NFL Week 12 Odds and Betting Trends Against the Spread: Christian McCaffrey On Thanksgiving, Lamar Jackson vs. Justin Herbert in Primetime, and More

Four days of football and plenty on intrigue. The Week 12 NFL odds offer some interesting numbers -- who do the trends favor?

The NFL Week 12 odds are all over the place and require some serious thought. The week starts with a Thanksgiving triple-header and has a handful of games that could drastically impact the playoff picture when all is said and done.

How are we using these trends? The PFN Betting Podcast runs through every single game as we head into the weekend.

NFL Week 12 Odds and Betting Trends

All odds are from ESPN BET, and betting trends are from Inside Edge.

Green Bay Packers vs. Detroit Lions Odds

    • Spread
      Lions -7.5
    • Moneyline
      Packers +290, Lions -360
    • Total
      47.5

Unders are 8-3 in Green Bay’s past 11 games against top 10 pass offenses.

The Lions have won four straight against the Packers and have held Green Bay to a total of 45 points over their past three meetings.

Washington Commanders vs. Dallas Cowboys Odds

    • Spread
      Cowboys -10.5
    • Moneyline
      Commanders +425, Cowboys -550
    • Total
      48.5

The Commanders are the third-best road ATS team since the beginning of last season (8-5).

The Cowboys have covered 16 of their past 20 games when favored.

San Francisco 49ers vs. Seattle Seahawks Odds

    • Spread
      49ers -6.5
    • Moneyline
      49ers -290, Seahawks +240
    • Total
      43.5

The 49ers had lost 15 of 17 to the Seahawks but have won three straight in this series (average point differential: 15.3 points).

The Seahawks are 5-2 ATS in their past seven games as a home underdog.

Miami Dolphins vs. New York Jets Odds

    • Spread
      Dolphins -9.5
    • Moneyline
      Dolphins -500, Jets +385
    • Total
      40.5

The Dolphins have covered eight of their past 10 games against bottom 10 pass offenses.

The home team has won seven of the past nine meetings in this series (eight of the past 11 in this series have been decided by a single possession).

New Orleans Saints vs. Atlanta Falcons Odds

    • Spread
      Falcons -1
    • Moneyline
      Saints -110, Falcons -110
    • Total
      42.5

With the Saints winning six of the past seven (and nine of the past 11) against the Falcons, this all-time series is now dead even at 54 wins apiece.

The Falcons are 7-3 ATS in their past 10 games against top 10 pass defenses.

Pittsburgh Steelers vs. Cincinnati Bengals Odds

    • Spread
      Steelers -1
    • Moneyline
      Steelers -120, Bengals +100
    • Total
      34.5

The Steelers have won seven of the past eight meetings with the Bengals in which there were fewer than 44 points scored.

Cincinnati is 6-2 ATS since the beginning of last season when opposing a bottom-10 offense.

Carolina Panthers vs. Tennessee Titans Odds

    • Spread
      Titans -3.5
    • Moneyline
      Panthers +160, Titans -190
    • Total
      37.5

Unders are 5-2 in Carolina’s last seven games against bottom 10 pass defenses.

Eight times since the beginning of last season have the Titans faced a bottom 10 offense — eight times under tickets have cashed.

Tampa Bay Buccaneers vs. Indianapolis Colts Odds

    • Spread
      Colts -2.5
    • Moneyline
      Buccaneers +115, Colts -135
    • Total
      43.5

Since the beginning of last season, the Buccaneers are just 3-8 ATS when facing a top-10 run offense.

The Colts have lost four of five home games outright this season.

New England Patriots vs. New York Giants Odds

    • Spread
      Patriots -3
    • Moneyline
      Patriots -170, Giants +145
    • Total
      33.5

Since 2021, the Patriots are 6-2-1 ATS as road favorites.

The Giants have covered five of six games against bottom 10 passing offenses since the beginning of last season.

Jacksonville Jaguars vs. Houston Texans Odds

    • Spread
      Jaguars -1
    • Moneyline
      Jaguars -120, Texans +100
    • Total
      48.5

The Jags have consecutive games in this series — they haven’t won three in a row since 2005-06 (bonus points for you if you remember that LaBrandon Toefield ran for over 100 yards for the David Garrard-led Jaguars in the final game of 2005).

Under tickets have cashed in seven of Houston’s past eight games against a bottom 10 pass offense.

MORE: NFL MVP Odds

Cleveland Browns vs. Denver Broncos Odds

    • Spread
      Broncos -2.5
    • Moneyline
      Browns +115, Broncos -135
    • Total
      35.5

Since the beginning of last season, the Browns are just 3-8 ATS following an outright win.

The Broncos are just 7-16-1 ATS when favored since the start of 2021.

Los Angeles Rams vs. Arizona Cardinals Odds

    • Spread
      Rams -0.5
    • Moneyline
      Rams -110, Cardinals -110
    • Total
      44.5

The Rams have won eight straight at Arizona, holding the Cardinals to 16.3 PPG over that stretch.

Overs are 8-4-1 when the Cardinals play at home since the beginning of last season (5-8-1 on the road).

Kansas City Chiefs vs. Las Vegas Raiders Odds

    • Spread
      Chiefs -9.5
    • Moneyline
      Chiefs -450, Raiders +360
    • Total
      44.5

The Chiefs have scored at least 30 points in seven straight against the Raiders (6-1 outright in those games).

Unders are 9-2 in Raider games this season and 6-3 in their past nine games against top 10 offenses.

Buffalo Bills vs. Philadelphia Eagles Odds

    • Spread
      Eagles -3.5
    • Moneyline
      Bills +155, Eagles -185
    • Total
      48.5

Unders are 10-2 over Buffalo’s past 12 road games.

Overs are 12-7 following an Eagles win since the beginning of last season.

Baltimore Ravens vs. Los Angeles Chargers Odds

    • Spread
      Ravens -4
    • Moneyline
      Ravens -210, Chargers +175
    • Total
      46.5

The Ravens have covered five of their past seven warm-weather games.

The Chargers have lost eight of their past 10 games outright against top 10 offenses.

Chicago Bears vs. Minnesota Vikings Odds

    • Spread
      Vikings -3.5
    • Moneyline
      Bears +150, Vikings -175
    • Total
      44.5

Overs are 14-5 since the beginning of last season following a Chicago loss (the highest such rate in the league).

The Vikings have won five straight against the Bears. A sixth straight win would match their longest win streak over the NFC North rival since 1976.

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