Week 5 of the 2025 NFL season kicked off with an NFC West showdown between the San Francisco 49ers and Los Angeles Rams. Despite being without Brock Purdy, George Kittle, Ricky Pearsall, Jauan Jennings, and Brandon Aiyuk, the 49ers pulled off a surprising 26-23 overtime win.
Sunday’s slate begins with an early game in London between the Cleveland Browns and Minnesota Vikings. Rookie Dillon Gabriel is set to make his first NFL start, but several key players will miss the week’s action and have been listed as inactive.
NFL Inactives for Week 5
Las Vegas Raiders at Indianapolis Colts
Brock Bowers has been dealing with a knee injury and was initially expected to play this week. However, plans changed on Saturday, as NFL insider Ian Rapoport reported that the Las Vegas Raiders’ second-year tight end is now unlikely to suit up against the Indianapolis Colts. Now, he’s officially inactive.
Heading into Week 5, Bowers is ranked as the third-best player at his position in the league based on PFSN’s Tight End Impact metric.
Raiders designated as out:
- CB Eric Stokes
- LB Germaine Pratt
- G Caleb Rogers
- TE Michael Mayer
- TE Brock Bowers
- DL Leki Fotu
Colts designated as out:
- WR Alec Pierce
- QB Riley Leonard
- CB Kenny Moore II
- RB Tyler Goodson
- LB Buddy Johnson
- T Luke Tenuta
- DT Eric Johnson II
New York Giants at New Orleans Saints
Giants designated as out:
- LB Demetrius Flannigan-Fowles
- OL Evan Neal
- DL Elijah Garcia
- QB Jameis Winston
- RB Tyrone Tracy Jr.
Saints designated as out:
- DE Chase Young
- CB Isaac Yiadom
- G Cesar Ruiz
- DT Khristian Boyd
- RB Devin Neal
- OL Xavier Truss
Dallas Cowboys at New York Jets
Cowboys designated as out:
- WR KaVontae Turpin
- RB Miles Sanders
- OL Tyler Booker
- OL Tyler Guyton
- WR CeeDee Lamb
- DT Jay Toia
- DE Marshawn Kneeland
Jets designated as out:
- DE EDGE Jermaine Johnson
- CB Michael Carter II
- RB/KR Kene Nwangwu
- OT Esa Pole
- TE Stone Smartt
- TE Jelani Woods
- DT Leonard Taylor III
Miami Dolphins at Carolina Panthers
Dolphins designated as out:
- CB Storm Duck
- QB Quinn Ewers
- DT Zeek Biggers
- RB Jaylen Wright
- WR Cedrick Wilson Jr
Panthers designated as out:
- TE Ja’Tavion Sanders
- CB Chau Smith-Wade
- RB Chuba Hubbard
- LB Claudin Cherelus
- DT Jaden Crumedy
- DT Tershawn Wharton
Houston Texans at Baltimore Ravens
Lamar Jackson suffered a hamstring injury last week during the disappointing loss to the Kansas City Chiefs. He’s been ruled out for Week 5, and there’s a strong chance the two-time NFL MVP could also miss next week. With the Ravens heading into a Week 7 bye, a return in Week 8 appears to be the most likely scenario for Jackson.
Texans designated as out:
- WR Braxton Berrios
- QB Graham Mertz
- CB Zion Childress
- OL Jarrett Kingston
- OL Trent Brown
- LB Christian Harris
Ravens designated as out:
- ILB Roquan Smith
- CB Chidobe Awuzie
- QB Lamar Jackson
- SS Kyle Hamilton
- FB Patrick Ricard
- CB Marlon Humphrey
- T Ronnie Stanley
Denver Broncos at Philadelphia Eagles
Broncos designated as out:
- QB Sam Ehlinger
- RB Jaleel McLaughlin
- DL Sai’Vion Jones
- OT Frank Crum
- OLB Que Robinson
Eagles designated as out:
- QB Sam Howell
- CB Mac McWilliams
- C Drew Kendall
- WR Xavier Gipson
Tennessee Titans at Arizona Cardinals
Titans designated as out:
- RT JC Latham
- WR Bryce Oliver
- OT John Ojukwu
- OL Blake Hance
- CB Samuel Womack
- WR James Proche
- OL Brant Banks
Cardinals designated as out:
- G Evan Brown
- OT Josh Fryar
- OT Demontrey Jacobs
- CB Max Melton
- DE Darius Robinson
- LB Xavier Thomas
- WR Xavier Weaver
Washington Commanders at Los Angeles Chargers
Commanders designated as out:
- QB Josh Johnson
- WR Terry McLaurin
- LB Ale Kaho
- LB Kain Medrano
- G Brandon Coleman
- WR Noah Brown
Chargers designated as out:
- WR Derius Davis
- S RJ Mickens
- CB Nikko Reed
- OLB Kyle Kennard
- T Joe Alt
- TE Will Dissly
- DL Naquan Jones
Tampa Bay Buccaneers at Seattle Seahawks
Buccaneers designated as out:
- WR Mike Evans
- RB Bucky Irving
- CB Jamal Dean
- CB Benjamin Morrison
- S Christian Izien
Seahawks designated as out:
- DE Jared Ivey
- G Josh Jones
- TE Nick Kallerup
- LB DeMarcus Lawrence
- S Julian Love
- WR Cody White
- CB Devon Witherspoon
Detroit Lions at Cincinnati Bengals
Lions designated as out:
- LT Taylor Decker
- LB Zach Cunningham
- CB Khalil Dorsey
- RB Sione Vaki
- OL Kingsley Equakun
- DL Chris Smith
- DL Mekhi Wingo
Bengals designated as out:
- WR – Jermaine Burton
- CB – Marco Wilson
- TE – Cam Grandy
- DT Jordan Jefferson
- DE Shemar Stewart
Buffalo Bills at New England Patriots (SNF)
Bills designated as out:
- WR Elijah Moore
- CB Brandon Codrington
- DB Jordan Hancock
- LB Dorian Williams
- OT Chase Lundt
- DT Ed Oliver
- DT TJ Sanders
Patriots designated as out:
- OLB K’Lavon Chaisson
- DT Eric Gregory
- G Caedan Wallace
- WR Efton Chism
- QB Tommy DeVito
Kansas City Chiefs at Jacksonville Jaguars (MNF)
Chiefs designated as out:
- CB Kristian Fulton
- TE Jared Wiley
- RB Elijah Mitchell
- DT Omarr Norman-Lott
- OL Hunter Nourzad
- DE Malik Herring
Jaguars designated as out:
- DE Travon Walker
- LB Yasir Abdullah
- OL Wyatt Milum
- DL Danny Striggow
- DT Khalen Saunders Sr.