49ers vs. Chargers: How to watch, start time, odds, live streams, TV channel

What time does the 49ers vs. Chargers game start, what TV channel is it on, where can you live stream it, and what are the latest odds?

Could the San Francisco 49ers vs. Los Angeles Chargers be the beginning of a Trey Lance and Justin Herbert rivalry? This week, we will get our first look at what could be a display of two of the more dynamic offenses in the NFL. Let’s take a look at the start time, TV channel, how you can live stream the game, and the current NFL odds for 49ers vs. Chargers.

San Francisco 49ers vs. Los Angeles Chargers | Preseason Week 2

Last week, we saw Lance in his first NFL action for the 49ers. While it was an up-and-down performance, the most memorable moment was a beautiful 80-yard touchdown pass on his second throw of the game.

Last week, we did not see Chargers sophomore QB Justin Herbert, as Chase Daniel and Easton Stick shared QB duties against the Rams. Will Herbert play this week against San Francisco?

How to watch, live streams, TV channel, & more

  • Time: 7:30 PM, August 22
  • TV channel: NFL Network
  • Live streams:

Check with your streaming service to confirm the availability of specific channels.

49ers vs. Chargers | Current NFL odds, spreads, betting lines, and predictions

  • Spread: 49ers -5 (-115)
  • Moneyline: 49ers -235, Chargers +190
  • Total: 34 (Over -115, Under -105)

The 49ers open as big favorites with the tandem of Lance and Jimmy Garoppolo under center. This number would likely change if it was announced that Herbert would get some playing time this week.

There are two reasons that I like the Chargers with the points in this one. Last week, Lance was sacked a whopping 4 times. The 49ers’ offensive line has struggled and the Chargers’ defensive line is not the unit you want to be lined up against when you are trying to figure things out.

Secondly, the 49ers have an incredibly young secondary. Even if Herbert doesn’t play, Stick went 7/7 and looked confident in the pocket. Similarly, Daniel, who has been one of the more reliable backup QBs in the NFL, also looked solid going 15/24 for over 100 yards. The combination of the two — with the possibility of Herbert — is enough for me to take the points at more than a field goal. I also think there is value on the moneyline (+190).

49ers vs. Chargers series history

The 49ers vs. Chargers series has not been around for very long. The two teams have met each other 15 times (including Super Bowl XXIX), with the Chargers winning eight games and the 49ers winning seven. The 49ers had won six straight meetings between the two, but the Chargers have responded with five consecutive wins.

  • Chargers 20-17 49ers | 2002
  • Chargers 48-19 49ers | 2006
  • Chargers 34-7 49ers | 2010
  • Chargers 38-35 49ers | 2014
  • Chargers 29-27 49ers | 2018

49ers 2021 preseason schedule

  • Week 1 | vs. Kansas City Chiefs (L 16-19) | August 14
  • Week 2 | @ Los Angeles Chargers | August 22
  • Week 3 | vs. Las Vegas Raiders | August 29

Chargers 2021 preseason schedule

  • Week 1 | @ Los Angeles Rams (W 13-6) | August 14
  • Week 2 | vs. San Francisco 49ers | August 22
  • Week 3 | @ Seattle Seahawks | August 28

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