Injuries are a part of football. Thankfully, there weren’t too many catastrophic injuries in Week 1, although several teams (especially the San Francisco 49ers) would disagree with that sentence.
Below are the injuries that could impact fantasy football in Week 2.
George Kittle, TE, San Francisco 49ers | Out
The 49ers officially placed George Kittle on injured reserve because of his hamstring injury, guaranteeing that he will miss at least the next four games.
49ers placing TE George Kittle (hamstring) on IR. (via @tompelissero) pic.twitter.com/hIAhkjTSIk
— NFL (@NFL) September 9, 2025
San Francisco doesn’t have another tight end who can come close to Kittle’s production, so they will need players like Ricky Pearsall and Jauan Jennings (more on him later) to step up in his absence. Expect both receivers (plus running back Christian McCaffrey) to see even more volume in the short term.
Isaiah Likely, TE, Baltimore Ravens | Out
Isaiah Likely was ruled out for Week 2’s matchup against the Browns as he continues to recover from his foot injury. DeAndre Hopkins and Mark Andrews are the biggest beneficiaries of his absence, as they have taken on increased roles in the red zone.
Brock Purdy, QB, San Francisco 49ers | Out
One of the bigger injury surprises coming out of Week 1 was Brock Purdy. The veteran quarterback didn’t miss a snap in the team’s opening win against the Seahawks, but popped up on the injury report Monday with a toe and shoulder injury.
Purdy was officially ruled out for Week 2’s game against the Saints on Friday. It will likely be the first of several games missed by the veteran signal caller.
49ers QB Brock Purdy will miss 2-5 weeks with a form of turf toe. (via @rapsheet) pic.twitter.com/CcuyQngF6H
— NFL (@NFL) September 11, 2025
If Purdy is unable to play, Mac Jones would start for the 49ers against the New Orleans Saints. In 2024, the veteran quarterback completed 65.3% of his passes for 1,672 yards, eight touchdowns, and eight interceptions in 10 games with the Jaguars. He averaged just 9.6 fantasy points per game during that time.
Darren Waller, TE, Miami Dolphins | Out
A hip injury kept Darren Waller out of Miami’s Week 1 game against the Colts. Waller did not participate in practice on 9/10 or 9/11, which means it is a long-shot to expect him to play in Week 2.
Will Shipley, RB, Philadelphia Eagles | Out
Will Shipley was used in the first half of the Philadelphia Eagles’ win over the Dallas Cowboys as a breather back for Saquon Barkley. He racked up three carries for 26 yards (all in the first half) before exiting with a rib injury.
Shipley was officially ruled out on Friday. Barkley will continue to dominate touches in the backfield, but AJ Dillon and new running back Tank Bigsby could be used to spell him for the occiasional drive throughout the game. Neither have much standalone fantasy value.
Dallas Goedert, TE, Philadelphia Eagles | Out
Dallas Goedert led the Eagles in receptions against the Dallas Cowboys in Week 1. Unfortunately, the veteran tight end suffered a knee sprain in that contest. It is not expected to be a long-term issue.
Goedert was listed as a limited practice participant on Tuesday before not practicing on Wednesday or Thursday. He was officially ruled out on Friday due to his knee injury.
Jahan Dotson becomes an interesting waiver addition against with Goedert ruled out after catching three targets for 59 yards in Week 1.
Xavier Worthy, WR, Kansas City Chiefs | Doubtful
The only clarity we have gotten on Xavier Worthy’s shoulder injury is that he is day-to-day. That said, it feels like a long shot that the second-year receiver will be ready to play in Week 2 after dislocating his shoulder colliding with Travis Kelce in Week 1. Worthy did not practice on Wednesday (9/10).
Worthy did return to the practice field on Thursday, but his status for Week 2 is up in the air. Still, this is a positive development that suggests that any absence from the shoulder injury will not be long-term at this time.
The biggest beneficiaries of Worthy being out would be veteran receivers Hollywood Brown and Tyquan Thornton, along with tight end Travis Kelce.
Chris Godwin, WR, Tampa Bay Buccaneers | Doubtful
The Tampa Bay Buccaneers have maintained that the goal for Chris Godwin is a debut in Week 5 at the earliest. He enters Week 2 with a doubtful designation, but is very unlikely to see the field.
Christian Kirk, WR, Houston Texans | Questionable
Christian Kirk was a late addition to the injury report and ultimately missed Week 1 with a hamstring injury. The Houston Texans’ offense struggled mainly due to poor offensive line play, which Kirk could help address with his route-running ability.
Kirk did not participate in practice in Week 2, setting him up to miss his second consecutive game. Houston struggled to find another target earner outside of Nico Collins in Week 1. Expect Dalton Schutlz (five targets, three receptions, 28 receiving yards) to continue to be a factor in the middle of the field.
Brock Bowers, TE, Las Vegas Raiders | Questionable
Brock Bowers was knocked out of the Las Vegas Raiders’ first game against the Patriots with a knee injury. After the match, Bowers downplayed the severity of the injury, stating he was held out as a precaution.
#Raiders Brock Bowers – Video suggests MCL sprain
Meniscus, ACL possible but suspect they’re less likely here
If MCL alone, absence would typically be short-term pic.twitter.com/wBWSAtw3eU
— Deepak Chona, MD. SMA (@SportMDAnalysis) September 7, 2025
Bowers did not participate in practice on Thursday or Friday, which makes his playing status a long shot heading into Week 2, although he does benefit from a Monday night game. Adding Michael Mayer on waivers is a must for teams with Bowers.
Best case scenario, Bowers is active on Monday and there are no issues. Worst case scenario you get his replacement who had a solid showing in Week 1 (four receptions for 38 yards). Either way, fantasy managers will need to monitor Bowers’ status closely and may need to make a tough decision on Sunday.
Jauan Jennings, WR, San Francisco 49ers | Questionable
It wasn’t all bad injury news for the 49ers. All of the imaging on Jennings’ shoulder injury has returned positive, giving him a real chance to play in Week 2. The 49ers will need all the help they can get in the passing attack with Aiyuk and Kittle confirmed as out.
Jennings did not participate in Wednesday’s or Thursday’s practices, but was finally upgraded to a limited particpant on Friday. He enters Week 2 with a questionable designation.
Mason Taylor, TE, New York Jets | Questionable
Mason Taylor was viewed as a late-round tight end target due to a lack of competition with the Jets. He caught just one pass for 20 yards in his first career game before suffering an ankle injury. He did not practice on Wednesday, but was a full participant by Friday’s practice.
Taylor is listed as questionable heading into Week 2, but should be active barring an unforseen setback in the next 24 hours.
Drake London, WR, Atlanta Falcons
Drake London was removed from the Falcons’ injury report on Friday, clearing the runway for him to participate in Week 2’s game against the Minnesota Vikings. He suffered a shoulder injury in Week 1, but was a limited participant in practice throughout the week.
Darnell Mooney, WR, Atlanta Falcons
Darnell Mooney missed Week 1 with a shoulder injury, but was close to playing. He is set to make his 2025 debut against the Vikings in Week 2.
Evan Engram, TE, Denver Broncos
Evan Engram was off to a quiet start in his first game with the Broncos (four targets, three receptions, 21 receiving yards) before a calf injury ended his day early.
Calf injuries are notoriously fickle, so it wouldn’t be shocking if the veteran tight end missed at least one week, if not more. In that case, players like Pat Bryant or Troy Franklin would see their workload increase.
Engram logged a limited practice on 9/10 and was a full participant on Thursday (9/11) and Friday (9/12). He was officially removed from the injury report on Friday and is good to go in Week 2’s matchup against the Colts.
James Cook, RB, Buffalo Bills
A surprising name on the injury report on Wednesday was Buffalo Bills running back James Cook. Cook was a limited participant due to a hamstring injury after a strong Week 1 performance against the Baltimore Ravens (13 carries for 44 yards and a touchdown with five receptions for 58 yards).
Cook returned to practice on Thursday (9/11) and does not carry an injury designation into Week 2’s matchup against the New York Jets.
Jaylen Waddle, WR, Miami Dolphins
Jaylen Waddle was briefly out of the game against the Colts in Week 1 due to a shoulder injury. He did return to the contest. Due to the injury, the veteran receiver was listed as a limited participant in practice on 9/10 and 9/11.
Waddle was removed from the injury report on Friday and is set to play against the Patriots in Week 2.
Kayshon Boutte, WR, New England Patriots
Kayshon Boutte was one of the biggest surprises of Week 1, catching six of eight targets for 103 yards against the Las Vegas Raiders. Boutte was on the injury report Wednesday and Thursday as a limited participant due to a shoulder injury.
Boutte does not appear on the Patriots final injury report.
Malik Nabers, WR, New York Giants
Malik Nabers was limited in practice on Wednesday due to his back injury. Nabers logged a 94% snap share in Week 1, catching five of 12 targets for 71 yards. Expect him to remain a fixture on injury reports for the foreseeable future.
Nabers is not listed on the Giants’ final injury report and is good to go for Week 2.
