College Football Predictions Week 5: Who is Set to Shock In Stacked Slate?

The Week 5 slate is stacked, but who is set to pull off a major shock on Saturday? Our college football predictions provide forecasts for every game!

September 27, 2025 | 10:20 AM EDT

Our college football predictions for Week 5, compiled using the PFSN College Football Playoff Predictor, provide the answer to the question of who is winning in a packed slate of games!

Don’t like these results? You can predict a conference, every game, or simulate the entire season to discover which 12 teams will make the College Football Playoff. Get started right now!

Georgia Tech vs. Wake Forest Prediction

Prediction: Georgia Tech 30, Wake Forest 21
Date: Saturday, Sept. 27, Noon ET
TV Channel: ESPN

USC vs. Illinois Prediction

Prediction: USC 35, Illinois 21
Date: Saturday, Sept. 27, Noon ET
TV Channel: FOX

Notre Dame vs. Arkansas Prediction

Prediction: Notre Dame 24, Arkansas 13
Date: Saturday, Sept. 27, Noon ET
TV Channel: ABC

Rutgers vs. Minnesota Prediction

Prediction: Rutgers 20, Minnesota 10
Date: Saturday, Sept. 27, Noon ET
TV Channel: BTN

Duke vs. Syracuse Prediction

Prediction: Duke 27, Syracuse 37
Date: Saturday, Sept. 27, Noon ET
TV Channel: ACC Network

Louisville vs. Pittsburgh Prediction

Prediction: Louisville 27, Pittsburgh 14
Date: Saturday, Sept. 27, Noon ET
TV Channel: ESPN2

Cincinnati vs. Kansas Prediction

Prediction: Cincinnati 24, Kansas 34
Date: Saturday, Sept. 27, Noon ET
TV Channel: TNT

UCF vs. Kansas State Prediction

Prediction: UCF 31, Kansas State 17
Date: Saturday, Sept. 27, Noon ET
TV Channel: FS1

South Alabama vs. North Texas Prediction

Prediction: South Alabama 28, North Texas 35
Date: Saturday, Sept. 27, Noon ET
TV Channel: ESPNU

Bowling Green vs. Ohio Prediction

Prediction: Bowling Green 21, Ohio 34
Date: Saturday, Sept. 27, Noon ET
TV Channel: CBSSN

Utah State vs. Vanderbilt Prediction

Prediction: Utah State 10, Vanderbilt 35
Date: Saturday, Sept. 27, 12:45 p.m. ET
TV Channel: SEC Network

Eastern Michigan vs. Central Michigan Prediction

Prediction: Eastern Michigan 21, Central Michigan 40
Date: Saturday, Sept. 27, 1 p.m. ET
TV Channel: ESPN+

Georgia Southern vs. James Madison Prediction

Prediction: Georgia Southern 13, James Madison 27
Date: Saturday, Sept. 27, 1:30 p.m. ET
TV Channel: ESPN+

Arkansas State vs. Louisiana-Monroe Prediction

Prediction: Arkansas State 10, Louisiana-Monroe 27
Date: Saturday, Sept. 27, 3 p.m. ET
TV Channel: ESPN+

Ohio State vs. Washington Prediction

Prediction: Ohio State 27, Washington 24
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: CBS

LSU vs. Ole Miss Prediction

Prediction: LSU 23, Ole Miss 34
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ABC

Auburn vs. Texas A&M Prediction

Prediction: Auburn 17, Texas A&M 31
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ESPN

Indiana vs. Iowa Prediction

Prediction: Indiana 40, Iowa 27
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: Peacock

UCLA vs. Northwestern Prediction

Prediction: UCLA 21, Northwestern 23
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: BTN

California vs. Boston College Prediction

Prediction: California 10, Boston College 24
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ACC Network

Baylor vs. Oklahoma State Prediction

Prediction: Baylor 31, Oklahoma State 17
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ESPN2

Utah vs. West Virginia Prediction

Prediction: Utah 30, West Virginia 21
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: FOX

UConn vs. Buffalo Prediction

Prediction: UConn 27, Buffalo 40
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ESPN+

San Diego State vs. Northern Illinois Prediction

Prediction: San Diego State 35, Northern Illinois 21
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ESPN+

Rice vs. Navy Prediction

Prediction: Rice 24, Navy 35
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: CBSSN

Akron vs. Toledo Prediction

Prediction: Akron 10, Toledo 24
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ESPN+

Lindenwood vs. Miami (OH) Prediction

Prediction: Lindenwood 21, Miami (OH) 27
Date: Saturday, Sept. 27, 3:30 p.m. ET
TV Channel: ESPN+

New Mexico State vs. New Mexico Prediction

Prediction: New Mexico State 21, New Mexico 37
Date: Saturday, Sept. 27, 9:00 p.m. ET
TV Channel: Mountain West Network

Tulane vs. Tulsa Prediction

Prediction: Tulane 35, Tulsa 17
Date: Saturday, Sept. 27, 4 p.m. ET
TV Channel: ESPNU

Hawaii vs. Air Force Prediction

Prediction: Hawaii 14, Air Force 30
Date: Saturday, Sept. 27, 4:10 p.m. ET
TV Channel: FS1

Tennessee vs. Mississippi State Prediction

Prediction: Tennessee 24, Mississippi State 10
Date: Saturday, Sept. 27, 4:15 p.m. ET
TV Channel: SEC Network

Middle Tennessee vs. Kennesaw State Prediction

Prediction: Middle Tennessee 21, Kennesaw State 24
Date: Saturday, Sept. 27, 6 p.m. ET
TV Channel: ESPN+

Liberty vs. Old Dominion Prediction

Prediction: Liberty 24, Old Dominion 37
Date: Saturday, Sept. 27, 6 p.m. ET
TV Channel: ESPN+

Rhode Island vs. Western Michigan Prediction

Prediction: Rhode Island 20, Western Michigan 40
Date: Saturday, Sept. 27, 6:30 p.m. ET
TV Channel: ESPN+

Arizona vs. Iowa State Prediction

Prediction: Arizona 10, Iowa State 30
Date: Saturday, Sept. 27, 7 p.m. ET
TV Channel: ESPN

Virginia Tech vs. NC State Prediction

Prediction: Virginia Tech 21, NC State 35
Date: Saturday, Sept. 27, 7 p.m. ET
TV Channel: The CW Network

Jacksonville State vs. Southern Miss Prediction

Prediction: Jacksonville State 37, Southern Miss 24
Date: Saturday, Sept. 27, 7 p.m. ET
TV Channel: ESPN+

Western Kentucky vs. Missouri State Prediction

Prediction: Western Kentucky 37, Missouri State 21
Date: Saturday, Sept. 27, 7 p.m. ET
TV Channel: ESPN+

Memphis vs. Florida Atlantic Prediction

Prediction: Memphis 31, Florida Atlantic 23
Date: Saturday, Sept. 27, 7 p.m. ET
TV Channel: ESPN2

Oregon vs. Penn State Prediction

Prediction: Oregon 38, Penn State 30
Date: Saturday, Sept. 27, 7:30 p.m. ET
TV Channel: NBC

Alabama vs. Georgia Prediction

Prediction: Alabama 17, Georgia 33
Date: Saturday, Sept. 27, 7:30 p.m. ET
TV Channel: ABC

UMass vs. Missouri Prediction

Prediction: UMass 19, Missouri 40
Date: Saturday, Sept. 27, 7:30 p.m. ET
TV Channel: ESPNU

Washington State vs. Colorado State Prediction

Prediction: Washington State 23, Colorado State 33
Date: Saturday, Sept. 27, 7:30 p.m. ET
TV Channel: CBSSN

San José State vs. Stanford Prediction

Prediction: San Jose State 37, Stanford 20
Date: Saturday, Sept. 27, 7:30 p.m. ET
TV Channel: ACC Network

Appalachian State vs. Boise State Prediction

Prediction: Appalachian State 17, Boise State 33
Date: Saturday, Sept. 27, 7:30 p.m. ET
TV Channel: FS1

Kentucky vs. South Carolina Prediction

Prediction: Kentucky 17, South Carolina 30
Date: Saturday, Sept. 27, 7:45 p.m. ET
TV Channel: SEC Network

Marshall vs. Louisiana Prediction

Prediction: Marshall 24, Louisiana 31
Date: Saturday, Sept. 27, 8 p.m. ET
TV Channel: ESPN+

Louisiana Tech vs. UTEP Prediction

Prediction: Louisiana Tech 33, UTEP 17
Date: Saturday, Sept. 27, 9 p.m. ET
TV Channel: ESPN+

BYU vs. Colorado Prediction

Prediction: BYU 31, Colorado 21
Date: Saturday, Sept. 27, 10:15 p.m. ET
TV Channel: ESPN

Written by Oliver Hodgkinson