College Football Predictions Week 6: Projecting Every Game as Saturday Shocks Set to Shake up Playoff Picture

There are multiple high-profile matchups in Week 6, and our college football predictions forecast the winner of every game on a stacked Saturday.

Our college football predictions for Week 6, compiled using the PFSN College Football Playoff Predictor, provide the answer to the question of who is winning in a packed slate of games!

Don’t like these results? You can predict a conference, every game, or simulate the entire season to discover which 12 teams will make the College Football Playoff. Get started right now!

PFSN 2026-2027 CFB Playoff Predictor
Play out the entire college football season with PFSN's CFB Playoff Predictor to see what it means for conference standings and the CFB playoffs!

Kentucky vs. Georgia Prediction

  • Prediction: Kentucky 21, Georgia 37
  • Date: Saturday, October 4, Noon ET
  • TV Channel: ABC

Iowa State vs. Cincinnati Prediction

  • Prediction: Iowa State 24, Cincinnati 14
  • Date: Saturday, October 4, Noon ET
  • TV Channel: ESPN2

Wisconsin vs. Michigan Prediction

  • Prediction: Wisconsin 17, Michigan 27
  • Date: Saturday, October 4, Noon ET
  • TV Channel: FOX

Illinois vs. Purdue Prediction

  • Prediction: Illinois 27, Purdue 13
  • Date: Saturday, October 4, Noon ET
  • TV Channel: BTN

Boston College vs. Pittsburgh Prediction

  • Prediction: Boston College 30, Pittsburgh 17
  • Date: Saturday, October 4, Noon ET
  • TV Channel: ACC Network

Clemson vs. North Carolina Prediction

  • Prediction: Clemson 33, North Carolina 14
  • Date: Saturday, October 4, Noon ET
  • TV Channel: ESPN

Kansas State vs. Baylor Prediction

  • Prediction: Kansas State 17, Baylor 37
  • Date: Saturday, October 4, Noon ET
  • TV Channel: ESPN+

Air Force vs. Navy Prediction

  • Prediction: Air Force 21, Navy 31
  • Date: Saturday, October 4, Noon ET
  • TV Channel: CBS

Army vs. UAB Prediction

  • Prediction: Army 31, UAB 17
  • Date: Saturday, October 4, Noon ET
  • TV Channel: ESPNU

Ohio vs. Ball State Prediction

  • Prediction: Ohio 23, Ball State 10
  • Date: Saturday, October 4, Noon ET
  • TV Channel: CBSSN

Wake Forest vs. Virginia Tech Prediction

  • Prediction: Wake Forest 27, Virginia Tech 15
  • Date: Saturday, October 4, 1 p.m. ET
  • TV Channel: The CW Network

UTSA vs. Temple Prediction

  • Prediction: UTSA 40, Temple 27
  • Date: Saturday, October 4, 1 p.m. ET
  • TV Channel: ESPN+

Campbell vs. NC State Prediction

  • Prediction: Campbell 10, NC State 35
  • Date: Saturday, October 4, 2 p.m. ET
  • TV Channel: ESPN+

Western Michigan vs. UMass Prediction

  • Prediction: Western Michigan 17, UMass 10
  • Date: Saturday, October 4, 2:30 p.m. ET
  • TV Channel: ESPN+

Oklahoma State vs. Arizona Prediction

  • Prediction: Oklahoma State 10, Arizona 23
  • Date: Saturday, October 4, 3 p.m. ET
  • TV Channel: TNT

Penn State vs. UCLA Prediction

  • Prediction: Penn State 20, UCLA 17
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: CBS

Texas vs. Florida Prediction

  • Prediction: Texas 30, Florida 17
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ESPN

Vanderbilt vs. Alabama Prediction

  • Prediction: Vanderbilt 13, Alabama 20
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ABC

Boise State vs. Notre Dame Prediction

  • Prediction: Boise State 27, Notre Dame 40
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: NBC

Virginia vs. Louisville Prediction

  • Prediction: Virginia 30, Louisville 27
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ESPN2

Washington vs. Maryland Prediction

  • Prediction: Washington 13, Maryland 23
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: BTN

Louisiana-Monroe vs. Northwestern Prediction

  • Prediction: Louisiana-Monroe 27, Northwestern 10
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: BTN

Oregon State vs. Appalachian State Prediction

  • Prediction: Oregon State 24, Appalachian State 27
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ESPN+

Syracuse vs. SMU Prediction

  • Prediction: Syracuse 33, SMU 30
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ACC Network

Florida International vs. UConn Prediction

  • Prediction: Florida International 21, UConn 40
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: CBSSN

James Madison vs. Georgia State Prediction

  • Prediction: James Madison 37, Georgia State 21
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ESPN+

Central Michigan vs. Akron Prediction

  • Prediction: Central Michigan 35, Akron 21
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ESPN+

Eastern Michigan vs. Buffalo Prediction

  • Prediction: Eastern Michigan 17, Buffalo 31
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ESPN+

Miami (OH) vs. Northern Illinois Prediction

  • Prediction: Miami (OH) 10, Northern Illinois 27
  • Date: Saturday, October 4, 3:30 p.m. ET
  • TV Channel: ESPN+

Kent State vs. Oklahoma Prediction

  • Prediction: Kent State 10, Oklahoma 33
  • Date: Saturday, October 4, 4 p.m. ET
  • TV Channel: SEC Network

Michigan State vs. Nebraska Prediction

  • Prediction: Michigan State 17, Nebraska 30
  • Date: Saturday, October 4, 4 p.m. ET
  • TV Channel: FS1

Texas State vs. Arkansas State Prediction

  • Prediction: Texas State 40, Arkansas State 23
  • Date: Saturday, October 4, 4 p.m. ET
  • TV Channel: ESPNU

Coastal Carolina vs. Old Dominion Prediction

  • Prediction: Coastal Carolina 17, Old Dominion 30
  • Date: Saturday, October 4, 6 p.m. ET
  • TV Channel: ESPN+

Texas Tech vs. Houston Prediction

  • Prediction: Texas Tech 27, Houston 10
  • Date: Saturday, October 4, 7 p.m. ET
  • TV Channel: ESPN

UNLV vs. Wyoming Prediction

  • Prediction: UNLV 40, Wyoming 27
  • Date: Saturday, October 4, 7 p.m. ET
  • TV Channel: CBSSN

South Alabama vs. Troy Prediction

  • Prediction: South Alabama 35, Troy 21
  • Date: Saturday, October 4, 7 p.m. ET
  • TV Channel: ESPN+

Florida Atlantic vs. Rice Prediction

  • Prediction: Florida Atlantic 10, Rice 24
  • Date: Saturday, October 4, 7 p.m. ET
  • TV Channel: ESPN+

Minnesota vs. Ohio State Prediction

  • Prediction: Minnesota 24, Ohio State 37
  • Date: Saturday, October 4, 7:30 p.m. ET
  • TV Channel: NBC

Miami (FL) vs. Florida State Prediction

  • Prediction: Miami (FL) 14, Florida State 30
  • Date: Saturday, October 4, 7:30 p.m. ET
  • TV Channel: ABC

Mississippi State vs. Texas A&M Prediction

  • Prediction: Mississippi State 13, Texas A&M 27
  • Date: Saturday, October 4, 7:30 p.m. ET
  • TV Channel: SEC Network

Colorado vs. TCU Prediction

  • Prediction: Colorado 13, TCU 30
  • Date: Saturday, October 4, 7:30 p.m. ET
  • TV Channel: FOX

Kansas vs. UCF Prediction

  • Prediction: Kansas 40, UCF 24
  • Date: Saturday, October 4, 7:30 p.m. ET
  • TV Channel: ESPN2

Tulsa vs. Memphis Prediction

  • Prediction: Tulsa 17, Memphis 35
  • Date: Saturday, October 4, 8 p.m. ET
  • TV Channel: ESPNU

Duke vs. California Prediction

  • Prediction: Duke 30, California 13
  • Date: Saturday, October 4, 10:30 p.m. ET
  • TV Channel: ESPN

Nevada vs. Fresno State Prediction

  • Prediction: Nevada 17, Fresno State 30
  • Date: Saturday, October 4, 10:30 p.m. ET
  • TV Channel: CBSSN

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