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    Colts vs. Bills prediction, pick, odds, and how to watch the Week 11 game

    Here is our prediction for the Colts vs. Bills Sunday Night Football game, along with betting odds, and TV channel/radio station info.

    The Indianapolis Colts and Buffalo Bills are both coming off wins against bottom-dwelling AFC squads. Here’s our prediction, TV channel and listening information, and the NFL odds for the two playoff hopefuls in this Week 11 matchup.

    Indianapolis Colts vs. Buffalo Bills prediction and odds | Week 11

    • Spread: -7 Bills (Odds from DraftKings sportsbook)
    • Moneyline: -310 Bills, +245 Colts
    • Over/Under: 49

    Last week, the Colts held off their divisional rival Jacksonville Jaguars 23-17 after coming out hot in the first quarter. Running back Jonathan Taylor nearly rushed for 100 yards in the opening quarter and finished the day with 116 total yards as he carried Indianapolis back to a .500 record.

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    The Bills, who’d just lost to the Jaguars the previous week 9-6, blew out their divisional rival New York Jets 45-17 on Sunday. The loss to Jacksonville certainly lit a fire in Buffalo as they improved to 6-3 on the season.

    Can Buffalo set Indianapolis back in the playoff race?

    Both the Bills and Colts are firmly in the NFL Playoff picture heading into Week 11. The current odds for Sunday’s contest have Buffalo winning by a touchdown. In the Bills’ six wins this season, they’ve won by more than double-digits, while their three losses are by a combined 13 points.

    The Bills aren’t shy to score. The same could be said about the Colts, who’ve scored 23 or more points in all but one game this season. In four of the last five games, Indianapolis has scored 30 or more points, including 45 against the Jets (just like Buffalo did this past week).

    Colts vs. Bills prediction

    Buffalo has been a Super Bowl favorite since they fell to the Chiefs in the AFC Conference Championship game last January. They’ve shown they can win on both sides of the football but rely heavily on Josh Allen being his best self.

    Indianapolis’ success, meanwhile, relies more so on Taylor and the run game. Carson Wentz has been serviceable throughout 2021, but he hasn’t found the same success he had early on in his career. 

    One thing both teams have in common is their ability to take care of the football and create turnovers. Whoever can do that best, and control the clock, should come away victorious. The slight edge goes to Buffalo and their league-leading defense with 24 takeaways.

    Colts vs. Bills Prediction: Bills 31, Colts 23

    How to watch and listen to Colts vs. Bills this week

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