Fantasy football managers are always looking for the perfect time to strike a deal that could make or break their season. The trade market in Week 5 presents some compelling opportunities, with certain players positioned as prime buy-low candidates after slow starts.
On the flip side, some receivers are riding hot streaks that make them ideal sell-high targets before potential regression hits. Smart managers who act quickly on these trade opportunities could gain a significant edge over their competition.
Top Trade Targets To Buy: Jameson Williams, Detroit Lions
Jameson Williams was tipped by many for a big year in 2025, but has started the season with three fantasy finishes outside the top 50 wide receivers in the opening four weeks. Against Cleveland in Week 4, Williams caught two passes for 40 yards, but he was targeted eight times.
Many of those targets were deep balls and potential walk-in touchdowns, but Jared Goff could not connect. Williams remains a big-play threat, and the Detroit Lions will look to get him going in the coming weeks.
Having started slowly, the Lions have scored 116 points in their last three games, and Williams’s eight targets clearly indicate that Detroit wants him involved. The electric deep threat was the WR22 overall last season and should be available at a huge discount this week.
Jauan Jennings, San Francisco 49ers
Jauan Jennings remains Brock Purdy’s favorite target, but the wide receiver struggled to make an impact in Week 4. The San Francisco 49ers lost 26-21 to the Jacksonville Jaguars, whose defense continues to be underrated.
Brock Purdy (toe), Jauan Jennings (ankle, rib), and Ricky Pearsall (knee) wouldn’t have been able to practice today…
Mac Jones would have been full-go pic.twitter.com/RdqyOM7V28
— Coach Yac 🗣 (@Coach_Yac) September 29, 2025
Jennings was targeted just four times, catching two, having missed Week 3 through injury. Jennings also missed some time in Week 4, having taken a heavy shot to his midsection, but should be good to go for Week 5.
Jennings has posted only one fantasy-relevant week through four weeks, finishing as the WR11 overall in Week 2. The 49ers travel to the Los Angeles Rams in Week 5, where Jennings tallied 175 yards and three touchdowns last season.
Top Trade Targets To Sell: Marvin Harrison Jr., Arizona Cardinals
Marvin Harrison Jr. continues to be a boom/bust fantasy receiver, making this week an excellent opportunity to cash in for a more consistent asset. At the time of writing, there are still two games to play in Week 4, but Harrison is currently ranked inside the top 12 receivers in fantasy for the second time this season.
However, Harrison finished as the WR51 and the WR83 overall in the other two weeks of the year. That volatility is nothing new, having plagued him throughout his rookie year.
Harrison scored a touchdown against Seattle, papering over the cracks of another concerning performance, riddled with mistakes between him and his quarterback. Harrison and Kyler Murray were again on different wavelengths throughout the contest, suggesting more disappointing weeks are to come.
Luke McCaffrey, Washington Commanders
For those who added Luke McCaffrey after his impressive performance in Week 3, he produced another flex-worthy display in Week 4. The receiver has turned six targets into five catches for 77 yards and two touchdowns over the past two weeks.
Second-year breakouts aren’t uncommon; some will be willing to take a shot on a young receiver with elite bloodlines. However, unlike Ertz, McCaffrey’s breakout has coincided with his quarterback’s absence.
It’s also no coincidence that McCaffrey’s numbers have risen with Terry McLaurin sidelined, though McLaurin’s injury timeline is unclear. What is clear, though, is that Daniels loves to throw to his trusted tight end.
While McCaffrey should continue to see more work with McLaurin out, it’s likely to be Ertz who takes on a far larger role with Daniels back on the field.
