The Seattle Seahawks will host the San Francisco 49ers in Week 1. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, specifically regarding WR Cooper Kupp.
Is Cooper Kupp Playing in Week 1?
Kupp is not listed on the injury report this week, so barring any setbacks, he will play.
We’ll continue to monitor the Seahawks’ injury report leading up to kickoff for any changes. You can also visit and bookmark our Fantasy News Tracker for the latest updates.
Should You Start or Sit Cooper Kupp in Week 1?
I’m proud of us as a community.
Cooper Kupp has prominent name recognition and is starting a new situation with not only a quarterback coming off a career year but also one that lacks much target competition behind him on the depth chart.
If you wanted to sell yourself on a huge age-32 season, you could have convinced yourself. We all could have jammed Kupp inside the top-30 of the position in terms of ADP and been content to draft him at, or above, his 2025 ceiling.
But we showed restraint. Go us!
I fear, however, that the job isn’t done. Every advanced metric points to physical decline and uneven production coming up. We all seem to be on board with that general premise, but we see Week 1 overreactions occur every year.
The 49ers were the seventh-worst defense per Defense+ last season, and it’s reasonable to project similar struggles to continue through 2025. Combine that with the fact that Kupp has reached triple-figure receiving yards in each of his past four season openers (average numbers: 10.5 catches for 115.3 yards), and there’s a world in which Kupp clears our modest Week 1 projections and generates some excitement in your league.
“Uneven production”
We agreed that there would be ups and downs. It’s easy to get carried away with the first data point of the season. Be careful. You can squint and see a flex option in Kupp in this matchup if it makes you feel good (personally, he’s at the back-end of that conversation, not the front), but should he go nuts in this perfect spot at full strength, remember where you stood on his outlook before kickoff.
Are you looking for start/sit advice for other players in your lineup? Read our Week 1 Fantasy Football Start ‘Em, Sit ‘Em article.
Cooper Kupp’s Fantasy Points Projection in Week 1
Kupp is projected to score 10.9 points in PPR formats. This includes 3.9 receptions for 46.5 yards and 0.4 touchdowns.
Check out the free PFSN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.
Week 1 Weather Impact: Seahawks vs 49ers
Weather could be a factor in this outdoor game with temperatures at 65 degrees Fahrenheit and winds of 11 mph. The wind may impact deep passes and field goal attempts.

Who else can they throw to? Honestly. Kupp at 80% is still better then 60% of the league WR.