Colts vs. 49ers prediction, pick, odds, and how to watch the Week 7 game

What are the Colts vs. 49ers odds and prediction, how to watch including the channel, and how can you listen to the Week 7 contest?

The Colts vs. 49ers is a battle between two very different teams. On one side, you have the Colts, who are coming off a dominant performance against the Texans. On the other, you have the 49ers, who still have questions at the QB position and are now coming off a bye. Here’s the channel for the Week 7 contest, the current NFL odds, and a pick and prediction.

Indianapolis Colts vs. San Francisco 49ers prediction and odds | Week 7

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  • Spread: San Francisco 49ers -3.5
  • Moneyline: 49ers -210, Colts +175
  • Over/Under: 45 (Over -110, Under -110)
  • Odds from DraftKings sportsbook.

The Indianapolis Colts come into this game looking to build off their 31-3 win over the Houston Texans last week. They are still a long way from the top of the AFC South at 2-4, but a somewhat easy schedule in the coming weeks could put them back in contention.

Carson Wentz has thrown for 1,545 yards, 9 touchdowns, and an interception on 64.2% passing so far this year, and he looks more and more comfortable in the Indianapolis’ offense as the season progresses. Meanwhile, Jonathan Taylor has rushed for a team-high 472 yards and 4 touchdowns. His game against Houston was his best of the year, and he is finally falling into the RB1 role that everyone imagined for him.

The 49ers are coming off a bye but suffered a tough 17-10 loss to the Cardinals the week before. They played Arizona well, and in hindsight, a one-TD loss to the only undefeated team in the NFL is not a bad thing. The bigger problem is that they’re dealing with two banged-up QBs in Jimmy Garoppolo and Trey Lance and a mess at the RB position. It still isn’t clear who their lead back will be in this contest.

Colts vs. 49ers prediction

If you had asked me this question at the beginning of the season, I never would have thought of predicting a possible upset for the Colts on the road against San Francisco. However, here we are. Indianapolis is 7-2 ATS in their last nine road games and 4-1 ATS in their last five contests overall. Wentz is playing like the best QB in this matchup, and as great as the 49ers’ coaching staff is, they have their hands tied behind their backs due to injuries.

Colts vs. 49ers prediction: Colts 24, 49ers 21

How to watch and listen to Colts vs. 49ers this week

  • Start time: 8:20 PM ET
  • Channel: NBC
  • Live stream: 
    • Sling
    • NBC App
    • Hulu + Live TV
    • fuboTV
    • YouTube TV
    • DirecTV NFL Sunday Ticket
  • Listen:
    • Local Indianapolis: Indianapolis on 93.5 & 107.5 The Fan and 97.1 HANK FM.
    • Local San Francisco: KGO 810 AM and KSAN 107.7 FM The Bone
    • TuneIn Radio
    • Sirius XM Radio

Ryan Gosling is the Chief Written Content Officer for Pro Football Network. Follow him on Twitter @ryangoslingPFN.

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