An NFC West showdown with major division implications goes down at SoFi Stadium when the San Francisco 49ers battle the Los Angeles Rams. With marquee injuries on both sides of the ball — including Christian McCaffrey and Cooper Kupp — who will carry the weight of this all-important matchup?
Inactives will be updated as soon as official lists are unveiled.
San Francisco 49ers vs. Los Angeles Rams Inactives
49ers Designated as Out
- OG Ben Bartch
- LB Tatum Bethune
- QB Joshua Dobbs
- TE George Kittle
- CB Darrell Luter
- WR Deebo Samuel
Rams Designated as Out
- TE Davis Allen
- QB Stetson Bennett
- OT Geron Christian
- LB Brennan Jackson
- WR Cooper Kupp
- RB Cody Schrader
Latest Injury Report News and Updates
On the 49ers’ side, Charvarius Ward and Nick Bosa returned to practice on Friday (Sept. 20), giving the defense a boost. On offense, Brock Purdy will already be without McCaffrey and Deebo Samuel, and he’ll almost assuredly be without George Kittle as well.
On the Rams’ side, K Joshua Karty (groin), CB Cobie Durant (toe), and NT Bobby Brown III (ankle) are all questionable. They’ll be without Kupp, WR Puka Nacua, and TE Davis Allen.
MORE: Simulate the Season With PFN’s Playoff Predictor
The Rams have three starting offensive linemen on IR: C Steve Avila, G Jonah Jackson, and T Joe Noteboom. The secondary is also suffering — S John Johnson III and CBs Derion Kendrick and Tre Tomlinson have been ruled out for the season. In total, the Rams have 11 players on injured reserve.
Who Comprises the Projected Starting Lineup for Each Team?
49ers Projected Starters
The projected starting lineup is based on the current 49ers depth chart.
- Quarterback: Brock Purdy
- Running Back: Jordan Mason
- Fullback: Kyle Juszczyk
- Wide Receiver: Brandon Aiyuk, Jacob Cowing
- Tight End: George Kittle
- Left Offensive Tackle: Trent Williams
- Left Offensive Guard: Aaron Banks
- Center: Jake Brendel
- Right Offensive Guard: Spencer Burford
- Right Offensive Tackle: Colton McKivitz
- Left Defensive End: Nick Bosa
- Left Defensive Tackle: Maliek Collins
- Right Defensive Tackle: Javon Hargrave
- Right Defensive End: Leonard Floyd
- Strongside Linebacker: De’Vondre Campbell Sr.
- Middle Linebacker: Fred Warner
- Weakwide Linebacker: Curtis Robinson
- Left Cornerback: Charvarius Ward
- Right Cornerback: Deommodore Lenoir
- Free Safety: Ji’Ayir Brown
- Strong Safety: Talanoa Hufanga
- Kicker: Jake Moody
- Punter: Mitch Wishnowsky
- Long Snapper: Taybor Pepper
- Kickoff Returner: Jordan Mason
- Punt Returner: Ronnie Bell
Rams Projected Starters
The projected starting lineup is based on the current Rams depth chart.
- Quarterback: Matthew Stafford
- Running Back: Kyren Williams
- Wide Receiver: Demarcus Robinson, Tyler Johnson
- Tight End: Hunter Long
- Right Offensive Guard: Kevin Dotson
- Right Offensive Tackle: Rob Havenstein
- Defensive End: Braden Fiske
- Defensive Tackle: Kobie Turner
- Nose Tackle: Bobby Brown III
- Left Outside Linebacker: Jared Verse
- Left Inside Linebacker: Christian Rozeboom
- Right Inside Linebacker: Michael Hoecht
- Right Outside Linebacker: Byron Young
- Left Cornerback: Cobie Durant
- Right Cornerback: Tre’Davious White
- Free Safety: Russ Yeast
- Strong Safety: Kamren Curl
- Kicker: Joshua Karty
- Punter: Ethan Evans
- Long Snapper: Alex Ward
- Kickoff Returner: Blake Corum
- Punt Returner: Kyren Williams