As the NFL heads into Week 4 of the 2025 season, the matchup between the Arizona Cardinals and the Seattle Seahawks promises to be a critical divisional showdown. Both teams are 2-1 in the NFC West.
Where Do the Two Teams Stand Entering Week 4?
The Arizona Cardinals have started the season 2-1, following a narrow loss to the San Francisco 49ers in Week 3 after winning their first two games. The Cardinals’ defense has been a consistent strength, allowing just 17 points per game, which ranks tied for fifth-best in the NFL.
However, the offense faces significant challenges, especially with star running back James Conner out for the season due to a foot injury.
Conversely, the Seattle Seahawks are in a strong position going into Week 4 after winning two straight games after suffering a defeat to the San Francisco 49ers in the first week. Under head coach Mike Macdonald, the Seahawks have shown themselves to be a balanced and opportunistic squad by defeating the Pittsburgh Steelers and New Orleans Saints in Weeks 2 and 3.
The Seahawks’ historically strong run defense could challenge the Cardinals’ limited rushing attack, making the game a test of patience and execution for Arizona’s offense.
These trends, combined with Seattle’s strong defense and efficient offense, make them slight favorites on the road. Nonetheless, Arizona’s defense and home-field advantage could keep the game close, setting the stage for a low-scoring, high-stakes matchup.
Seattle Seahawks at Arizona Cardinals
Game Details
Date: Thursday, September 25, 2025
Time: 8:15 p.m. EST
Location: State Farm Stadium, Glendale, Ariz.
How to Watch
TV: Amazon Prime Video
Live Stream: NFL+ and NFL Network
Radio: Arizona Sports 98.7 FM, Seattle Sports 710AM, KIRO Newsradio 97.3 FM (Seattle)
Arizona Will Look to Change Its Difficult History Against Seattle
The Cardinals will have to find ways to get better offensively without Conner while relying on their defensive identity. The key to Arizona’s success will probably be Murray’s ability to connect with his top targets and Trey Benson’s steady run game output. Another important factor may be the health of the offensive line, namely the condition of Paris Johnson Jr. and Kelvin Beachum.
Meanwhile, the Seahawks aim to continue their winning streak over Arizona, relying on Sam Darnold’s chemistry with his receivers and a stingy defensive front to contain the Cardinals’ attack. Seattle’s balanced approach on both sides of the ball makes them a formidable opponent, but a resilient Arizona defense could keep the game within reach, potentially creating opportunities for turnovers and momentum-shifting plays.
Arizona faces a tough history against Seattle, having lost the last seven meetings overall and four straight in Glendale. Seattle has also enjoyed a remarkable run under Macdonald, winning eight of their last nine road games and seven consecutive away contests against the Cardinals.
This Thursday night matchup is more than just a regular-season game. It’s a pivotal NFC West contest where both teams are vying to avoid falling behind in the division.
