Week 17 betting lines for each NFL game are set . . . for now. As we know, things can and often will change. The following NFL betting odds are for picks against the spread, moneylines, and over/unders based on FanDuel Sportsbook.
Early NFL Week 17 Odds
Each week of the NFL season features the expected, the moderately unexpected, and the completely unexpected. When betting on point spreads and moneylines, we need to focus on the first two outcomes. With that in mind, here are each Week 16 game’s betting options.
Titans vs. Cowboys | Thursday
- Titans Odds: +10
- Cowboys Odds: -10
- Moneyline: +390 / -490
- Over/Under: 42.5
As I shared Monday morning in my Week 17 early picks and predictions column, it’s quite possible the Titans will “conserve” Derrick Henry for the win-or-go-home Week 18 faceoff versus the Jaguars. It might hinge on how effectively he and Malik Willis can guide their offense against the juggernaut Cowboys.
That makes these betting lines uniquely intriguing. What happens in the second half — namely, Henry’s indomitable presence — could hinge largely on how competitive this game is in the first half.
Giants vs. Colts | Sunday
- Giants Odds: -3.5
- Colts Odds: +3.5
- Moneyline: -190 / +160
- Over/Under: 40.5
The Giants are yielding the most rushing yards per carry. The Colts have scored the third-fewest points.
The Colts are obviously finished, and things might not look much brighter in 2023 if they don’t snag a top-10 QB in the NFL Draft to help right the ship. Next season also marks the final year in Jonathan Taylor’s and Michael Pittman Jr.’s rookie contracts. Yeah, a lot could change heading into 2024.
For now, the Giants are trying to lock down a surprising Wild Card berth, while the Colts are getting long looks at Nick Foles as a potential 2023 bridge QB, Zack Moss and Deon Jackson as potential backup RBs, and Jelani Woods as a possible franchise-caliber TE.
Eagles vs. Saints | Sunday
- Eagles Odds: -6.5
- Saints Odds: +6.5
- Moneyline: -295 / +245
- Over/Under: 44
This past Saturday, Gardner Minshew reminded the world that he deserves a long-term starting gig somewhere. Certainly not in Philly. Maybe Houston or Tennessee or Indy?
Regardless, Philly is looking to lock down the NFC’s No. 1 seed, which would give them an all-important first-round bye and similarly all-important home-field advantage until the Super Bowl.
The Saints, once again, will be without their three Week 1 starting WRs. Somehow, they can still reach the postseason with two wins and a little luck. They’ll need to get their best out of their up-and-down defense, Alvin Kamara, Taysom Hill, and Juwan Johnson.
Chiefs vs. Broncos | Sunday
- Chiefs Odds: -13.5
- Broncos Odds: +13.5
- Moneyline: -850 / +600
- Over/Under: 45
When these teams last met, the Chiefs nearly squandered a monster lead on three Patrick Mahomes interceptions. In fact, Denver was marching to take the lead late in the fourth quarter.
Not much has changed in that K.C. remains formidable, and Denver remains eminently beatable, largely because Russell Wilson looks like a backup quarterback. As I’ve written before, most high-performing dual-threat QBs have regressed sharply by their early 30s. Wilson is 34.
We have to move on from the notion that he’ll turn things around. Maybe next year, he’ll be middling. Perhaps a new Broncos head coach can fix him. But his greatest days seem firmly behind him.
Buccaneers vs. Panthers | Sunday
- Buccaneers Odds: -3
- Panthers Odds: +3
- Moneyline: -155 / +135
- Over/Under: 39.5
Heading into their last meeting, the 1-5 Panthers had just unloaded franchise RB Christian McCaffrey. It was the surest sign that they were all but throwing in the towel on 2022 and locking in draft picks for a continued rebuild. Then P.J. Walker, D’Onta Foreman, Chuba Hubbard, and an inspired defense shut down the Bucs 21-3.
The memory of that contest looms over this rematch, with the Panthers a win away from overtaking Tampa Bay in the NFC South. The point spread favors Tampa Bay because of where this game is being played. These are two evenly matched teams on opposite ends of the expectation spectrum — the Bucs vastly underperforming and the Panthers inconceivably overachieving.
Texans vs. Jaguars | Sunday
- Texans Odds: +4
- Jaguars Odds: -4
- Moneyline: +175 / -205
- Over/Under: 43.5
Back in October, I shared a statistical oddity about the one-win Texans — that they’d consistently trailed by a touchdown or less in the fourth quarter. In other words, they weren’t so much a terrible team; they were poor closers.
They continued this trend during the past three weeks against good-to-great competition, nearly toppling the Cowboys and 49ers before mounting a successful comeback against the Titans. Although the Jaguars are on a roll, the point spread suggests line setters trust that the battle-tested Texans will remain competitive.
Lions vs. Bears | Sunday
- Lions Odds: -5.5
- Lions Odds: +5.5
- Moneyline: -230 / +195
- Over/Under: 52
This a reminder that the Lions have reached the playoffs only three times this century, and they’ve won only one playoff game in their last 13 tries, dating back to 1963. This game could put them in the driver’s seat for a Wild Card berth.
No doubt, this team can win in a number of ways. They’re the most balanced Lions unit in many years, in direct contrast to the mostly one-dimensional Bears, which will need a championship-caliber performance from Justin Fields to send Detroit fans into a frenzy of heartache — or perhaps, a heartache-ing frenzy.
Patriots vs. Dolphins | Sunday
- Patriots Odds: -1.5
- Dolphins Odds: +1.5
- Moneyline: -120 / +100
- Over/Under: 42.5
Dolphin Nation right now is feeling about how Falcons fans felt in Super Bowl LI when Tom Brady and Danny Amendola cut Atlanta’s former 28-3 lead to 28-20 with under six minutes remaining. Sure, the Falcons still had the edge, but the sense of impending doom grew stronger.
With Tua Tagovailoa in the concussion protocol and with the Patriots’ QB situation potentially still in flux (i.e. we shouldn’t be surprised if Mac Jones gets benched if he starts poorly), the chaos and stakes (“chastakos“) surrounding this late-season matchup couldn’t be more intense.
Commanders vs. Browns | Sunday
- Commanders Odds: -2.5
- Browns Odds: +2.5
- Moneyline: -140 / +120
- Over/Under: 40.5
Timing isn’t everything, but it’s something.
If the Browns had won last week, they’d be 7-8 and in the thick of the Wild Card chase. Instead, Cleveland lost to New Orleans and is now mathematically eliminated from postseason contention.
As a result, will Deshaun Watson — the franchise’s $250 million (guaranteed) investment — even play? And if he does, will he be removed the first time he takes a hit? Because the Browns have nothing to gain and everything to lose by putting him in harm’s way.
Falcons vs. Cardinals | Sunday
- Falcons Odds: -3.5
- Cardinals Odds: +3.5
- Moneyline: -200 / +170
- Over/Under: 41
Presumably, Colt McCoy will return after missing Week 16. That should steady Arizona’s offense, particularly against an Atlanta defense that’s sub-par against the pass.
However, Atlanta remains in playoff contention, and in what might be an NFL first, they’re led at QB, RB, and WR by three rookies: Desmond Ridder, Tyler Allgeier, and Drake London.
That’s not to say other teams haven’t had rookies at each position. But the Falcons’ situation seems unique, as their postseason hopes hinge largely on how these three rookies fare in these final two games.
Raiders vs. 49ers | Saturday
- Raiders Odds: +5
- 49ers Odds: -5
- Moneyline: +200 / -240
- Over/Under: 44.5
Somehow, the Raiders are still hanging onto hope. One of the league’s oldest teams, with an offense designed to crush opposing defenses, is 2-9 when scoring less than 30 points. The 49ers have given up 30+ points only once all season.
San Francisco needs to win their final two games to have a shot at the NFC’s No. 2 seed — and a potential home game in the second round. Of course, that assumes the Vikings lose once.
So both teams have something to play for. But keep an eye on that Patriots-Dolphins game because if Miami prevails, it’s all over for Raider Nation, and that could impact personnel decisions — especially if the Raiders want to get a longer look at rookie Zamir White.
Seahawks vs. Jets | Sunday
- Seahawks Odds: -2.5
- Jets Odds: +2.5
- Moneyline: -135 / +115
- Over/Under: 42
Geno Smith versus the team that drafted him and then moved on from him after two seasons. We could debate whether Smith might have taken a significant Year 3 leap when the Jets added Brandon Marshall.
The point is that this game marks the nexus of Smith’s ascension as a true franchise quarterback. If the Seahawks win, they’ll still be squarely in playoff contention. If they lose, they’ll be 7-9, and Smith’s otherwise impressive age-32 campaign might raise questions about whether he’s the team’s long-term solution.
Packers vs. Vikings | Sunday
- Packers Odds: -3
- Vikings Odds: +3
- Moneyline: -175 / +150
- Over/Under: 47
When was the last time a below-.500 team was the favorite against a 12-3 team? Not sure, but I’ve never seen this before. It’s particularly unusual given the Vikings’ relative health among its star players.
That said, the point spread is the point spread, and the Packers are playing with confidence as their young receiving corps gels with their grizzled, chiseled QB. This will be a true battle in every sense.
Chargers vs. Rams | Sunday
- Chargers Odds: -6.5
- Rams Odds: +6.5
- Moneyline: -300 / +250
- Over/Under: 40.5
If the Chargers hadn’t dealt with significant injuries to their two best receivers, we might wonder if they’d be 11-4 or even 12-3 rather than “merely” 9-6. They’ve won three straight, and their defense has stepped up in tandem with a finally healthy offense.
Meanwhile, the Rams are on the verge of having the worst record of any defending Super Bowl champion. Yet they keep fighting, with Baker Mayfield playing for a starting job somewhere in 2023 and Cam Akers showing his team that they don’t need to sign a starter-caliber RB in the offseason.
Ravens vs. Steelers | Sunday
- Ravens Odds: -3
- Steelers Odds: +3
- Moneyline: +150 / -175
- Over/Under: 47
When these teams met in Week 18 last year, Ben Roethlisberger — in his final regular season game — “led” Pittsburgh to the victory, leapfrogging Baltimore for the final Wild Card spot.
This year, Pittsburgh’s averaging fewer points per game, but they’re also giving up fewer points per game. And we have to believe rookies Kenny Pickett and George Pickens are only getting better.
With Baltimore limping into the postseason, they’re simply trying not to suffer any more devastating injuries. The Steelers are playing with everything to win and everything to lose.
Bengals vs. Bills | Monday
- Bengals Odds: +1.5
- Bills Odds: -1.5
- Moneyline: +100 / -120
- Over/Under: 49.5
Perhaps a preview of the AFC championship game. The last time these teams met was in 2019, Buffalo’s top wideouts were Cole Beasley and John Brown, while Cincy’s were Tyler Boyd and Auden Tate. Frank Gore led the Bills’ rushing attack, while Andy Dalton guided the Bengals’ passing game.
Cincinnati won only two games that year, while the Bills’ dynasty began in season No. 2 for Josh Allen.
If you’re looking for a heavyweight battle, this is it. The betting lines suggest it will be high-scoring and close. It surely has the potential epic, with a potential No. 1 seed on the line.