The Buffalo Bills will face the San Francisco 49ers in Week 13. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, especially regarding RB James Cook.
Is James Cook Playing in Week 13?
Cook is not listed on the injury report this week, so barring any setbacks, he is on track to play this weekend.
We’ll continue to monitor the Bills’ injury report. You can also visit and bookmark our NFL Injury Tracker and Fantasy News Tracker for the latest updates.
Should You Start or Sit James Cook in Week 13?
James Cook has returned great profits on your investment this summer with six RB1 finishes this season, including in three of his past four games as he trends toward matchup-proof status.
Cook has remained plenty involved in the passing game (15 targets over his past three games), but there is no denying that his biggest growth from last season to this one is in his ability to find paydirt with eight more rushing scores this year on 100 fewer carries than 2023.
The spiking touchdown rate has fueled a 23.8% increase in PPR points per touch for Cook, and while Ray Davis has looked the part when given the opportunity, it’s clear that Buffalo is comfortable with a bell-cow situation.
The 49ers own a top-10 run defense in nearly every metric you should be interested in, and while that hurts the upside case for Cook this week, his volume and versatility keep him ranked as a must-start in all formats without much question.
Are you looking for start/sit advice for other players in your lineup? Read our Week 13 Fantasy Start-Sit Advice Cheat Sheet for every fantasy-relevant player in every game.
James Cook’s Fantasy Points Projection in Week 13
As of 8 AM ET on Sunday morning, Cook is projected to score 14.8 fantasy points in PPR formats. This includes 15.7 rushing attempts for 81.8 yards and 0.2 touchdowns. It also includes 1.3 receptions for 29 yards and 0.2 touchdowns.
Check out the free PFN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.
PFN Insight on the Chiefs' Defense
The Chiefs were a top-10 defense entering Week 18 but saw their ranking tank after the backups flopped against the Broncos.
With the varsity team back for the Divisional Round, Kansas City demonstrated the type of disruptiveness this unit can generate at full strength. Steve Spagnuolo's blitz-heavy game plan overwhelmed the Texans. The Chiefs generated pressure on 73.3% of their blitzes against Houston, the highest by any team to send 15+ blitzes in a game this season.
The only area of concern to emerge from the Divisional Round was the third-down defense. Excluding Week 18, Kansas City allowed its second-highest third-down conversion rate (58.8%) all season. The only higher rate they allowed was to their AFC Championship Game opponent, as the Bills converted 60% of their third downs in Week 11.
After some shaky weeks and midseason questions, the Chiefs appear to be peaking ahead of their eighth straight AFC title game. That's a familiar story and could result in a familiar ending in February as well.
For more insight on all other team defenses, head to our PFN Defense+ Metric Analysis.Â
James Cook’s Fantasy Ranking
Our Weekly Consensus PPR Rankings are below — both positional and overall. They were last updated at 11:45 PM ET on Saturday, January 25.Â
Conference Championship RB PPR Rankings
1) Saquon Barkley | PHI (vs. WAS)
2) James Cook | BUF (at KC)
3) Brian Robinson Jr. | WAS (at PHI)
4) Isiah Pacheco | KC (vs. BUF)
5) Kareem Hunt | KC (vs. BUF)
6) Austin Ekeler | WAS (at PHI)
7) Ray Davis | BUF (at KC)
8) Ty Johnson | BUF (at KC)
9) Samaje Perine | KC (vs. BUF)
10) Kenneth Gainwell | PHI (vs. WAS)
11) Jeremy McNichols | WAS (at PHI)
12) Will Shipley | PHI (vs. WAS)
13) Carson Steele | KC (vs. BUF)
14) Reggie Gilliam | BUF (at KC)
15) Chris Rodriguez Jr. | WAS (at PHI)
Bills at Chiefs Trends and Insights
Buffalo Bills
Team: The Bills lost four road games during the regular season — only four Super Bowl champions in the 2000s have done that (2018 Patriots, 2012 Ravens, 2010 Packers, and 2006 Colts).
QB: Five times has a QB had four games in a season (playoffs included) with multiple rush touchdowns and 20 pass attempts.
- 2021 Jalen Hurts
- 2022 Jalen Hurts
- 2023 Jalen Hurts
- 2023 Josh Allen
- 2024 Josh Allen
No player has had five such games in a season.
Offense: The Bills have scored on at least 55% of their possessions six times this season, four of which have come against playoff teams.
Defense: Buffalo allowed Baltimore to pick up 70% of their third downs. That’s the fourth-highest rate the Bills have allowed in the 2000s and is their highest in a winning effort.
Fantasy: Allen has completed over 72% of his passes in both playoff wins – he had three such games during the regular season.
Betting: Overs are 5-2 in Buffalo’s past seven games, cashing last week by half a point with Baltimore's final touchdown.
Kansas City Chiefs
Team: Christmas Day 2023 was the date of Kansas City’s last home loss – each of their past six Arrowhead games have been decided by a single possession.
QB: Patrick Mahomes has thrown a total of three touchdown passes in his last two Championship games (3.7% of his attempts) after throwing three in each of his first four appearances (8.4%).
Offense: Saturday was the 10th time this season in which the Chiefs scored on at least half of their possessions (five-of-nine against Houston).
Defense: Opponents have picked up at least half of their third downs in four straight games against the Chiefs (Texans: 10-of-17).
Fantasy: In the last two games in which their starters have been extended, the Chiefs have managed to turn 42 carries into just 119 yards (2.83 yards per carry).
Betting: By taking an intentional safety at the end of their win over the Texans, the Chiefs snapped their six-game playoff cover streak.
