The clock continues ticking toward Joe Mixon’s potential return from the NFI list. But how realistic is that scenario?
The Houston Texans’ RB1 has been absent all season with a foot injury, and the organization has maintained mostly silence on his status. For fantasy football managers who invested in him, what are the chances of getting Mixon back anytime soon?
Joe Mixon Injury Update
Mixon continues his stay on the reserve/non-football injury list, which mandates a minimum four-game absence. This is the final week he’s required to miss, but there has been zero indication that the veteran rusher will be activated when first eligible.
The injury happened during the offseason while Mixon was training away from the team facility. The specific circumstances surrounding the incident remain undisclosed, but the injury is confirmed to involve his foot and ankle. What initially seemed like a minor setback has evolved into something far more problematic, sidelining him for the entire offseason.
Physical therapy specialist Jeff Mueller, who provides injury analysis for fantasy football, has revealed troubling information about Mixon’s situation. According to his research, the available evidence points to this being an aggravation of previous injuries rather than a new issue requiring surgical intervention.

Mixon endured a right high ankle/deltoid injury in September and a left ankle injury in December of last season. He was observed wearing a brace on his left ankle as early as May, suggesting ongoing complications from those previous ailments.
The earliest Mixon could theoretically return would be Week 5 against the Baltimore Ravens on October 6. With Houston’s Week 6 bye immediately following, it’s logical to assume the team would provide Mixon those additional recovery days.
Three weeks into the season, fantasy managers remain without concrete information on Mixon’s status. Head coach DeMeco Ryans has persistently avoided providing substantive updates on Mixon’s recovery, intensifying the uncertainty around his timeline.
Most concerning for fantasy managers were Ryans’ press conference remarks, which appeared to reference Mixon in the past tense. “We’re rolling with the guys that are here,” Ryans stated. That’s the main thing. We miss Joe, miss his energy, enthusiasm, and everything he brought to the team.”
The language sparked immediate concerns among observers about whether Mixon would return at all this season.
Joe Mixon Injury Update: How Long Will the Texans RB Be Out With Mysterious Ankle Issue?
Texans general manager Nick Caserio has maintained an equally evasive stance when questioned about Mixon’s availability for the entire 2025 season. “We’ll see. We’ll take it one day at a time,” Caserio said. “We’ll evaluate those players after four weeks and see where they are in their progression and then make a determination.”
Since we’ve heard absolutely nothing from the team since the last update and there’s been no indication that Mixon is anywhere close to returning to practice, managers should continue to operate under the assumption that Mixon won’t play football in 2025.
The fact that Mixon hasn’t been spotted working on a rehab field or participating in individual workouts suggests the star running back remains far from returning to game action.
Joe Mixon Fantasy Outlook
In his inaugural year with the Texans, Mixon compiled 1,016 rushing yards and 11 touchdowns on 245 carries while contributing 36 catches for 309 yards and another score. He paced the team in total touchdowns during both the regular season (12) and playoffs (2), becoming the cornerstone of the offense.
With Mixon unavailable indefinitely, the Texans have attempted to replace his production with a collection of running backs. The backfield has undergone significant changes over the past three weeks, with clear decisions made about the depth chart hierarchy.
We did see a shift in this backfield in Week 3. Dameon Pierce is now a weekly inactive, and Dare Ogunbowale doesn’t see the field. It’s down to a clear split between Nick Chubb as the early-down bruiser and Woody Marks as the receiving back.
The former Cleveland Browns standout will continue managing the early-down responsibilities, though he has appeared diminished since returning from his own injuries that have sapped his explosiveness.
MORE: Free Fantasy Waiver Wire Tool
Chubb’s snap share is sitting consistently around 50%, making him a touchdown-or-bust RB3 option for fantasy purposes. The veteran previously earned four consecutive Pro Bowl selections from 2019-2022 before injuries disrupted his trajectory.
Meanwhile, Marks has emerged as the receiving back and represents a bench stash for fantasy managers. He could earn a larger role as the season progresses if Chubb continues to underwhelm with his current level of production.
If Mixon can return and achieve full health, he will reclaim his complete role in what should be a workhorse capacity.
Fantasy managers who drafted Mixon don’t need to waste a roster spot as he remains IR eligible, but must wait for an indefinite period. The ambiguity surrounding his injury creates a massive gamble despite the potential league-winning reward if he returns healthy. It remains entirely possible, if not probable, that he doesn’t compete in 2025.
