The Arizona Cardinals and Dallas Cowboys are two teams on different paths late in the season. Arizona has lost three consecutive games, conceding their lead in the NFC West to the Los Angeles Rams. Dallas is on a four-game win streak, and they boast a three-game lead over the Philadelphia Eagles for the NFC East. Below, you’ll find the NFL odds along with our pick and prediction for the Cardinals vs. Cowboys matchup in Week 17.
Arizona Cardinals vs. Dallas Cowboys pick, prediction | Week 17
- Spread: Cowboys -5.5 (Odds provided by DraftKings Sportsbook)
- Moneyline:Â Cardinals +185, Cowboys -225
- Over/Under:Â 49.5
Arizona’s recent struggles
The Cardinals are on one of the longest losing streaks in the NFL right now. They’ve been defeated in each of their last three games, including to less than stellar competition. Arizona lost to the Los Angeles Rams and Indianapolis Colts in potential playoff previews over that span. The bigger concern was a 30-12 loss to the Detroit Lions between those games.
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Arizona’s offense has sputtered, as they rank in the bottom-five of the NFL in points per play during their losing streak. They also rank in the bottom-10 of the league in points per play allowed over that span. Arizona was undefeated on the road prior to their embarrassing loss to the Lions. They boasted a 7-0 road record with wins over stout teams. Ultimately, the Cardinals have taken a massive step back from their early-season form.
Cardinals vs. Cowboys betting trends
Both of these teams have found success against the spread (ATS) this season. Dallas boasts a league-best 12-3 ATS record, while Arizona sits at 9-6.
The Cardinals have been elite on the road, where they’ve covered the spread in a league-high 87.5% of their games. They’re covering by an average of 10.6 points per game on the road.
The Cowboys have found plenty of success at home, covering in 71.4% of games in Dallas. They’re covering by an average of 9.6 points per game in those contests.
Each of these teams leans slightly toward the under in their games. They both own a 7-8 over/under record, hitting the under in 53.3% of their contests in 2021.
Cardinals vs. Cowboys prediction
If the Cardinals were going to right the ship before the playoffs, this would be the perfect week for that to happen. They look all out of sorts, though, and their coaching has played a major part in that.
The Cowboys, on the other hand, continue to produce. Dak Prescott looks healthier and healthier each week, as he’s coming off of an elite performance against the Washington Football Team.
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I don’t anticipate Arizona turning their season around this week. Dallas is one of the hottest teams in the NFL, and they have too many weapons for this matchup. Nevertheless, I believe this game will stay relatively close with a playoff environment.
Cardinals vs. Cowboys Prediction: Cowboys 27, Cardinals 24

