How do our Week 16 fantasy football flex rankings shape up with injuries and positive COVID tests hurting the fantasy landscape? Do you have the depth on your roster to cover any holes, or is a trip to the waiver wire required for Week 16 before Thursday Night Football begins?
Week 16 Fantasy Football Flex Rankings | 1-10
1. Jonathan Taylor | RB | Indianapolis Colts @ ARI
2. Cooper Kupp | WR | Los Angeles Rams @ MIN
3. Dalvin Cook | RB | Minnesota Vikings vs. LAR
4. Justin Jefferson | WR | Minnesota Vikings vs. LAR
5. Austin Ekeler | RB | Los Angeles Chargers @ HOU
6. Davante Adams | WR | Green Bay Packers vs. CLE
7. Alvin Kamara | RB | New Orleans Saints vs. MIA
8. Deebo Samuel | WR | San Francisco 49ers @ TEN
9. James Robinson | RB | Jacksonville Jaguars @ NYJ
10. Keenan Allen | WR | Los Angeles Chargers @ HOU
11-20
11. Diontae Johnson | WR | Pittsburgh Steelers @ KC
12. Stefon Diggs | WR | Buffalo Bills @ NE
13. Nick Chubb | RB | Cleveland Browns @ GB
14. CeeDee Lamb | WR | Dallas Cowboys vs. WAS
15. Cordarrelle Patterson | RB | Atlanta Falcons vs. DET
16. Ja’Marr Chase | WR | Cincinnati Bengals vs. BAL
17. Aaron Jones | RB | Green Bay Packers vs. CLE
18. Antonio Brown | WR | Tampa Bay Buccaneers @ CAR
19. Josh Jacobs | RB | Las Vegas Raiders vs. DEN
20. Najee Harris | RB | Pittsburgh Steelers @ KC
21-30
21. Joe Mixon | RB | Cincinnati Bengals vs. BAL
22. Tee Higgins | WR | Cincinnati Bengals vs. BAL
23. George Kittle | TE | San Francisco 49ers @ TEN
24. David Montgomery | RB | Chicago Bears @ SEA
25. Ronald Jones II | RB | Tampa Bay Buccaneers @ CAR
26. Antonio Gibson | RB | Washington Football Team @ DAL
27. Jaylen Waddle | WR | Miami Dolphins @ NO
28. DK Metcalf | WR | Seattle Seahawks vs. CHI
29. Brandin Cooks | WR | Houston Texans vs. LAC
30. Marquise Brown | WR | Baltimore Ravens @ CIN
RB/WR/TE Options for Week 16 | 31-40
31. Mark Andrews | TE | Baltimore Ravens @ CIN
32. Clyde Edwards-Helaire | RB | Kansas City Chiefs vs. PIT
33. Ezekiel Elliott | RB | Dallas Cowboys vs. WAS
34. James Conner | RB | Arizona Cardinals vs. IND
35. Hunter Renfrow | WR | Las Vegas Raiders vs. DEN
36. Adam Thielen | WR | Minnesota Vikings vs. LAR
37. Terry McLaurin | WR | Washington Football Team @ DAL
38. Amari Cooper | WR | Dallas Cowboys vs. WAS
39. Gabriel Davis | WR | Buffalo Bills @ NE
40. Mike Williams | WR | Los Angeles Chargers @ HOU
41-50
41. Van Jefferson | WR | Los Angeles Rams @ MIN
42. Amon-Ra St. Brown | WR | Detroit Lions @ ATL
43. Jeff Wilson Jr. | RB | San Francisco 49ers @ TEN
44. Brandon Aiyuk | WR | San Francisco 49ers @ TEN
45. Javonte Williams | RB | Denver Broncos @ LV
46. Odell Beckham Jr. | WR | Los Angeles Rams @ MIN
47. D’Onta Foreman | RB | Tennessee Titans vs. SF
48. Saquon Barkley | RB | New York Giants @ PHI
49. Rhamondre Stevenson | RB | New England Patriots vs. BUF
50. DJ Moore | WR | Carolina Panthers vs. TB
51-60
51. Sony Michel | RB | Los Angeles Rams @ MIN
52. Rob Gronkowski | TE | Tampa Bay Buccaneers @ CAR
53. Darnell Mooney | WR | Chicago Bears @ SEA
54. A.J. Brown | WR | Tennessee Titans vs. SF
55. Michael Pittman Jr. | WR | Indianapolis Colts @ ARI
56. Christian Kirk | WR | Arizona Cardinals vs. IND
57. Russell Gage | WR | Atlanta Falcons vs. DET
58. Chase Claypool | WR | Pittsburgh Steelers @ KC
59. DeVonta Smith | WR | Philadelphia Eagles vs. NYG
60. A.J. Green | WR | Arizona Cardinals vs. IND
Week 16 Flex Rankings | 61-70
61. Miles Sanders | RB | Philadelphia Eagles vs. NYG
62. Michael Gallup | WR | Dallas Cowboys vs. WAS
63. DeVante Parker | WR | Miami Dolphins @ NO
64. Jakobi Meyers | WR | New England Patriots vs. BUF
65. Melvin Gordon III | RB | Denver Broncos @ LV
66. AJ Dillon | RB | Green Bay Packers vs. CLE
67. Dallas Goedert | TE | Philadelphia Eagles vs. NYG
68. Tyler Boyd | WR | Cincinnati Bengals vs. BAL
69. Josh Reynolds | WR | Detroit Lions @ ATL
70. Jamison Crowder | WR | New York Jets vs. JAX
71-80
71. Rashaad Penny | RB | Seattle Seahawks vs. CHI
72. Zach Ertz | TE | Arizona Cardinals vs. IND
73. Michael Carter | RB | New York Jets vs. JAX
74. Tyler Johnson | WR | Tampa Bay Buccaneers @ CAR
75. Devin Singletary | RB | Buffalo Bills @ NE
76. Kyle Pitts | TE | Atlanta Falcons vs. DET
77. Devonta Freeman | RB | Baltimore Ravens @ CIN
78. Mike Gesicki | TE | Miami Dolphins @ NO
79. Dawson Knox | TE | Buffalo Bills @ NE
80. Mecole Hardman | WR | Kansas City Chiefs vs. PIT
81-90
81. Dalton Schultz | TE | Dallas Cowboys vs. WAS
82. Hunter Henry | TE | New England Patriots vs. BUF
83. K.J. Osborn | WR | Minnesota Vikings vs. LAR
84. Noah Fant | TE | Denver Broncos @ LV
85. Laquon Treadwell | WR | Jacksonville Jaguars @ NYJ
86. Jerry Jeudy | WR | Denver Broncos @ LV
87. Byron Pringle | WR | Kansas City Chiefs vs. PIT
88. Emmanuel Sanders | WR | Buffalo Bills @ NE
89. Darrell Henderson Jr. | RB | Los Angeles Rams @ MIN
90. Jared Cook | TE | Los Angeles Chargers @ HOU
RB/WR/TE Options for Week 16 | 91-100
91. Tony Pollard | RB | Dallas Cowboys vs. WAS
92. Darrel Williams | RB | Kansas City Chiefs vs. PIT
93. Tyler Conklin | TE | Minnesota Vikings vs. LAR
94. Mike Davis | RB | Atlanta Falcons vs. DET
95. Rashod Bateman | WR | Baltimore Ravens @ CIN
96. Kenny Golladay | WR | New York Giants @ PHI
97. Myles Gaskin | RB | Miami Dolphins @ NO
98. Marvin Jones Jr. | WR | Jacksonville Jaguars @ NYJ
99. Craig Reynolds | RB | Detroit Lions @ ATL
100. Braxton Berrios | WR | New York Jets vs. JAX
101-110
101. Chase Edmonds | RB | Arizona Cardinals vs. IND
102. Chuba Hubbard | RB | Carolina Panthers vs. TB
103. Allen Lazard | WR | Green Bay Packers vs. CLE
104. Laviska Shenault Jr. | WR | Jacksonville Jaguars @ NYJ
105. Cole Kmet | TE | Chicago Bears @ SEA
106. Duke Johnson Jr. | RB | Miami Dolphins @ NO
107. Donovan Peoples-Jones | WR | Cleveland Browns @ GB
108. Robby Anderson | WR | Carolina Panthers vs. TB
109. Julio Jones | WR | Tennessee Titans vs. SF
110. C.J. Uzomah | TE | Cincinnati Bengals vs. BAL
111-120
111. Evan Engram | TE | New York Giants @ PHI
112. Tim Patrick | WR | Denver Broncos @ LV
113. Jamaal Williams | RB | Detroit Lions @ ATL
114. Brandon Bolden | RB | New England Patriots vs. BUF
115. Rex Burkhead | RB | Houston Texans vs. LAC
116. Zay Jones | WR | Las Vegas Raiders vs. DEN
117. Devontae Booker | RB | New York Giants @ PHI
118. Courtland Sutton | WR | Denver Broncos @ LV
119. Tevin Coleman | RB | New York Jets vs. JAX
120. Jordan Howard | RB | Philadelphia Eagles vs. NYG
Week 16 Flex Rankings | 121-130
121. Adam Humphries | WR | Washington Football Team @ DAL
122. Scotty Miller | WR | Tampa Bay Buccaneers @ CAR
123. Marquez Callaway | WR | New Orleans Saints vs. MIA
124. James O’Shaughnessy | TE | Jacksonville Jaguars @ NYJ
125. Dontrell Hilliard | RB | Tennessee Titans vs. SF
126. T.Y. Hilton | WR | Indianapolis Colts @ ARI
127. Darius Slayton | WR | New York Giants @ PHI
128. Keelan Cole Sr. | WR | New York Jets vs. JAX
129. Nico Collins | WR | Houston Texans vs. LAC
130. Nyheim Hines | RB | Indianapolis Colts @ ARI
131-140
131. Damiere Byrd | WR | Chicago Bears @ SEA
132. Zach Pascal | WR | Indianapolis Colts @ ARI
133. Bryan Edwards | WR | Las Vegas Raiders vs. DEN
134. Ameer Abdullah | RB | Carolina Panthers vs. TB
135. Latavius Murray | RB | Baltimore Ravens @ CIN
136. Mike Evans | WR | Tampa Bay Buccaneers @ CAR
137. Antoine Wesley | WR | Arizona Cardinals vs. IND
138. Foster Moreau | TE | Las Vegas Raiders vs. DEN
139. Gerald Everett | TE | Seattle Seahawks vs. CHI
140. Demarcus Robinson | WR | Kansas City Chiefs vs. PIT
141-150
141. Isaiah McKenzie | WR | Buffalo Bills @ NE
142. Ricky Seals-Jones | TE | Washington Football Team @ DAL
143. Olamide Zaccheaus | WR | Atlanta Falcons vs. DET
144. Kalif Raymond | WR | Detroit Lions @ ATL
145. James Washington | WR | Pittsburgh Steelers @ KC
146. David Njoku | TE | Cleveland Browns @ GB
147. Ke’Shawn Vaughn | RB | Tampa Bay Buccaneers @ CAR
148. Samaje Perine | RB | Cincinnati Bengals vs. BAL
149. Tre’Quan Smith | WR | New Orleans Saints vs. MIA
150. Brandon Zylstra | WR | Carolina Panthers vs. TB
