 run defense.

This game involves two of the three best ATS teams when favored since 2021. The San Francisco 49ers are in that spot this week and are looking to improve upon their 20-12 ATS mark over that stretch.

Green Bay Packers vs. Las Vegas Raiders Odds

  • Spread
    Packers -2.5
  • Moneyline
    Packers -135, Raiders +114
  • Total
    44.5

There hasn’t been a better warm-weather ATS team since 2021 than the Green Bay Packers (7-1).

The Las Vegas Raiders are 0-2 this season after a loss, dropping their mark to 3-8 since the beginning of last season in such spots (fourth worst).

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