Friday Night Football NFL DFS picks: DraftKings lineup includes Trey Lance, Breece Hall, and Trey Sermon

After compiling dozens of game scenarios for today's Friday Night Football preseason NFL games, here are our favorite DFS DraftKings lineup picks.

Last night reminded us why preseason games can be unpredictable. If you’re competing in a DraftKings DFS tournament for Friday Night Football, then you need more answers than questions. We’ve run through dozens of potential scripts — including realistic snap counts — for tonight’s games, and here is our recommended fantasy football lineup.

Top DraftKings NFL DFS picks for Friday Night Football

Tonight we’re playing a DraftKings “Classic” tournament that includes one QB, two RBs, three WRs, one TE, one Flex, and one D/ST.

DraftKings Sportsbook

States: NY, LA, AZ, CO, PA, NJ, IN, IL, IA, MI, VA, WY, TN, WV


Because this is the preseason, and because even sites like DraftKings had no idea who would play when they set pricing, they gave every player a $5,500 price tag.

Trey Lance, QB, San Francisco 49ers

We could go the “safer” route and start a competent backup like Philadelphia’s Gardner Minshew, who could see a solid half of work. But he’d also likely play with the backups and doesn’t have Trey Lance’s upside. Lance is an extraordinarily talented QB with a bright NFL future who should put to rest the (many?) doubts fantasy managers and experts still have.

Breece Hall, RB, New York Jets

How much work will Breece Hall get? That’s the challenge. This will be the first game action for the first RB taken in this year’s NFL draft. The Jets need a healthy Hall this season, and they also need to see if he’s their Year 1 bell cow or a 1A back to Michael Carter’s 1B.

Trey Sermon, RB, San Francisco 49ers

One of my favorite off-the-radar RBs this summer, Trey Sermon was a deservedly trendy fantasy draft pick last August. Now he’s persona non grata in most circles. Not here, though. Sermon arguably is the most talented RB in the Niners’ backfield. Optimally, he could begin the season in a timeshare with Elijah Mitchell. His return to relevance officially begins tonight.

Romeo Doubs, WR, Green Bay Packers

Romeo Doubs has been one of the biggest rookie names in camp. While catching balls thrown by Jordan Love and perhaps Danny Etling might cap his ceiling, Doubs is too promising to pass up in DFS.

Danny Gray, WR, San Francisco 49ers

Danny Gray typifies the high-risk, high-reward DFS play. He’s battling for the No. 4 WR job, with an outside shot at pushing for a starting role by midseason. San Francisco should give him plenty of run tonight, and the prospect of a deep connection with Lance is worth the risk.

Deon Cain, WR, Philadelphia Eagles

A 2018 sixth-round draft pick, Deon Cain missed his rookie campaign with a torn ACL. Four years and three teams later, he’s trying to make the Eagles. While the top three spots are pretty much locked up, there’s an opening for a No. 4 if Philly bails on Jalen Reagor. Cain possesses the athletic ability to seize the opportunity.

Stephen Anderson, TE, Arizona Cardinals

Not a flashy pick, Stephen Anderson has the advantage of being “likely to play.” In preseason parlance, that means he’s worth a close look.

What makes him startable? The Cardinals aren’t expected to play Zach Ertz, Trey McBride, or Maxx Williams. The 29-year-old Anderson is fighting to stay employed. With 60 career NFL receptions, he might be one of the most experienced playmakers on the field.

Chris Evans, RB, Cincinnati Bengals

Chris Evans and Samaje Perine are battling for the handcuff role behind Joe Mixon. PFN Pass subscribers already know that based on historical data, Mixon is a significant injury/regression risk this ear. Evans could be surprisingly valuable this season, and he could be surprisingly valuable tonight.

Jacksonville Jaguars, D/ST

They’re entering preseason game No. 2, while the opposing Browns are in a state of chaos in their preseason debut. We like the Jags’ odds of stepping up against a team that probably will throw a lot of backups their way, including quarterbacks Joshua Dobbs and Josh Rosen. Bring it.


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