Christian McCaffrey Fantasy Hub: Week 6 Injury Update, Start ‘Em/Sit ‘Em Advice, Points Projection, and Weather Impact

Here's this week's fantasy football outlook for Christian McCaffrey, including injury updates, start-sit advice, points projection, and weather impact.

The San Francisco 49ers (4-1) will visit the Tampa Bay Buccaneers (4-1) in Week 6. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, specifically regarding RB Christian McCaffrey.

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Is Christian McCaffrey Playing in Week 6?

McCaffrey is not on the injury report and barring a surprise, he is expected to play.

We’ll continue to monitor the 49ers’ injury report leading up to kickoff for any changes. You can also visit and bookmark our Fantasy News Tracker for the latest updates.

Should You Start or Sit Christian McCaffrey in Week 6?

Great players make the great performances feel ordinary, and we entered that point with Christian McCaffrey a while ago.

Through five weeks, he’s pacing for 310 carries, 133 catches, and 2,275 yards from scrimmage.

Let me contextualize that for you. Only three players had that many carries in 2021, and only six players in NFL history have ever had that many catches in a season (PPR floor this season: 22.7 points).

Those stats are remarkable by themselves, but he hasn’t even gotten things going on the ground. He doesn’t yet have a run gaining more than 15 yards or a game with 70 rushing yards (3.1 yards per carry). What happens if he trends toward his career rates in that regard?

He has a touchdown reception in three of the past four weeks, Thursday night’s edition coming with him lined up as a slot receiver and making light work of the poor linebacker asked to square up with him.

I don’t care who is or isn’t healthy for the 49ers. I don’t care who they are facing. To be honest, I don’t care if CMC is down a hamstring or up to three fingers.

If he’s on the field, I’m expecting elite production, and that’s the end of the discussion.

Are you looking for start/sit advice for other players in your lineup? Read our Fantasy Football Start ‘Em, Sit ‘Em Cheat Sheet.

McCaffrey’s Fantasy Points Projection in Week 6

McCaffrey is projected to score 25.4 fantasy points in PPR formats.

We project McCaffrey to rush for 91 yards and 0.5 rushing touchdowns, while adding 6 receptions for 55 receiving yards and 0.3 receiving touchdowns.

Check out the free PFSN Fantasy Start-Sit Optimizer for the latest projections and advice for your lineups this week.

Week 6 Weather Impact: 49ers at Buccaneers

The forecast for kickoff is 85 degrees Fahrenheit with 17 mph winds. Moderate winds may affect deep passes and field goal attempts.

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