Isaac Guerendo Fantasy Hub: Week 3 Injury Update, Start ‘Em/Sit ‘Em Advice, Points Projection, and Weather Impact

Here's this week's fantasy football outlook for Isaac Guerendo, including injury updates, start-sit advice, points projection, and weather impact.

The San Francisco 49ers will host the Arizona Cardinals in Week 3. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, specifically regarding RB Isaac Guerendo.

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Is Isaac Guerendo Playing in Week 3?

Guerendo is not on the injury report and is expected to play.

We’ll continue to monitor the 49ers’ injury report leading up to kickoff for any changes. You can also visit and bookmark our Fantasy News Tracker for the latest updates.

Should You Start or Sit Isaac Guerendo in Week 3?

I guess we can look at the glass 59.6% full in the case of Isiah Pacheco. That was his snap share last week, up from 48.3% in the season opener, a step in the right direction, but still a long way away from what it’ll take to get him back into fantasy lineups.

Andy Reid always runs a high pass rate over expectation offense and I would to if I had Patrick Mahomes, but what I didn’t see coming was the willingness to have Mahomes move the chains himself.

We normally see #15 peak in an athletic sense when the games mean more in the winter, but as the Chiefs search for answers, he’s going that route with regularity and it’s leaving the running backs without much work.

Pacheco doesn’t yet have a gain of more than 10 yards this season and only has 20 opportunities (rush attempts plus targets) through two weeks.

I still think this offense functions better with Pacheco’s profile than it does Kareem Hunt’s, but neither deserve to be anywhere near your lineup until Kansas City stabilizes their usage patterns.

Are you looking for start/sit advice for other players in your lineup? Read our Fantasy Football Start ‘Em, Sit ‘Em Cheat Sheet.

Guerendo’s Fantasy Points Projection in Week 3

Guerendo is projected to score 0.0 points in PPR formats.

Check out the free PFSN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.

Week 3 Weather Impact: Cardinals at 49ers

The forecast for 4:25 PM ET kickoff is 81 degrees Fahrenheit with 6 mph winds. These are ideal conditions for fantasy production.

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