Kyler Murray Fantasy Hub: Week 6 Injury Update, Start ‘Em/Sit ‘Em Advice, Points Projection, and Weather Impact

Here's this week's fantasy football outlook for Kyler Murray, including injury updates, start-sit advice, points projection, and weather impact.

The Arizona Cardinals (2-3) will visit the Indianapolis Colts (4-1) in Week 6. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, specifically regarding QB Kyler Murray.

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Is Kyler Murray Playing in Week 6?

Update: Murray will not play in Week 6. Jacoby Brissett takes over starting duties for Arizona.

Murray (foot) is questionable for Sunday’s game against the Colts. Check back here for more updates as we get closer to game time.

We’ll continue to monitor the Cardinals’ injury report leading up to kickoff for any changes. You can also visit and bookmark our Fantasy News Tracker for the latest updates.

Should You Start or Sit Kyler Murray in Week 6?

We are five weeks into this season and I’m not the least bit confident that we know what we are going to get in this spot.

On one hand, the Colts have crippled poor opposing quarterbacks (Tua Tagovailoa, Cam Newton, and Geno Smith are of no real interest to us and they averaged 7.7 fantasy points against Indy), but on the other, we’ve seen Bo Nix (20.2) and Matthew Stafford (27.4) have success.

Which bucket does Kyler Murray get placed into?

Your instinct wants to say the latter, and the numbers suggest the latter.

Arizona has already played New Orleans, Carolina, and Tennessee, all of whom figure to be in the mix for the top overall pick this spring.

Murray’s next finish for a week better than QB12 will be his first.

“Outlook not so clear”.

He’s reached 25 rushing yards in every game this season and has a 30+ yard completion in four of five. That potential is something we are aware of and that’s why he’s in the QB1 mix, but I can’t just erase what we’ve seen thus far, and that is why he’s my QB2 in this game and also checks in behind a pocket-locked Matthew Stafford (at BAL).

Are you looking for start/sit advice for other players in your lineup? Read our Fantasy Football Start ‘Em, Sit ‘Em Cheat Sheet.

Murray’s Fantasy Points Projection in Week 6

Murray is projected to score 18.2 fantasy points in PPR formats.

We project Murray to throw for 220 yards and 1.3 passing touchdowns with 0.6 interceptions. Murray could also add 31 rushing yards and 0.3 rushing touchdowns on the ground.

Check out the free PFSN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.

Week 6 Weather Impact: Cardinals at Colts

Since the Colts play in a dome, there is no weather impact for this Week 6 matchup. Temperatures will be a comfortable 72 degrees Fahrenheit with no wind.

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