NFL Week 6 Picks, Predictions Against the Spread: Bears, Lions looking to upset?

What are our free NFL picks and predictions for Week 6 of the 2021 NFL season as we try to solve Vegas' increasingly sharp lines.

After one of the most exciting weeks of football in recent memory, we look ahead to try and figure out what will happen next. Let’s take a look at our Week 6 NFL betting picks and predictions against the spread.

NFL Week 6 picks and predictions

The deeper we get into the season, the sharper the lines get. Let’s see if we can figure out Vegas in Week 6.

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Sunday Week 6 free NFL picks and predictions

Here are the Week 6 picks and predictions and NFL odds for Sunday’s games as of 2 PM ET on October 16.

Miami Dolphins (-3) at Jacksonville Jaguars

Time and channel: 9:30 AM ET, CBS

The Dolphins and Jaguars face-off in London is the NFL’s second overseas game of the season. Tua Tagovailoa is expected to return, which gives the Dolphins a much-needed boost at quarterback. On the other side, Trevor Lawrence has been playing better, and I just have a funny feeling he gets his first NFL win this week.

Dolphins vs. Jaguars prediction: Jaguars 26, Dolphins 23

Kansas City Chiefs (-6.5) at Washington Football Team

Time and channel: 1 PM ET, CBS

The Chiefs are off to a poor start to the 2021 season, and Patrick Mahomes is third in the NFL in interceptions. With that being said, coming off a blowout loss at home, expect the Chiefs to fire back with a vengeance. The Football Team will score plenty of points, but the Chiefs will score a lot more.

Chiefs vs. Washington prediction: Chiefs 38, Washington 28

Los Angeles Chargers at Baltimore Ravens (-2.5)

Time and channel: 1 PM ET, CBS

The Ravens keep finding ways to win games. They’ve already won three games this season they definitely should’ve lost. The Chargers are flying just as high as the Ravens as these two offensive juggernauts collide. This one has “Game of the Week” potential. I like the Ravens to get it done at home.

Chargers vs. Ravens prediction: Ravens 31, Chargers 27

Minnesota Vikings (-1.5) at Carolina Panthers

Time and channel: 1 PM ET, FOX

Kirk Cousins has cooled off considerably following his strong first three weeks. On the other side, Sam Darnold stumbled as well, reverting back to his old ways as the Panthers dropped a home game to the Eagles. This week, the Panthers bounce back as Cousins’ downward spiral continues.

Vikings vs. Panthers prediction: Panthers 24, Vikings 20

Green Bay Packers (-5.5) at Chicago Bears

Time and channel: 1 PM ET, FOX

The Packers are winners of four straight but easily could’ve lost two of their last three games. Eventually, their luck is going to run out. Justin Fields has been a disaster, largely because Matt Nagy refuses to let him run. At some point, Fields needs to take matters into his own hands. This game just smells funny to me.

Packers vs. Bears prediction: Bears 26, Packers 24

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Cincinnati Bengals (-3.5) at Detroit Lions

Time and channel: 1 PM ET, FOX

The Lions are winless on the season. Yet, they’ve been reasonably competitive in all five of their games, and they should’ve won two of them. The Bengals are much improved from last season, but they shouldn’t really be road favorites against anyone. The Lions pick up their first win this week.

Bengals vs. Lions prediction: Lions 24, Bengals 21

Houston Texans at Indianapolis Colts (-10)

Time and channel: 1 PM ET, CBS

The Colts are coming off a crushing defeat after they seemingly had a road win in Baltimore in the bag. They are angry and are going to take out their frustrations on the Texans, who blew their chance at a second win last week as well.

Texans vs. Colts prediction: Colts 31, Texans 13

Los Angeles Rams (-9) at New York Giants

Time and channel: 1 PM ET, FOX

It never really felt like the Giants had a chance against the Cowboys last week. The good news is they should get Sterling Shepard and Darius Slayton back. I think Daniel Jones will end up clearing the concussion protocol as well. The Rams are going to win this game, but the Giants will keep it closer than you think.

Rams vs. Giants prediction: Rams 31, Giants 23

Arizona Cardinals at Cleveland Browns (-3.5)

Time and channel: 4:05 PM ET, FOX

The Cardinals are clearly a good team, but they’re not 5-0 good. The Browns went toe to toe with Justin Herbert and the Chargers. Their defense may not be able to stop Kyler Murray, but they’re going to do enough to earn a home win.

Cardinals vs. Browns prediction: Browns 30, Cardinals 24

Las Vegas Raiders at Denver Broncos (-4)

Time and channel: 4:25 PM ET, CBS

I have to imagine the Broncos laying a standard field goal at home will be one of the biggest public plays of the week. The Raiders are losers of two straight and are game-planning with an interim head coach. The Broncos seem too obvious, so I’m going the other way.

Raiders vs. Broncos prediction: Raiders 23, Broncos 20

Dallas Cowboys (-3.5) at New England Patriots

Time and channel: 4:25 PM ET, CBS

The Cowboys are a much better team than the Patriots. A 4-point spread may seem low, but this line would be 10 if the game were in Dallas. It can only be so high on the road. The Cowboys have covered in every game this season, but the jaded fan in me keeps expecting a letdown.

Cowboys vs. Patriots prediction: Cowboys 24, Patriots 21

Seattle Seahawks at Pittsburgh Steelers (-5)

Time and channel: 8:20 PM ET, NBC

The Steelers got to execute their preferred game plan last week with Ben Roethlisberger attempting a season-low 25 passes. With the Seahawks not starting Russell Wilson for the first time since 2011, these feel like teams headed in opposite directions. This week, the Steelers will remind everyone that every time they win a game, it’s a fluke.

Seahawks vs. Steelers prediction: Seahawks 20, Steelers 17

Monday Night Football: Free NFL picks and predictions

Here are the Week 6 picks and predictions and NFL odds for Monday’s game as of 2 PM ET on October 16.

Buffalo Bills (-5.5) at Tennessee Titans

Time and channel: 8:15 PM ET, ESPN

The Bills look like the best team in the NFL right now. The Titans, meanwhile, just want to run the ball 35 times a game. Josh Allen is too good to let the Titans hide Ryan Tannehill. With that being said, this feels like a prime letdown spot for the Bills after the high of a road win in Kansas City.

Bills vs. Titans prediction: Bills 27, Titans 24

Jason Katz is a Fantasy Analyst at Pro Football Network. You can follow him on Twitter: @jasonkatz13 and find more of his work here. Don’t forget to listen to the PFN Fantasy Football podcast and check out our free fantasy newsletter.