How did your Week 1 go? Ready for the second week? Before you take a look at the NFL Week 2 odds and spreads, take a minute to consider these trends that have developed. If you’re curious as to how we are using these numbers, check out our latest PFN betting content, where we have everything from best bets to primetime Same Game Parlay builds!
Nobody can promise winners, but we can promise information. Grab a cup of coffee, pull up a chair, and allow me to run you through the NFL Week 2 odds and trends for each game!
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NFL Week 2 Odds and Betting Trends
All odds are from DraftKings Sportsbook and trends from Inside Edge. Click on the widget for each game to place your bet.
Minnesota Vikings vs. Philadelphia Eagles
- Spread
Eagles -7 - Moneyline
Vikings +240, Eagles -298 - Total
48.5
Last season, four teams saw their average game go over the total by more than three points: the Vikings (+4.0) and Eagles (+3.1) are both on that list.
Green Bay Packers vs. Atlanta Falcons
- Spread
Packers -1 - Moneyline
Packers -118, Falcons -102 - Total
41
Only the Cowboys have a better outright record since 2021 against top-10 run offenses than the Packers (9-5).
Las Vegas Raiders vs. Buffalo Bills
- Spread
Bills -8.5 - Moneyline
Raiders +300, Bills -380 - Total
47.5
Over the past two seasons, the Bills are 4-2 ATS when having a rest disadvantage and 5-2-2 ATS when coming off of an outright loss.
Baltimore Ravens vs. Cincinnati Bengals
- Spread
Bengals -3 - Moneyline
Ravens +142, Bengals -170 - Total
46.5
We all like the Ravens’ passing outlook under Todd Monken. Well, the Bengals are a league-best 6-1 ATS versus top-10 passing offenses since the beginning of 2021.
Seattle Seahawks vs. Detroit Lions
- Spread
Lions -5.5 - Moneyline
Seahawks +195, Lions -230 - Total
49
Since 2021, the ‘Hawks are 2-6 ATS following a week in which they lost outright as a favorite.
Los Angeles Chargers vs. Tennessee Titans
- Spread
Chargers -3 - Moneyline
Chargers -162, Titans +136 - Total
46
Over the past two seasons, unders are 14-4 when Tennessee plays at home, the highest mark among teams hosting games in Week 2 (77.8%).
Chicago Bears vs. Tampa Bay Buccaneers
- Spread
Buccaneers -3 - Moneyline
Bears +130, Buccaneers -155 - Total
41.5
The Bears are just 8-20 ATS as an underdog over the past two seasons. The only team with a worse cover rate in those spots is their Week 2 opponent (Tampa Bay).
Kansas City Chiefs vs. Jacksonville Jaguars
- Spread
Chiefs -3 - Moneyline
Chiefs -155, Jaguars +130 - Total
51
Since 2021, the Jags are just 4-8 ATS following a road win.
Indianapolis Colts vs. Houston Texans
- Spread
Colts -1.5 - Moneyline
Colts -122, Texans +102 - Total
40
The Colts are just 1-5-1 outright as a favorite since the beginning of last season.
San Francisco 49ers vs. Los Angeles Rams
- Spread
49ers -8 - Moneyline
49ers -360, Rams +280 - Total
44.5
Unders went 5-0 last season when the 49ers played a bottom-10 rush defense.
New York Giants vs. Arizona Cardinals
- Spread
Giants -5.5 - Moneyline
Giants -205, Cardinals +170 - Total
40.5
The Giants were a perfect 7-0 ATS last season following a loss with an average margin of victory of 7.3 points.
New York Jets vs. Dallas Cowboys
- Spread
Cowboys -8.5 - Moneyline
Jets +310, Cowboys -395 - Total
40.5
Last season, the average Jets game came in 5.5 points below the projected total, the lowest number since the 2018 Jaguars. Without their star QB, New York faces a Dallas defense fresh off of a shutout.
MORE: Early NFL Week 2 Predictions and Picks
Washington Commanders vs. Denver Broncos
- Spread
Broncos -3.5 - Moneyline
Commanders +145, Broncos -175 - Total
39
Over the past two seasons, unders are 18-4 when Denver plays outside the division (81.8%).
Miami Dolphins vs. New England Patriots
- Spread
Dolphins -2.5 - Moneyline
Dolphins -142, Patriots +120 - Total
47
Overs were 6-3 last season when the Dolphins were off of a win, the highest rate among the teams that won last week.
New Orleans Saints vs. Carolina Panthers
- Spread
Saints -3.5 - Moneyline
Saints -166, Panthers +140 - Total
40
The Panthers boasted the fourth-best ATS record in divisional games last season at 5-1 (the Saints were a league-worst 1-5 ATS in those spots).
Cleveland Browns vs. Pittsburgh Steelers
- Spread
Browns -2 - Moneyline
Browns -125, Steelers +105 - Total
40.5
Over the past five seasons, unders are 8-3 when Pittsburgh is a home ‘dog (72.7%, only the Falcons have a higher such rate).