Our Missouri vs. Vanderbilt prediction spotlights one of Week  9’s most compelling matchups between two programs surging up the SEC standings. The 15th‑ranked Missouri  Tigers travel to Nashville to take on the 10th‑ranked Vanderbilt  Commodores in a clash that could significantly shape the conference and playoff outlook.
Our in-depth breakdown features the latest game details, head-to-head record, exclusive PFSN player and team grades, concluding with a score forecast for this must-watch matchup.
Missouri vs. Vanderbilt Details
- Date:Â Saturday, Oct. 25, 2025
- Game time:Â 3:30 p.m. EST
- Location:Â FirstBank Stadium, Nashville, Tenn.
- Predicted weather at kick:Â 70 degrees, partly cloudy
- How to watch:Â ESPN
Missouri vs. Vanderbilt Head-to-Head Record
The rivalry between Missouri and Vanderbilt dates back to 1895, though their first tie came during the  1957  season. Since that early meeting, the Tigers have largely controlled the series, winning  11 of the 15  contests played and each of the last  five  matchups.
As both programs continue to climb the SEC ladder, the history adds extra intrigue to this weekend’s clash. Vanderbilt has shown a recent ability to challenge opponents it once struggled against, while Missouri remains one of the most well-rounded teams in the conference.
The long‑standing series sets the stage for a physical, passionate showdown between two squads eager to keep their momentum alive.
Missouri vs. Vanderbilt Grades
- Missouri (86.7, B)
- Vanderbilt (92.1, A-)
- Missouri (89, B+)
- Vanderbilt (80.4, B-)
- Missouri (85.8, B)
- Vanderbilt (82.3, B-)
- Beau Pribula, Missouri (81.7, B-)
- Diego Pavia, Vanderbilt (86.3, B)
- Ahmad Hardy, Missouri (83, B-)
- Sedrick Vanderbilt, Vanderbilt (82.4, B-)
- Kevin Coleman, Missouri (80.8, B-)
- Junior Sherrill, Vanderbilt (75.7, C)
- Brett Norfleet, Missouri (77.8, C+)
- Eli Stowers, Vanderbilt (80.8, B-)
- Zion Young, Missouri (85.8, B)
- Khordae Sydnor, Vanderbilt (78.7, C+)
- Chris McClellan, Missouri (75.9, C)
- Zaylin Wood, Vanderbilt (76.7, C)
- Khalil Jacobs, Missouri (73.6, C)
- Bryan Longwell, Vanderbilt (71.2, C-)
- Daylan Carnell, Missouri (79.2, C+)
- Mark Davis, Vanderbilt (84, B)
- Santana Banner, Missouri (79.7, C+)
- CJ Heard, Vanderbilt (72.2, C-)
Missouri vs. Vanderbilt Prediction
With significant implications for the College Football Playoff at stake, these top-25 teams will both want to make a statement. The 15th-ranked Missouri Tigers took down Auburn on the road in double overtime last time, while 10th-ranked Vanderbilt made a statement, taking down LSU and moving up to 10th in the rankings.
This is a clash of the top offense in the nation (Vanderbilt) facing off with the seventh-ranked defense (Missouri). I think that Missouri will struggle to contain Diego Pavia, and Vanderbilt will be motivated by the 30-27 loss in double overtime in Columbia. They responded to every punch Missouri threw at them, but missed a field goal in overtime, which cost them the game. They have even made a believer out of Nick Saban.
“I have picked against Vanderbilt time and time again..
I want everybody out there to know that I am a J O…
I’m jumping on the bandwagon” ~ Coach Saban
That could have meant a lot of things Coach 😂😂#PMSLive pic.twitter.com/JT1xtLyoHn
— Pat McAfee (@PatMcAfeeShow) October 24, 2025
Luther Burden III is on to the NFL, and Vanderbilt is at home, fully manned and ready to make a run this season. Everyone who has come their way has gotten an intense fight, and they will feel like they can hang with anyone after taking down both top-15-ranked teams and only losing one of those games.
Prediction: Vanderbilt 31, Missouri 24
