Iowa State forward Joshua Jefferson was forced to leave the Cyclones’ first-round March Madness matchup against the Tennessee State Tigers with a suspected ankle injury. Jefferson appeared to twist his ankle while attempting a layup and had to be helped off the floor.
The incident occurred just three minutes into the contest. Iowa State will now await word on his availability for the remainder of the NCAA Tournament.
Jefferson landed awkwardly after the attempt and was unable to put any weight on his left foot. He was helped to the locker room, and the CBS broadcast later revealed he has been ruled out for the rest of the game.
Joshua Jefferson Ruled Out of Iowa State Opening Round with Ankle Injury
Iowa State’s Joshua Jefferson was helped off the floor after an apparent ankle injury pic.twitter.com/R4xaFzgsJU
— CBS Sports College Basketball 🏀 (@CBSSportsCBB) March 20, 2026
Jefferson left the floor to undergo an X-ray to determine the extent of the injury, according to The Athletic’s Chris Vannini. The senior was later seen sitting on the team’s bench with his left leg in a walking boot. The results of the imaging will determine whether he can play any further part in the team’s tournament run.
MORE: March Madness: Ranking The Paths for Michigan, Duke, Arizona, and Florida
The Cyclones raced to a 55-24 lead going into the halftime break against Tennessee State, with Milan Momcilovic, Nate Heise, and Killyan Toure leading the scoring effort. If Iowa State maintains its lead to defeat the Tigers, the No. 2 seed will face the No. 7 Kentucky Wildcats in the second round on Sunday.
Jefferson’s Role in the Iowa State Frontcourt
If Jefferson is unable to recover in time for Sunday’s potential matchup, his absence would represent a significant blow to the Cyclones’ hopes of making a deep postseason run.
MARCH MADNESS: Fill In Your Bracket Now!
The senior is averaging 16.9 points, 7.6 rebounds, 4.9 assists, and 1.7 steals per game this year. He is shooting 47% from the field and 34.5% from 3-point range.
Additionally, Jefferson had scored at least 10 points in every game this season prior to his early exit against Tennessee State. He has also recorded two triple-doubles for Iowa State during the current campaign.
Jefferson serves as a vital leader for the frontcourt, having earned consensus second-team All-American honors for his regular-season performance. An extended absence would severely impact the Cyclones’ championship aspirations.

