The NFL Week 16 betting lines feature a few big numbers and a ton of tight games as teams look to position themselves and/or qualify for the postseason. Add in winter weather on the East Coast and health concerns — these are the weeks where hard work is rewarded in a major way.
As you begin to consider your Week 16 betting card, let’s take a look at some trends that apply to this slate in an effort to understand these matchups a bit better. For early NFL Week 16 predictions and picks against the spread, we have you covered!
NFL Week 16 Odds and Betting Trends
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New Orleans Saints vs. Los Angeles Rams Odds
- Spread
Rams -4 - Moneyline
Saints +164, Rams -198 - Total
44.5
The Saints are just 3-9 against the spread (ATS) following an outright win since the beginning of last season.
The Rams have covered five of seven games when favored this season.
Cincinnati Bengals vs. Pittsburgh Steelers Odds
- Spread
Bengals -2.5 - Moneyline
Bengals -135, Steelers +114 - Total
37.5
After losing 11 straight to the Steelers, the Bengals have won four of the past six with three of those wins coming by double figures.
Overs are 8-5 since the beginning of last season when the Steelers are coming off of an outright loss.
Buffalo Bills vs. Los Angeles Chargers Odds
- Spread
Bills -10.5 - Moneyline
Bills -625, Chargers +455 - Total
42.5
Under tickets have cashed in 10 of Buffalo’s past 14 games against bottom-10 pass defenses.
MORE: Can the Bills Catch the Dolphins in the AFC East?
Unders are 5-2 this season when the Chargers play at home.
Detroit Lions vs. Minnesota Vikings Odds
- Spread
Lions -3 - Moneyline
Lions -162, Vikings +136 - Total
47
Think the Vikings’ improvement on the defensive end is here to stay? Back the road team. Detroit is 12-2 ATS against top-10 pass defenses since the beginning of last season, the highest cover rate in such spots.
The past five meetings in this series have been decided by an average of just 4.2 points (five of Minnesota’s past six losses in this NFC North rivalry have come by a single possession).
Green Bay Packers vs. Carolina Panthers Odds
- Spread
Packers -5 - Moneyline
Packers -225, Panthers +185 - Total
36.5
Since the beginning of last season, under tickets have cashed in seven of 10 games when the Packers oppose a bottom-10 pass defense.
Unders are 6-0 in Panther home games this season.
Cleveland Browns vs. Houston Texans Odds
- Spread
Texans -2.5 - Moneyline
Browns +120, Texans -142 - Total
42.5
The Browns are 1-4-1 ATS on the road this season (7-1 ATS at home).
Unders are 5-2 this season when the Texans play at home.
Indianapolis Colts vs. Atlanta Falcons Odds
- Spread
Colts -2.5 - Moneyline
Colts -135, Falcons +114 - Total
44
The Colts are a perfect 6-0 outright this season against bottom-10 passing offenses.
Unders are 12-4 since the beginning of last season when the Falcons are catching points.
Washington Commanders vs. New York Jets Odds
- Spread
Jets -3 - Moneyline
Commanders +130, Jets -155 - Total
38
Unders are 6-0 since the beginning of last season when the Commanders are getting three or fewer points.
MORE: PFN’s FREE NFL Playoff Predictor
The Jets have covered three of four games this season when facing a bottom-10 pass defense this season.
Seattle Seahawks vs. Tennessee Titans Odds
- Spread
Seahawks -2.5 - Moneyline
Seahawks -135, Titans +114 - Total
42
Unders are 5-2 this season when the Seahawks play on the road.
Unders have come through in nine of the last 11 games following a Titans outright victory.
Jacksonville Jaguars vs. Tampa Bay Buccaneers Odds
- Spread
Jaguars -1 - Moneyline
Jaguars -110, Buccaneers -110 - Total
43.5
The Jaguars are 4-1 ATS on the road this season and 6-2 ATS when favored.
At 3-10, the Bucs are the worst home team ATS since the beginning of last season.
Dallas Cowboys vs. Miami Dolphins Odds
- Spread
Dolphins -1.5 - Moneyline
Cowboys +102, Dolphins -122 - Total
51.5
The Cowboys are 7-0 ATS following an outright loss since the beginning of last season.
The Dolphins are 9-4 ATS since the beginning of last season when facing a top-10 defense.
Arizona Cardinals vs. Chicago Bears Odds
- Spread
Bears -4 - Moneyline
Cardinals +180, Bears -218 - Total
44
Unders are 6-1 in Arizona road games this season (0-7 when they play at home).
Overs are 14-6 in games following a Bears outright loss since the beginning of last season.
New England Patriots vs. Denver Broncos Odds
- Spread
Broncos -6.5 - Moneyline
Patriots +235, Broncos -290 - Total
34
The Pats are just 3-6 ATS since the beginning of last season when getting more than three points.
Since the beginning of last season, the Broncos are just 3-11 ATS when favored.
Las Vegas Raiders vs. Kansas City Chiefs Odds
- Spread
Chiefs -10 - Moneyline
Raiders +370, Chiefs -485 - Total
41.5
No team has been worse against the spread on the road since the beginning of last season than the Raiders (5-10).
Unders are 10-3-1 when the Chiefs play at home since the beginning of last season.
New York Giants vs. Philadelphia Eagles Odds
- Spread
Eagles -10.5 - Moneyline
Giants +440, Eagles -600 - Total
43
Unders are 18-7 since the beginning of last season when the Giants are an underdog.
The Eagles have outscored the Giants 94-33 over the past three meetings in Philadelphia.
Baltimore Ravens vs. San Francisco 49ers Odds
- Spread
49ers -5.5 - Moneyline
Ravens +195, 49ers -238 - Total
46
Unders are 3-1 this season when the Ravens play a top-10 passing offense.
The 49ers play a top-10 defense for the fourth time this season — they are 1-2 ATS in the previous three outings.
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