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49ers vs. Seahawks Prediction, Pick: Who wins in Week 13?

What is our pick and prediction for Sunday's 49ers vs. Seahawks game? San Francisco tries to hang onto a playoff spot in an NFC West battle.

The San Francisco 49ers will face off against the Seattle Seahawks in an important game for the NFC playoff picture. San Francisco is trying to hold their spot, as they’re 6-5 with four teams only one game behind them. Seattle has struggled to a 3-8 record, although they played several games without star quarterback Russell Wilson. In this article, we offer the NFL odds with a pick and 49ers vs. Seahawks prediction.

San Francisco 49ers vs. Seattle Seahawks pick, prediction | Week 13

  • Spread: 49ers -3.5 (Odds provided by DraftKings Sportsbook)
  • Moneyline: 49ers -165, Seahawks +145
  • Over/Under: 45.5

Wilson recently returned from an injury, but he’s struggled to produce in three games. His injury may not be completely to blame, though, as he recorded a 2-3 record prior to going down.

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This is the first time in his career that Wilson has lost four consecutive games. It is also the first time the Seahawks have lost eight games in a season with him as their quarterback.

Although not all of the blame should be put on Wilson, he’s disappointed quite a bit, specifically since returning from injury. In his three games back, he’s managed 615 yards with 2 touchdowns and 2 interceptions. The Seahawks are averaging only 9.3 points per game in those contests.

49ers vs. Seahawks betting trends

Both of these teams have struggled against the spread (ATS) through 11 games this season. They each enter this contest with a 5-6 ATS record.

Nevertheless, the 49ers have been heating up, covering the spread in four of their last five games. The Seahawks haven’t found as much success, failing to cover in any of the three outings since Wilson’s returned.

These teams are also opposites in terms of the game total. San Francisco’s hit the over in 54.6% of their games. They’re averaging 1 point per game above the total this season.

Seattle’s a bit more definitive, posting a 1-9-1 over/under record in 2021. They’re hitting the under by an average of 8.8 points per game, which is the highest in the NFL by nearly 3 points.

49ers vs. Seahawks prediction

One of the key factors to this game is that it is a divisional matchup — these teams know each other well. Both defenses have been performing well recently, as they rank in the top 10 in points allowed per play over their last three contests.

The big difference between these teams is their offenses. Over the last three games, San Francisco ranks fourth in the NFL in points per play (.482). Seattle is the third-worst (.183) over the same span.

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I expect Wilson to continue to get better as his health progresses, but everything points to him taking a step back overall this season. I favor the defenses over the offenses in this matchup, and I prefer the under instead of backing a road favorite in a divisional battle.

Still, the Seahawks haven’t shown any signs of life in recent weeks, giving the team playing for a playoff spot the edge this weekend.

49ers vs. Seahawks Prediction: 49ers 20, Seahawks 13

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