Patrick Mahomes Fantasy Hub: Week 12 Injury Update, Start ‘Em/Sit ‘Em Advice, Points Projection, and Weather Impact

Here's this week's fantasy football outlook for Patrick Mahomes, including injury updates, start-sit advice, points projection, and weather impact.

The Kansas City Chiefs will host the Indianapolis Colts in Week 12. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, specifically regarding QB Patrick Mahomes.

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Is Patrick Mahomes Playing in Week 12?

Mahomes is not on the injury report and barring a surprise, he is expected to play.

We’ll continue to monitor the Chiefs’ injury report leading up to kickoff for any changes. You can also visit and bookmark our Fantasy News Tracker for the latest updates.

Should You Start or Sit Mahomes in Week 12?

It’s been a wild ride for those with Mahomes rostered this season. Over the last two games, on the heels of three straight 3-TD games, he’s totaled one passing touchdown and eight rushing yards.

In the first two months of this season, that was one quarter’s worth of production.

He now has six games this season with one or fewer pass TDs, as this season truly has been a boom/bust one for #15. Mahomes was one of nine throwing deep last week and hasn’t had a long touchdown pass in six straight games.

The Colts have allowed 20+ fantasy points to Bo Nix, Matthew Stafford, Jacoby Brissett, and Justin Herbert this year. Their offense puts their defense in a position to face aggressive offenses regularly, and if the Chiefs can execute that plan, Mahomes can post a top-5 performance.

But could this be a grind-it-out Jonathan Taylor game off the bye?

The range of outcomes is wide for Mahomes, and while I’m comfortable in ranking him as my QB6, he’s sitting at the top of a tier that extends all the way down to QB12.

Are you looking for start/sit advice for other players in your lineup? Read our Fantasy Football Start ‘Em, Sit ‘Em Cheat Sheet.

Mahomes’ Fantasy Points Projection in Week 12

Mahomes is projected to score 20.4 fantasy points in PPR formats.

We project Mahomes to throw for 266 yards and 1.9 passing touchdowns with 0.7 interceptions. Mahomes could also add 21 rushing yards and 0.1 rushing touchdowns on the ground.

Check out the free PFSN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.

Week 12 Weather Impact: Colts at Chiefs

The forecast for kickoff is 49 degrees Fahrenheit with 2 mph winds. These are ideal conditions for fantasy production.

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