The San Francisco 49ers will travel to take on the Seattle Seahawks in Week 1. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, specifically regarding RB Christian McCaffrey.
Is Christian McCaffrey Playing in Week 1?
Update: ESPN’s Adam Schefter reported that Christian McCaffrey will play today.
49ers RB Christian McCaffrey, who was added to the injury report Thursday with a calf issue, will play today vs. the Seahawks. “He’s good to go,” said one source. pic.twitter.com/K58t9DFlhq
— Adam Schefter (@AdamSchefter) September 7, 2025
McCaffrey (calf), who is officially listed as questionable for Sunday’s road game against the Seahawks, is expected to suit up unless he suffers any setbacks, Ian Rapoport of NFL Network reports.
We’ll continue to monitor the 49ers’ injury report leading up to kickoff for any changes. You can also visit and bookmark our Fantasy News Tracker for the latest updates.
Should You Start or Sit Christian McCaffrey in Week 1?
You did it. If you’re reading this, you took the plunge on Christian McCaffrey this summer, and for that, I commend you. It’s a move made by managers who enjoy winning more than they fear losing, and that’s generally how I like to approach this game.
You’ve done the hard part. Now, you just sit back and watch. And hope. And maybe pray, if that’s your thing.
McCaffrey, famous for never leaving the field when he’s at the peak of his powers, has been a fantasy monster for as long as we’ve known him. Consider this: in games where he has played even 80% of the offensive snaps, a low bar for him to clear, he has averaged 25.8 PPR points per game.
That’s a 55-game sample of production that is almost impossible to grasp. His output in those games surpasses the 2024 season’s RB1, Saquon Barkley, by more points per game than the margin that separated Barkley from RB5 Alvin Kamara. In fact, that 25.8 number is more than a pair of top-24 running backs from last season, D’Andre Swift and Tony Pollard, combined.
As far as we know, the CMC plan is in full effect for the San Francisco 49ers. The team profiles as less potent than in years past, and with that, McCaffrey isn’t likely to come off the field. You already know that. You’re looking for a quirky stat to highlight his greatness, and I’m nothing if not a man of the people.
So, here it is: McCaffrey has averaged 25.9 PPR points over his last 10 games against bird-themed teams.
Are you looking for start/sit advice for other players in your lineup? Read our Week 1 Fantasy Football Start ‘Em, Sit ‘Em article.
Christian McCaffrey’s Fantasy Points Projection in Week 1
McCaffrey is projected to score 22.6 points in PPR formats. This includes 80.3 rushing yards, 0.4 rushing touchdowns, 5.4 receptions for 48.6 receiving yards, and 0.3 receiving touchdowns.
Check out the free PFSN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.
Week 1 Weather Impact: 49ers at Seahawks
Weather could be a factor in this outdoor game with temperatures at 65 degrees Fahrenheit and winds of 11 mph. The wind may impact deep passes and field goal attempts.
