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Week 16 NFL Picks: Los Angeles Rams vs San Francisco 49ers
Image credit: Mark J. Rebilas-USA TODAY Sports

NFL Betting

Week 16 NFL Picks: Los Angeles Rams vs San Francisco 49ers

This is a game many would have expected to be a chance for the San Francisco 49ers to put a dagger in the Los Angeles Rams playoff hopes. As it turns out, it is, but not in the way we might have thought. Instead of the Rams fighting for the top seed in the conference, they are struggling to stay alive in the race for the final wildcard spot. Meanwhile, it is the 49ers who need to win on Saturday if they are to have a real chance of locking up both a first-round bye and a home-field advantage in Seattle in Week 17.

Location: Levi’s Stadium
Time: 8:15 pm EST
Spread: 49ers -6.5
O/U: 45

The money has been pilling in on the 49ers, with over 80% of the money so far coming in on the team from the Bay. It is surprising that this line has not already jumped to 7 in more places. The money on the total has been almost 50/50 and that has caused a slight shift down from 45.5 to 45. That is because despite the split being even in the money, the number of bets has been leaning towards the under, suggesting the big bettors are taking the under in this one.

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Bet predictions from Ben Rolfe

This game is a really tough one to call and while I think the 49ers and their defense will dominate, I am going to stay clear. Instead, I am going to look at Robert Woods’ total receptions. In his past four games, Woods has been targeted 45 times, pulling in 30 receptions in that span. With the line set at 4.5 receptions, I expect him to beat this with ease. However, with the odds at -148, I would not be surprised to see this flick to 5.5 before kick-off. I would still take a chance at a line of 5.5, but it would just be a single unit play.”

2u – Robert Woods Over 4.5 receptions | -148 

Bet predictions from Chris Smith

From Twitter for his Week 16 49ers/Rams NFL picks: “December divisional unders are 11-6 so far this month. Keep in mind the two later Saturday games are divisional matchups. I’m leaning towards under 45 in the 49ers Saturday night game. In fact, make that an official one unit play.

1u – Under 45 Total Points | -125

Bet predictions from Aaron Sutton

I’d lean SF -6.5. The Rams gave up almost 300 yards of rushing last week on the road in a game where they should’ve been desperate — and now they’re going on the road to take on the #2 rushing attack. Rams still technically have a Playoff chance, but motivationally, I think this favors SF as well — there’s more of a chance SF gets home-field advantage than Rams making the Playoffs.

The last loss the 49ers had before the Atlanta loss was in Baltimore, losing 20-17. They responded to that by going on the road to New Orleans and winning one of the best games of the year so far 48-46. I like their chances of bouncing back this week.”

Want more betting analysis? Click for the latest from the PFN Betting Crew. Be sure to also follow us on Twitter: @PFN365.

Running List of PFN Bets for This Week 

Click to view the running list of our bets for this week and the 2020 NFL Season. Be sure to bookmark that page and visit it often throughout the week to stay updated on our latest moves.

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