Facebook Pixel

    Christian McCaffrey Injury Update: 49ers RB Poised To Make His Season Debut

    In one of the strangest injury timelines you will ever see, Christian McCaffrey went from being expected to play in Week 1 to the team holding him out a week to missing the entire first half of the season. Now finally set to take the field, is the San Francisco 49ers RB playing in Week 10?

    PFSN NFL Playoff Predictor
    Try out PFSN’s FREE playoff predictor, where you can simulate every 2025-26 NFL season game and see how it all shakes out!

    What Is Christian McCaffrey’s Injury?

    The best running back in football has not played at all this year due to the combination of a calf strain and Achilles tendinitis. However, it is the latter that has lingered for the past two months, keeping him out of NFL action.

    In a saga that had many twists and turns, the 49ers went from playing it safe with McCaffrey to putting him on IR indefinitely. Early in the season, it was genuinely uncertain whether McCaffrey would play at all this season.

    Not only did McCaffrey undergo extensive treatment from team doctors, but he flew to Germany for special treatment not available here. Whether McCaffrey is truly back to 100% remains to be seen. Fortunately, he’s looked good at practice.

    Reportedly, the Achilles tendinitis will never go away 100%. However, it has recovered enough to the point where the team feels comfortable putting McCaffrey on the field. While his odds of tearing his Achilles may be slightly higher than the average player without tendinitis, it’s still not a probable occurrence. In all likelihood, McCaffrey will be fine.

    Is McCaffrey Playing This Week?

    We shouldn’t assume anything is 100% until it happens. As a reminder, McCaffrey was also playing in Week 1 until he wasn’t. However, given the way things have played out over the past two months, we should have every bit of confidence in the world that we will see McCaffrey this week.

    On Saturday, the team officially activated the running back from IR. Again, we should believe McCaffrey is back when we see him on the field. However, his activation from IR sets the stage for him to play for the first time all season, this week against the Tampa Bay Buccaneers.

    How Might McCaffrey’s Absence Impact the Texans if Ruled Out?

    In the event McCaffrey does miss time again in the future, I’m not sure the backfield hierarchy is as clear-cut. It was very clearly Jordan Mason as the feature back to open the season. He operated in that role for the entire nine weeks … at least when he was healthy.

    Over the past couple of weeks, Mason has been dealing with a shoulder injury. That opened the door for rookie Isaac Guerendo to really step up. He’s been impressive, averaging 6.1 yards per carry.

    If McCaffrey were to go down again, there’s a nonzero chance it would be Guerendo as the next man up rather than Mason.

    The 49ers are also set to get Deebo Samuel Sr. and Jauan Jennings back. Samuel left the team’s Week 8 game with a rib issue and has been limited at practice. Jennings has been out multiple weeks with a hip injury. While Brandon Aiyuk is sadly done for the year with a torn ACL, this projects to be the healthiest the 49ers have been all season.

    2026 NFL Mock Draft Simulator

    The PFSN Mock Draft Simulator features hundreds of prospects, scouting reports, and free trades -- jump into the mock draft machine and get ready for the 2026 NFL Draft.

    2026 NFL Draft Big Board Builder

    PFSN’s free NFL Draft Big Board Builder allows you to rank every prospect in the NFL Draft and share it with the world.

    2025 NFL Playoff Predictor

    PFSN's 2025 NFL Season and Playoff Predictor is a tool that allows you to play out various weekly scenarios to see how the NFL playoff picture changes with each scenario.

    NFL Offseason Manager

    Do you think you can manage your favorite team’s roster better than the real-life general managers? PFN's Offseason Manager is here to help you prove it.

    NFL Injury Update Week 12: Latest on Bucky Irving, Trey Benson, Joe Mixon, Brian Thomas Jr., Others

    The Week 12 NFL Injury Update offers the latest on players like Bucky Irving, Trey Benson, C.J. Stroud, Aaron Rodgers, Lane Johnson, and others.

    How Long Will Mike Evans Be Out? Latest on Buccaneers Star’s Injury and Return Timeline Ahead of Week 12

    Mike Evans’ status remains in flux as the Tampa Bay Buccaneers navigate a vital stretch in the NFC South race with the Los Angeles Rams up next.

    Jaxson Dart Injury Update: What’s the Latest on the Giants QB, and Will He Play in Week 12?

    New York Giants quarterback Jaxson Dart is working his way back from concussion protocol, making him a player to watch in Week 12.

    NFL MVP Offers Advice to Jayden Daniels After Gruesome Injury, Weighs In on Robert Griffin III Comparisons

    A former Washington quarterback and NFL MVP discussed Jayden Daniels' elbow injury and the eerie comparisons to Robert Griffin III.
    Join the Conversation!

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    Free NFL Tools

    NFL Offense Impact

    NFL Defense Impact