NFL Week 12 Picks, Predictions: Betting lines, odds, and scores

With Thanksgiving just a few days ago, we have a lot to be thankful for this week in the NFL. Let’s take a game-by-game look at our NFL Week 12 picks and predictions based on the betting lines and odds.

NFL Picks, Predictions for Week 12: Betting lines, odds, and scores

As there is every week, Week 12 features several games with playoff implications across the board. Many teams are looking to win convincingly and bounce back after bad losses, along with many teams on top that look to remain on top and cover convincingly. Take a look at the value in the betting lines and odds and bet accordingly.

Analysis of each game can be found below the table. Please note that most sportsbooks have taken the Broncos vs. Saints game off their books because of the situation with the Broncos quarterbacks. However, as of 10:15 PM on Saturday night (November 28), the odds below were still available on William Hill Sportsbook.

This table is best viewed in landscape mode if you are using a mobile device. 

TeamMoneylineSpreadOver/Under
Cincinnati Bengals42510.5 (-110)Over 42.5 (-110)
Miami Dolphins-550-10.5 (-110)Under 42.5 (-110)
TeamMoneylineSpreadOver/Under
Cleveland Browns1904.5 (-110)Over 53 (-110)
Tennessee Titans-220-4.5 (-110)Under 53 (-110)
TeamMoneylineSpreadOver/Under
Jacksonville Jaguars40010 (-110)Over 51 (-105)
Minnesota Vikings-500-10 (-110)Under 51 (-115)
TeamMoneylineSpreadOver/Under
Indianapolis Colts-170-3 (-115)Over 51 (-110)
Houston Texans1503 (-105)Under 51 (-110)
TeamMoneylineSpreadOver/Under
New Orleans Saints-145-3 (+105)Over 45.5 (-115)
Atlanta Falcons1253 (-125)Under 45.5 (-105)
TeamMoneylineSpreadOver/Under
Las Vegas Raiders-380-8 (-105)Over 46.5 (-110)
New York Jets3108 (-115)Under 46.5 (-110)
TeamMoneylineSpreadOver/Under
Detroit Lions1503 (+100)Over 45 (-110)
Chicago Bears-170-3 (-120)Under 45 (-110)
TeamMoneylineSpreadOver/Under
Los Angeles Rams-140-2.5 (-110)Over 48 (-110)
Arizona Cardinals1202.5 (-110)Under 48 (-110)
TeamMoneylineSpreadOver/Under
New York Giants425+11 (-110)Over 47 (-110)
Seattle Seahawks-550-11 (-110)Under 47 (-110)
TeamMoneylineSpreadOver/Under
New England Patriots105+1.5 (-10)Over 47 (-110)
Los Angeles Chargers-125-1.5 (-110)Under 47 (-110)
TeamMoneylineSpreadOver/Under
Philadelphia Eagles340+9 (-115)Over 49.5 (-110)
Green Bay Packers-420-9 (-105)Under 49.5 (-110)
TeamMoneylineSpreadOver/Under
Denver Broncos65013.5 (-115)Over 50.5 (-110)
Kansas City Chiefs-1000-13.5 (-105)Under 50.5 (-110)
TeamMoneylineSpreadOver/Under
Washington FootballN/AN/AN/A
Pittsburgh SteelersN/AN/AN/A
TeamMoneylineSpreadOver/Under
Buffalo Bills-1051 (-110)Over 47 (-110)
San Francisco 49ers-115-1 (-110)Under 47 (-110)
TeamMoneylineSpreadOver/Under
Dallas Cowboys2907.5 (-110)Over 44.5 (-110)
Baltimore Ravens-3507.5 (-110)Under 44.5 (-110)

NFL Week 12 Sunday Games | Betting lines and odds

Here are the NFL Week 12 picks, betting lines, and odds for Sunday’s games as of 10:15 PM ET on November 28.

Las Vegas Raiders (-3) at Atlanta Falcons

Time and Channel: 1:00 PM EST, CBS

The Raiders will have been disappointed that they could not pull out a win against the Chiefs, but taking it right to the final moments is extremely promising for this team’s future. Meanwhile, the Falcons were embarrassed by the New Orleans Saints in Week 11. The Raiders should be able to move the ball with ease and cover this Week 12 betting line.

NFL Week 12 Picks and Predictions: Raiders 35, Falcons 30

Carolina Panthers at Minnesota Vikings (-3.5)

Time and Channel: 1:00 PM EST, FOX

It was an impressive performance from the Panthers’ defense in Week 11, as they shut out the Detroit Lions to ensure their PJ Walker-led offense did not need to do more than the basics to get a win.

Related | NFL Picks, Predictions Against the Spread for Week 12

The Vikings were embarrassed last week by the Dallas Cowboys and will be looking to bounce back. The Panthers shut down the Lions run game in Week 11, but they will have their work cut out doing the same to Dalvin Cook. Look for the Vikings to control the time of possession on their way to a victory.

NFL Week 12 Picks and Predictions: Vikings 28, Panthers 18

Los Angeles Chargers at Buffalo Bills (-4.5)

Time and Channel: 1:00 PM EST, CBS

The Chargers have done nothing the easy way for as long as anyone can remember, but 2020 has been especially up and down. They made the Jets look competitive last week and will need to be significantly improved against a much better AFC East team. The Bills come off their bye, having lost to Arizona in a game that will have stung. They need to bounce back in this one, but it will not be easy.

NFL Week 12 Picks and Predictions: Bills 35, Chargers 33

Miami Dolphins (-6.5) at New York Jets

Time and Channel: 1:00 PM EST, CBS

The Dolphins look set to take on the Jets without quarterback Tua Tagovailoa, but Ryan Fitzpatrick should be more than capable of quarterbacking this team to victory. The Jets need to move the ball with consistency, which could be extremely tough against a very good Dolphins defense.

NFL Week 12 Picks and Predictions: Dolphins 24, Jets 13

Arizona Cardinals (-2) at New England Patriots

Time and Channel: 1:00 PM EST, FOX

The Patriots being underdogs at home is not something that we see very often, but it is no surprise the way they are playing this year. Their offense has failed to put together consistent performances, and their defense is significantly weakened.

If Kyler Murray is healthy, he should be able to have his way with this defense. The Patriots can take away one receiver, but the Cardinals have three they can attack teams with. The Patriots also do not have many players who can match Murray stride for stride when it comes to him scrambling.

NFL Week 12 Picks and Predictions: Cardinals 24, Patriots 21

Tennessee Titans at Indianapolis Colts (-3)

Time and Channel: 1:00 PM EST, CBS

It was a tight affair until the Titans unraveled down the stretch when these two teams last met in Week 10. Mike Vrabel is not the type of coach to allow sloppy mistakes regularly, and this team will be on a wave after beating the Ravens in overtime.

The Colts have been a frustrating team this season. Their defense has been superb and will stop the Titans from running away with the game. However, the offense has been extremely up and down and will be without Jonathan Taylor for this matchup.

NFL Week 12 Picks and Predictions: Titans 23, Colts 16

New York Giants (-6) at Cincinnati Bengals

Time and Channel: 1:00 EST, FOX

The matchup between the Bengals and Giants looked to be a perfect opportunity to compare Daniel Jones and Joe Burrow side by side. However, Burrow is now out for the year, and the Bengals are unlikely to generate much offense.

The Giants are in the thick of the NFC East race, and if they want to take advantage, this is a game they cannot afford to lose. Look for the Giants to do enough to get the win and cover this Week 12 betting line.

NFL Week 12 Picks and Predictions: Giants 28, Bengals 13

Cleveland Browns (-7) at Jacksonville Jaguars

Time and Channel: 1:00 PM EST, CBS

I am not sure at what point this Week 12 betting line would be considered too high. The Jacksonville Jaguars upset the odds in Week 1 of the NFL season, but since then, they have lost nine straight and enter Week 12 at 1-9. The Browns are starting to get rolling, especially on the ground. Both Kareem Hunt and Nick Chubb should have their way with the Jaguars’ defense in this matchup.

NFL Week 12 Picks and Predictions: Browns 24, Jaguars 20

New Orleans Saints (-14.5) at Denver Broncos

Time and Channel: 4:05 PM EST, FOX

The odds for this Week 12 NFL game have been a somewhat interesting topic, with Taysom Hill under center for the Saints. Can Hill be as efficient against the Broncos’ defense, or did the Falcons defense give us a false impression of what he can achieve as the starting QB of the Saints?

Related | NFL Week 11 Recap and Highlights: What Taysom Hill’s performance means

Denver upset the Dolphins last week, but the Broncos will be without all of their quarterbacks and rely on current practice squad wide receiver Kendall Hinton to be their quarterback. RB Royce Freeman is expected to be the emergency backup QB.

NFL Week 12 Picks and Predictions: Broncos 17, Saints 28

San Francisco 49ers at Los Angeles Rams (-6.5)

Time and Channel: 4:05 PM EST, FOX

Based on their recent form, the odds of this NFL Week 12 game seem to be correct. However, the Rams have already been beaten by the 49ers in 2020, and the 49ers are getting some pieces back this week. This game could be closer than many think, and I would not be shocked if the 49ers can put enough pressure on the Rams to come out on top.

NFL Week 12 Picks and Predictions: 49ers 27, Rams 24

Kansas City Chiefs (-3.5) at Tampa Bay Buccaneers

Time and Channel: 4:25 PM EST, CBS

This is a matchup between two teams that seem to be trending in different directions. The Chiefs are playing high-octane football, and their defense can step up when they need it.

Meanwhile, the Buccaneers defense was picked apart at times in Week 11 by Jared Goff. Their offense has also struggled in recent weeks. Unless the Buccaneers challenge the Chiefs receivers physically at the line, the Chiefs will run away with this one.

NFL Week 12 Scores and Predictions: Buccaneers 24, Chiefs 35

Sunday Night Football

Here are the NFL Week 12 picks, betting lines, and odds for Sunday Night Football as of 10:15 PM ET on November 28.

Chicago Bears at Green Bay Packers (-8.5)

Time and Channel: 8:20 PM EST, NBC

It is always an event when the Bears and Packers meet, but as these Week 12 NFL odds demonstrate, this game is not expected to be all that tough for the Packers. The Packers’ offense will struggle to move the ball efficiently, but on the other side, the Bears will likely struggle to exploit the Packers’ woeful run defense. Take the Packers to win and cover this Week 12 NFL betting line, but do not be surprised if the result is in doubt in a low-scoring affair entering the fourth quarter.

NFL Week 12 Scores and Predictions: Packers 21, Bears 10

Monday Night Football

Here are the NFL Week 12 picks, betting lines, and odds for Monday Night Football as of 10:15 PM ET on November 28.

Seattle Seahawks (-5.5) at Philadelphia Eagles

Time and Channel: 8:20 PM EST, ESPN

The Seahawks defense has largely been good for fixing struggling offenses, but is the Eagles offense beyond repair at this point?

Offensively, the Seahawks should have no major problems moving the ball. How close this game ends up will likely come down to what Carson Wentz can do as opposed to what we see from Russell Wilson.

NFL Week 12 Scores and Predictions: Seahawks 35, Eagles 23

Tuesday Night Football

Here are the NFL Week 12 picks, betting lines, and odds for Tuesday Night Football as of 10:15 PM ET on November 28.

Baltimore Ravens at Pittsburgh Steelers (-7.5)

Time and Channel: 8:00 PM EST, NBC

It has been a topsy-turvy week for both of these teams. They both will have got prepared mentally to play Thursday, only for the fixture to be moved. Now there are more disturbances, and who knows how these teams will be set mentally for this important clash.

The Ravens pushed Pittsburgh close in their last matchup, but Baltimore will likely be without Lamar Jackson and other members of their offense, while it appears likely the Steelers will be without James Conner. The potential loss of Jackson is huge, and if this game goes ahead, the Steelers should be clear favorites.

NFL Week 12 Picks and Predictions: Steelers 30, Ravens 16

Ben Rolfe is a Senior Managing Editor at Pro Football Network and is also a member of the Fantasy Sports Writers Association (FSWA). You can find him on Twitter @BenRolfePFN.

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