With our sample size growing, our ability to handicap teams in specific spots should be more accurate. The NFL Week 6 odds board is loaded with big favorites and a home underdog to finish the week. What do the trends have to say about the upcoming action?
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NFL Week 6 Odds and Betting Trends
All odds are from DraftKings Sportsbook and trends from Inside Edge.
Denver Broncos vs. Kansas City Chiefs Odds
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- Spread
Chiefs -10.5 - Moneyline
Broncos +380, Chiefs -500 - Total
47.5
- Spread
The Denver Broncos are 3-6 ATS on the road since the beginning of last season, second-worst in the league over that stretch (Chicago Bears).
At kickoff, it will have been 2,947 days (15 games) since the last time the Broncos beat the Kansas City Chiefs.
Baltimore Ravens vs. Tennessee Titans Odds (London)
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- Spread
Ravens -4.5 - Moneyline
Ravens -205, Titans +170 - Total
40.5
- Spread
No team cashes under tickets when favored since 2021 at the rate of the Baltimore Ravens (20-7, 74.1%).
Tennessee is winless against top-10 rush offenses since the beginning of last season (0-6). Lamar Jackson has as many rush TDs as pass TDs and is pacing for over 900 yards on the ground this season.
Washington Commanders vs. Atlanta Falcons Odds
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- Spread
Falcons -2.5 - Moneyline
Commanders +120, Falcons -142 - Total
42.5
- Spread
Since 2021, unders are 11-6 when the Washington Commanders play a top-10 rush offense.
MORE: Early NFL Week 6 Picks and Predictions Against the Spread
Since 2021, the Atlanta Falcons are a league-worst 3-11 ATS following an outright win.
Minnesota Vikings vs. Chicago Bears Odds
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- Spread
Vikings -2.5 - Moneyline
Vikings -142, Bears +120 - Total
44.5
- Spread
The Minnesota Vikings have won three straight at Soldier Field, outscoring the Bears 65-35 in the process.
Since 2021, the Bears are the worst ATS team in the league (12-25) and have lost 15 of 16 games outright when opposing a top-10 offense.
Seattle Seahawks vs. Cincinnati Bengals Odds
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- Spread
Bengals -3 - Moneyline
Seahawks +145, Bengals -175 - Total
45.5
- Spread
Overs are 6-3 since the beginning of last season when the Seattle Seahawks play on the road.
Think the Seahawks are a top-10 pass offense? The Cincinnati Bengals are a league-best 6-2 ATS when facing such a team since the beginning of 2021.
San Francisco 49ers vs. Cleveland Browns Odds
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- Spread
49ers -6.5 - Moneyline
49ers -300, Browns +245 - Total
37.5
- Spread
The San Francisco 49ers are 21-12 ATS as a favorite since the beginning of 2021 (fourth-best).
MORE: Brock Purdy NFL MVP Odds Update
The Cleveland Browns have failed to cover seven of their past 10 against top-10 offenses.
Carolina Panthers vs. Miami Dolphins Odds
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- Spread
Dolphins -13.5 - Moneyline
Panthers +550, Dolphins -800 - Total
48.5
- Spread
Overs have cashed in 10 of the Carolina Panthers’ past 13 games against a top-10 passing offense.
The Miami Dolphins are 16-8 ATS since 2021 when playing in warm weather — early forecasts are projecting 90 degrees for kickoff.
Indianapolis Colts vs. Jacksonville Jaguars Odds
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- Spread
Jaguars -4.5 - Moneyline
Colts +164, Jaguars -198 - Total
45.5
- Spread
The Jacksonville Jaguars’ win at Indianapolis in Week 1 snapped an 11-game win streak for the home team in this series. The last time the road team won both meetings in a single season was 2012 (Vick Ballard led the Colts in rushing that season).
Since 2021, the Jaguars have been the second-worst home ATS team (6-11, 35.3%).
New Orleans Saints vs. Houston Texans Odds
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- Spread
Saints -1.5 - Moneyline
Saints -125, Texans +105 - Total
42.5
- Spread
The New Orleans Saints have covered just three of their past 10 games when favored.
The Houston Texans are the fifth-worst team since 2021 ATS when playing a top-10 defense (4-8). The Saints come to town fresh off shutting out the New England Patriots in Week 5.
New England Patriots vs. Las Vegas Raiders Odds
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- Spread
Raiders -3 - Moneyline
Patriots +130, Raiders -155 - Total
41.5
- Spread
New England is a league-worst 5-13 ATS (27.8%) as an underdog since the beginning of 2021.
Under tickets have cashed in six of the past seven instances in which the Las Vegas Raiders won at home (they beat the Green Bay Packers on Monday night to end Week 5).
Arizona Cardinals vs. Los Angeles Rams Odds
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- Spread
Rams -6.5 - Moneyline
Cardinals +230, Rams -285 - Total
48.5
- Spread
The Arizona Cardinals are 12-7 ATS following an outright loss since the beginning of 2021 (sixth-best).
The Los Angeles Rams have won 11 of the past 13 meetings but have lost two of the past three games against the Cardinals playing at home.
Philadelphia Eagles vs. New York Jets Odds
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- Spread
Eagles -7 - Moneyline
Eagles -290, Jets +235 - Total
41
- Spread
Overs are 6-3 in Philadelphia Eagles games against top-10 run offenses, and the New York Jets certainly looked like that behind Breece Hall last weekend.
Unders are 8-2 in the last 10 games in which the Jets are getting more than a field goal.
Detroit Lions vs. Tampa Bay Buccaneers Odds
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- Spread
Lions -3 - Moneyline
Lions -162, Buccaneers +136 - Total
43.5
- Spread
Overs are 7-2 since 2021 when the Detroit Lions are favored, the highest rate in the league.
The Tampa Bay Buccaneers are the worst ATS team at home since the beginning of last season (2-7).
New York Giants vs. Buffalo Bills Odds
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- Spread
Bills -14 - Moneyline
Giants +575, Bills -850 - Total
44.5
- Spread
Under tickets have cashed at a 74.1% rate since 2021 when the New York Giants are underdogs; they are also 0-14 outright over that stretch vs. top-10 offenses, so don’t get cute.
The Buffalo Bills have covered eight of 12 games against bottom-10 pass offenses since 2021.
Dallas Cowboys vs. Los Angeles Chargers Odds
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- Spread
Cowboys -2 - Moneyline
Cowboys -130, Chargers +110 - Total
50.5
- Spread
Since 2021, the Dallas Cowboys are 9-1 following a loss (both outright and ATS). Both of those marks are tops in the league.
The Los Angeles Chargers have covered seven of their past 10 games following an outright victory.
