The New York Giants and the Philadelphia Eagles kicked off Week 6 of the 2025 NFL season on Thursday Night Football. The Giants pulled off a massive upset, winning 34-17, shocking everyone.
The Eagles started the season 4-0 but have lost two straight games since then. Teams like the Tampa Bay Buccaneers, Green Bay Packers, Detroit Lions, and San Francisco 49ers can take advantage of Philadelphia’s loss this week to strengthen their position to finish the season as the top seed in the NFC.
However, all these teams and others across the league will miss several star players this week. Here is the complete list of inactives for Week 6:
NFL Inactives for Week 6
Arizona Cardinals at Indianapolis Colts
Cardinals quarterback Kyler Murray is dealing with a foot injury and is officially out against the Colts. There is a possibility that Murray could miss more time, and in his absence, Jacoby Brissett will lead the team.
Arizona is 2-3 on the season and has lost its last three games. Things could turn ugly for the NFC West franchise without Murray, who is currently the 23rd-ranked quarterback in the league based on PFSN’s QB Impact metric.
Cardinals designated as out:
- QB Kyler Murray
- OL Josh Fryar
- OL Demontrey Jacobs
- CB Elijah Jones
- DL Bilal Nichols
- DL Darius Robinson
- WR Xavier Weaver
Colts designated as out:
- RB Tyler Goodson
- TE Will Mallory
- WR Adonai Mitchell
- CB Kenny Moore II
- QB Anthony Richardson
- T Luke Tenuta
- DE JT Tuimoloau
Los Angeles Chargers at Miami Dolphins
Chargers designated as out:
- WR Quentin Johnston
- WR Derius Davis
- FB/DL Scott Matlock
- CB Nikko Reed
- OL Jamaree Salyer
- T Joe Alt
- G/T Trey Pipkins III
Dolphins designated as out:
- QB Quinn Ewers
- RB Jaylen Wright
- CB Storm Duck
- DT Zeek Biggers
- LB Tyrel Dodson
- WR Cedrick Wilson Jr.
- DB Elijah Campbell
Dallas Cowboys at Carolina Panthers
Cowboys designated as out:
- WR CeeDee Lamb
- WR KaVontae Turpin
- OG Tyler Booker
- LB Jack Sanborn
- OT Ajani Cornelius
- DT Mazi Smith
Panthers designated as out:
- TE Ja’Tavion Sanders
- CB Akayleb Evans
- RB Chuba Hubbard
- S Trevian Thomas
- RT Taylor Moton
- DT Jaden Crumedy
- DT Tershawn Wharton
New England Patriots at New Orleans Saints
Patriots designated as out:
- QB Tommy DeVito
- OLB Anfernee Jennings
- DE Keion White
- S Jaylinn Hawkins
- OL Caedan Wallace
- DT Eric Gregory
Saints designated as out:
- S Ugo Amadi
- CB Rejzohn Wright
- CB Isaac Yiadom
- OL Torricelli Simpkins III
- OL Xavier Truss
- DT Khristian Boyd
Cleveland Browns at Pittsburgh Steelers
Browns designated as out:
- CB Jarrick Bernard-Converse
- RB Raheim Sanders
- T Thayer Munford Jr.
- G Zak Zinter
- T Cornelius Liucas
- DT Mike Hall Jr.
Steelers designated as out:
- WR Calvin Austin III
- S Chuck Clark
- G Andrus Peat
- DL Logan Lee
- DE DeMarvin Leal
Seattle Seahawks at Jacksonville Jaguars
Seahawks designated as out:
- QB Jalen Milroe
- S Julian Love
- CB Devon Witherspoon
- CB Riq Woolen
- LB Derick Hall
- OL Josh Jones
- TE Nick Kallerup
Jaguars designated as out:
- S Kahlef Hailassie
- RB Cody Schrader
- LB Yasir Abdullah
- OL Robert Hainsey
- DT Khalen Saunders Sr.
Los Angeles Rams at Baltimore Ravens
Lamar Jackson did not practice this week and will miss his second straight game due to the hamstring injury he suffered against the Kansas City Chiefs.
Cooper Rush will get his second start as the Ravens quarterback. However, Tyler Huntley is expected to see some playing time. It will be interesting to see how Baltimore’s defense performs this week against the Rams, as it is currently the second-worst-ranked unit in the league based on PFSN’s Defense Impact metric.
Rams designated as out:
- WR Tutu Atwell
- LB Omar Speights
- OG Beaux Limmer
- RT Rob Havenstein
- TE Colby Parkinson
- DE Deshaun Johnson
Ravens designated as out:
- QB Lamar Jackson
- FB Pat Ricard
- WR Devontez Walker
- OT Carson Vinson
- DT Aeneas Peebles
- MLB Roquan Smith
- CB Chidobe Awuzie
Tennessee Titans at Las Vegas Raiders
Titans designated as out:
- K Joey Slye
- DB Marcus Harris
- OLB Arden Key
- OL Blake Hance
- OL Brandon Crenshaw-Dickson
- WR Bryce Oliver
- TE Thomas Odukoya
Raiders designated as out:
- TE Brock Bowers
- RB Zamir White
- DT JJ Pegues
- DT Tonka Hemingway
- OL Caleb Rogers
Cincinnati Bengals at Green Bay Packers
Bengals designated as out:
- CB Marco Wilson
- G Dylan Fairchild
- WR Jermaine Burton
- TE Cam Grandy
- DL Jordan Jefferson
- DL Shemar Stewart
Packers designated as out:
- K Brandon McManus
- CB Kamal Hadden
- OL Anthony Belton
- DL Devonte Wyatt
San Francisco 49ers at Tampa Bay Buccaneers
49ers designated as out:
- WR Ricky Pearsall
- WR Jordan Watkins
- RB Jordan James
- DL Yetur Gross-Matos
- LB Nick Martin
- QB Brock Purdy
Buccaneers designated as out:
- WR Mike Evans
- WR Chris Godwin
- RB Bucky Irving
- CB Zyon McCollum
- CB Benjamin Morrison
- RB Josh Williams
Detroit Lions at Kansas City Chiefs (SNF)
Lions designated as out:
- RB Sione Vaki
- DT Alim McNeil
- LB Zach Cunningham
- CB Terrion Arnold
- CB Avonte Maddox
- DL Mekhi Wingo
- S Loren Strickland
Chiefs designated as out:
- CB Kristian Fulton
- TE Jared Wiley
- RB Elijah Mitchell
- OT Josh Simmons
- DE Malik Herring
Buffalo Bills at Atlanta Falcons (MNF)
Bills designated as out:
- S Damar Hamlin (IR)
- LB Matt Milano
- TE Dalton Kincaid
- WR Curtis Samuel
- LB Jimmy Ciarlo
- OL Chase Lundt
Falcons designated as out:
- WR Darnell Mooney
- WR Ray-Ray McCloud III
- CB Clark Phillips III
- RB Nathan Carter
- CB Billy Bowman
- DL LaCale London
- OL Jack Nelson
Chicago Bears at Washington Commanders (MNF)
Bears designated as out:
- K Cairo Santos
- QB Case Keenum
- WR Jahdae Walker
- LB Ruben Hyppolite II
- DT Grady Jarrett
- G Luke Newman
- DE Tanoh Kpassagnon
Commanders designated as out:
- WR Noah Brown
- WR Terr McLaurin
- QB Josh Johnson
- LB Kain Medrano
- G Brandon Coleman
- DT Eddie Goldman
- LB Ale Kaho
