49ers vs. Vikings Player Prop Bets for Monday Night Football: Brandon Aiyuk, George Kittle, T.J. Hockenson, and Others

Although both Justin Jefferson and Deebo Samuel are  out for this game, there is still enough firepower at the skill positions for both offenses in this week’s Monday Night Football game between the San Francisco 49ers and Minnesota Vikings.

But as Jefferson continues to be sidelined, there remain plenty of targets up for grabs for the Vikings’ pass catchers. Which player prop bets should you be targeting on the Vikings? Can Brock Purdy bounce back after having the worst start of his short career last week in Cleveland? Let’s get into the favorite 49ers vs. Vikings player prop bets from the PFN betting team.

Our Betting Lines page has the freshest lines and promos to get BANG for your buck. PFN’s FREE Parlay Calculator and Betting Odds Calculator are also available for your betting process! New to sports betting? Check out our guide on How to Bet on the NFL. Visit our Sports Betting Legal Tracker on how to bet legally in the U.S.

Top San Francisco 49ers vs. Minnesota Vikings Player Prop Bets To Target

Our team of betting experts gives out their favorite player prop bets for the 49ers vs. Vikings on Monday Night Football.

All odds are from DraftKings Sportsbook unless noted otherwise.

Brock Purdy Player Props

• Passing Yards: 237.5 (Over -115/Under -115)
• Pass Touchdowns: 1.5 (Over -115/Under -115)
• Interceptions: 0.5 (Over +160/Under -210)

Soppe: We can all agree that Purdy isn’t fleet of foot, right? Well, before the Week 6 dud in Cleveland, he had a rushing score or multiple passing touchdowns in every one of his regular season starts. If we are to believe that the rushing scores are random, I’m happy to bet against them, and that means multiple passing touchdowns.

MORE: NFL Survivor Picks Week 7

The final thing to consider — and this could be slightly impacted by the health of the 49er skill guys, but it is still worth noting — through six weeks, the Vikings drop passes at a top-10 rate (highest drop rate, bad) while the 49ers are bottom-10 in drop rate. If one of these QBs is going to get help from his friends, it’s Purdy.

Pick: Brock Purdy over 1.5 touchdown passes (-110 at DraftKings)

Brandon Aiyuk Player Props

• Receiving Yards: 67.5 (Over -115/Under -115)
• Anytime Touchdown Scorer: +140
• First Touchdown Scorer: +800

Katz: Brandon Aiyuk has played five games this season. He’s recorded at least 76 receiving yards in three of them.

Tonight, we have a great spot against a Vikings defense that struggles to defend wide receivers. They’ve allowed the second most fantasy points to outside receivers. While this isn’t a fantasy pick, that is indicative of their struggles.

Aiyuk primarily plays the outside. A whopping 80% of the Vikings receiving yards allowed has gone to the WR position, by far the most in the league.

With McCaffrey and Samuel banged up, this should be a heavy Aiyuk game.

Pick: Brandon Aiyuk over 65.5 receiving yards (-115 at DraftKings)

George Kittle Player Props

• Receiving Yards: 47.5 (Over -115/Under -115)
• Anytime Touchdown Scorer: +155
• First Touchdown Scorer: +900

Blewis: The only five teams that have allowed fewer receiving yards to tight ends this season than the Vikings, and three of them have played one less game. This is despite matchups against premier tight ends such as Travis Kelce and Dallas Goedert.

On the surface, you would think that George Kittle would be poised for a bigger role in this game if the 49ers were without two of their best weapons. But with how the Vikings have defended tight ends this season, combined with Kittle’s volatile usage, I’m most inclined to take him under, but I would maybe wait to see if the line goes up.

Pick: George Kittle under 47.5 receiving yards (-115 at DraftKings)

Kirk Cousins Player Props

• Passing Yards: 237.5 (Over -115/Under -115)
• Pass Touchdowns: 1.5 (Over +160/Under -210)
• Pass Completions: 24.5 (Over -110/Under -120)
• Pass Attempts: 36.5 (Over -105/Under -125)
• Rushing Yards: 2.5 (Over -125/Under -105)
• Interceptions: 0.5 (Over -125/Under -105)

Let’s first deal with an injury we know — Justin Jefferson. The All-Pro receiver is on injured reserve, and the Vikings will not have his services until November at the earliest. That has a massive impact on how the Vikings’ offense functions, and while we are dealing with small sample sizes, here are Kirk Cousins’ splits in games this season that Jefferson starts and finishes vs. games he does not.

aDOT:

• With full Jefferson: 8.06 yards
• Without full Jefferson: 6.97

Yards per pass:

• With full Jefferson: 7.73 yards
• Without full Jefferson: 5.96

Soppe: For those who struggle with math, that’s a 13.5% decline in average depth of target and 22.9% in yards per attempt. As I said, it’s a small sample, but those numbers track with what you’d assume would happen — Jefferson thrusts receivers into an uncomfortable role and puts more looks on the plate of RB/TEs.

Those are low-risk, low-reward throws, and I’m banking on that continuing against a 49ers team that is top 10 in pressure rate despite a bottom-5 blitz rate. How many passes will Cousins throw?

You might be inclined to jack up the attempt count to game script, but be careful. The Vikings, even with Jefferson for over two-thirds of their games, rank dead last in time of possession, while the 49ers rank fourth for a second consecutive season.

The limited number of possessions and low-risk throws have me trending toward prime-time Cousins playing a clean, albeit uninspiring, game.

Picks: Kirk Cousins under 237.5 passing yards (-115 at DraftKings), Kirk Cousins under 0.5 interceptions (-105 at DraftKings)

Alexander Mattison Player Props

• Rushing Yards: 44.5 (Over -115/Under -115)
• Receiving Yards: 19.5 (Over -115/Under -115)
• Receptions: 3.5 (Over +105/Under -135)
• Anytime Touchdown Scorer: +155
• First Touchdown Scorer: +1000

Blewis: In the four Vikings losses this season, Alexander Mattison has averaged 11.8 carries per game, and this number is inflated by the Chargers loss in which he had 20 rushing attempts.

MORE: NFL Bets and Expert Picks Week 7

The point spread for that game was a pick, while this week, they’re getting a touchdown at home. Regardless of their injuries, I don’t think the 49ers should have issues winning this one, which leads me to believe a negative game script is in play for Mattison.

Pick: Alexander Mattison under 12.5 rush attempts (-114 at FanDuel)

T.J. Hockenson Player Props

• Receiving Yards: 49.5 (Over -115/Under -115)
• Receptions: 5.5 (Over -110/Under -120)
• Longest Reception: 17.5 (Over -115/Under -115)
• Anytime Touchdown Scorer: +220
• First Touchdown Scorer: +1300

Blewis: In their first game without Jefferson last week, T.J. Hockenson led the way with eight targets, with Kirk Cousins throwing over 25% of his passes his way. But that was in a game in which the Vikings never trailed, and the winds impacted both teams’ ability to throw.

The 49ers have been good at defending tight ends this season, allowing less than four receptions per game, but it’s hard for me to fade Hockenson here. After Jefferson’ he is easily Cousins’ most trusted pass catcher, and he should be his primary weapon in a matchup where they’re more likely to be playing from behind than last week.

In the first five games with Jefferson in the lineup, Hockenson went over 5.5 receptions in three of five games.

Pick: T.J. Hockenson over 5.5 receptions (-110 at DraftKings)